1 / 40

Rare diseases in everyday practice « Google anaesthesia » ?

Rare diseases in everyday practice « Google anaesthesia » ?. F Veyckemans Clin univ. St Luc Brussels, Belgium. Outline. definition & queries sources of information pitfalls to prepare anaesthesia conclusion. Conflict of interest. Responsible for the website

obert
Download Presentation

Rare diseases in everyday practice « Google anaesthesia » ?

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Rare diseases in everyday practice« Google anaesthesia » ? F Veyckemans Clin univ. St Luc Brussels, Belgium

  2. Outline • definition & queries • sources of information • pitfalls • to prepare anaesthesia • conclusion

  3. Conflict of interest Responsible for the website tyniurl.com/m-rares Syndromes & Maladies rares en pédiatrie: anesthésie with Prof J-L Scholtes (Brussels)

  4. Outline definition & queries sources of information pitfalls to prepare anaesthesia conclusion

  5. What is a rare disease? < 1/2000 in the general population but depends on country population clustering clinical recruitment e.g., Duchenne microdeletion ch 22

  6. The anaesthesiologist’s perspective care for a « rare disease » patient during a brief but often critical period of time 2) consider a disease is rare at the first time we meet it !

  7. The anaesthetist’s queries 1) what is it ? malformative syndrome metabolic disease muscle disease 2) any increased anaesthetic risk ? 3) any special issue(s) regarding perianaesthetic care ?

  8. Outline • definition & queries • sources of information • pitfalls • to prepare anaesthesia • conclusion

  9. Sources of information (1) On the disease : Books • Inborn metabolic diseases, 5thed, Saudubray & coll (Springer, 2012). • Smith’s recognizable patterns of human malformations 6thed, KL Jones (Elsevier Saunders, 2006) • Atlas of Metabolic Diseases 2nded WL Nyhan & coll (Hodder Arnold, 2005)

  10. Sources of information (1) On the disease : Internet * Google * Orphanet name : expert summary + peer reviewed *OMIM: omim.orgonline Mendelian inheritance * GARD: Genetic & Rare Diseases information center * NORD * pubmed * disease-related website: parents’ groups

  11. Sources of information (2) Anaesthetic management of the disease Books • Anesthesia for genetic, metabolic & dysmorphic syndromes of childhood Baum & O’Flaherty (Lippincott, Williams & Wilkins, 2007) • Genetic syndromes : recognition and perioperative aspects. B Bissonnette, B Dalens .. (McGraw-Hill, 2006) • most Textbooks on Paediatric Anaesthesia contain a chapter on the most common rare diseases or syndromes

  12. Sources of information (2) Anaesthetic management of the disease Internet: « disease and anaesthesia » *Pubmed *Google * Orphanet name  emergency care * VIRTANES  maladies rares de l’enfant Or discussion lists : PAC

  13. Outline • definition & queries • sources of information • pitfalls • to prepare anaesthesia • conclusion

  14. Different names for the same disease Treacher-Collins = Franceschetti-Klein = mandibulofacial dysostosis

  15. Different diseases with similar name e.g., Hecht-Beals syndrome = congenital arachnodactyly with contractures CCA syndrome  marfanoid syndrome Hecht syndrome = Dutch-Kentucky syndrome = trimus pseudocamptodactyly syndrome = distal arthrogryposis type 7  difficult airway

  16. Genetics are complex

  17. Genetics are complex one gene  one protein  one function  one phenotype

  18. Genetics are complex one gene other controller/inhibitor genes  inactivation of chromosome one protein RNAm  one function  environmental factors one phenotype

  19. Genetics are complex • one phenotype can result from different mutations/genes • mutation(s) of one gene  different phenotypes • variable penetrance of some mutations • many mutations are sporadic  no familial history • results often not available in time

  20. Validity of the information ? * Google ranking of links according to a complex algoritm not to quality of data check : source of data ? Wikipedia date of last update

  21. Validity of the information? • Case reports - often isolated cases - relative scientific value • no problem : luck ? • complication : cause-effect vs association ? poor management ? • date : old drugs ? +description of the disease from the anaesthetist’s point of view (date ?)

  22. Validity of the information ? Ideal: case series « data from case series for a rare condition may be the best evidence a clinician can rely on » The Oxford Levels of Evidence 2, 2013 Oxford Centre for Evidence-Based Medicine

  23. Validity of the information ? Medical progress often results in • prolonged survival • modification of evolution (gene therapy, transplantation)

  24. Validity of the information ! • child’s parents • child’s paediatrician: personal contact !  specific information on this child

  25. Outline definition & queries sources of information pitfalls to prepare anaesthesia conclusion

  26. My way To summarize informations evaluate anaesthetic risk plan anaesthesia

  27. NARCO acronym Neuromuscular Airway Respiratory Cardiovascular Others Malviya S, Voepel-Lewis T, Chiravuri SD et al. Does an objective system-based approach improve assessment of perioperative risk in children? A preliminary evaluation of the NARCO. Br J Anaesth 2011; 106: 352-6

  28. Basic questions Neuromuscular: developmental delay ? seizures : controlled or not ? spasticity, contractures, hypotonia ? medical treatment ? Airway : difficult intubation/ventilation ? risk for regurgitation/inhalation ? obstructive sleep apnoea ? Respiratory : reactive airway ? restrictive or obstructive syndrome ? chronic lung infection ?

  29. Basic questions Cardiovascular : congenital heart disease ? dysrythmias ? cardiomyopathy ? Others : special diet ? tolerates fasting ? previous anaesthesia ? psychological issues ?

  30. Example : Willi-Prader syndrome - 1/10,000 - deletion of 15q11-q13 of paternal origin - mental retardation - morbid obesity - behaviour problems - hypogenitalism - epilepsy - rumination, mericism

  31. Example : Willi-Prader syndrome Nmental retardation, epilepsy, behavioural problems hyperphagia Asmall mouth, micrognathia Rcentral & obstructive sleep apnoea, gastrooesophageal reflux, scoliosis decreased response to hypoxaemia/hypercarbia C systemic hypertension, cor pulmonale Oobese, short stature  pain threshold central adrenal insufficiency during stress (60 %) spontaneous annual death rate: 3%

  32. Example : Willi-Prader syndrome Nmental retardation, epilepsy, behavioural problems hyperphagia Asmall mouth, micrognathia Rcentral & obstructive sleep apnoea, gastrooesophageal reflux, scoliosis decreased response to hypoxaemia/hypercarbia C systemic hypertension, cor pulmonale Oobese, short stature  pain threshold central adrenal insufficiency during stress (60 %) annual death rate: 3% treatment Short fasting Mask fit, intubation Night oximetry recovery Cardiac echo Difficult veins IV hydrocortisone Postop monitoring

  33. This patient is also a child ! Do not overlook the basics : • personal history • allergies ? • haemostasis ? • upper airway: infection ? difficult airway? • passive smoking ? • easy veins ? • BP, auscultation

  34. Outline • definition & queries • sources of information • pitfalls • to prepare anaesthesia • conclusion

  35. Conclusion (1) • check the name • seek information : disease / anaesthesia - textbooks - internet : time of update ? • Orphanet  Orphanaesthesia ? • standard but focused preop examination • summarize with NARCO

  36. Conclusion (2) • a few keys to help manage a child with a rare disease • increase interest in rare diseases • suggestion: creation of a national/APA registry of anaesthetics for patients with a rare disease  source of information

  37. APRICOT AnaesthesiaPractice In ChildrenObservationalTrial European prospective multicenterobservationalstudy: Epidemiology of severecriticalevents JOIN THE NETWORK research@esahq.org esa.apricot@gmail.com

More Related