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Indy Bekerie Annabelle Chu Leeanna Hyacinth Min Ye Shen Kiet Vo BME Senior Design 2011-2012 Preliminary Findings and Business Plan. Modular Incubation System. Delivering infants a better start. |. P: 212.854.6196 F: 212.854.8725 351 Engineering Terrace 1210 Amsterdam Ave

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slide1

Indy Bekerie

Annabelle Chu

Leeanna Hyacinth

Min Ye Shen

Kiet Vo

BME Senior Design 2011-2012

Preliminary Findings and Business Plan

Modular Incubation System

Delivering infants a better start

|

P: 212.854.6196 F: 212.854.8725

351 Engineering Terrace

1210 Amsterdam Ave

New York, NY 10027

IncuVive.weebly.com

slide2
Executive Summary
  • Company Overview
    • Develop technology to combat infant hypothermia that is viable for low-resource countries
    • Advisors are leaders in the field of Biomedical Engineering and renown neonatologists with firsthand experience in the field
  • Market
    • NGOs, non-profits, and the hospitals of over 100 developing countries
  • Business Model
    • Capital equipment model
  • Design and Development
    • Overall Plan
    • Innovative Designs
    • Proof of Concept 1.0
      • Heating sources
      • Temperature sensors
  • IncuVive Financial Projections and Key Performance Indicators

|

P: 212.854.6196 F: 212.854.8725

351 Engineering Terrace

1210 Amsterdam Ave

New York, NY 10027

Incuvive.weebly.com

slide3
Company Overview
  • Our Technology
    • Will produce the correct amount of heat, maintain temperature
    • Can be coupled with a crib and cover
    • Incorporates accurate temperature sensors
    • Utilizes an innovative feedback mechanism and alarm system
  • Advantages Over Present Solutions
    • Feedback Mechanism
    • Affordable, reliable
    • Viable for low-resource countries
  • Advantages Over Other Companies
    • Few other companies targeting developing countries

+

=

An innovative solution to combat infant hypothermia

slide4
The Market

~ 4 million annual infant mortality [3]

      • 18%-42% caused by hypothermia
        • 720,000 to 1.68 million of neonate deaths can be prevented annually
  • ~ 144 developing countries [1]

In Uganda

      • 80 per 1,000 live births [5]
      • 15 to 18 neonates suffering from hypothermia can be saved

Market Strategies

Consumers

  • National and Regional Hospitals
  • Sub-district hospitals
  • Other rural healthcare facilities
  • Uganda
  • Other developing countries

Target

Customers

  • Ministry of Health
  • NGOs
  • Donors

Neonates

|

P: 212.854.6196 F: 212.854.8725

351 Engineering Terrace

1210 Amsterdam Ave

New York, NY 10027

[3] UNICEF. Progress for children: a world fit for children statistical review. New York, NY: United Nations Children`s Fund; 2007

[5] Infant mortality rate, Uganda. Google.com/publicdata

Incuvive.weebly.com

slide5
The Market

Our MIS Will

  • Incorporate a reliable feedback mechanism
  • Revive current nonfunctional incubators
  • Convert available cribs to modest incubators

Competition

Van Hemel Baby Incubator (~ $450)

Medicine Mondiale’sLiferaft Incubator (~ $1,500)

General Electric (GE) incubators ($15,000-$40,000)

Risks and Obstacles

Secure funding for production

Partnership with the Ministry of Health and the NGO’s

Protection of Intellectual Property

Larger medical device companies

|

P: 212.854.6196 F: 212.854.8725

351 Engineering Terrace

1210 Amsterdam Ave

New York, NY 10027

slide6

Business Model

  • IncuVive in Uganda
  • We plan to follow a capital equipment model.
  • The National Medical Store will be our main purchaser of our MIS; however, we also plan to sell to NGO and private hospitals.
  • Each unit will be priced at $50 after subsidizations
  • Strategic Partnerships
  • Partnerships with NGOs such as UNICEF, ECHO, and the Gates Foundation will help offset production costs and help sustain a low margin operation.
  • We will utilize partner distribution channels in order to quickly establish operations in new markets.
slide7

Business Model

  • Expansion and Distribution
  • Our main source of income will come from market expansion.
  • Our device will be assembled locally and transported by a third party.
  • After setting up distribution in Uganda we plan to immediately expand into surrounding countries.

www.infoplease.com/atlas/country/uganda.html

slide9

Design Ideas

Heating Mat + PCM

  • Feedback System
  • Monitor and display temperature of either mat or environmental temperature
  • Monitor and display temperature of infant
  • Automatically adjust heat setting to maintain infant’s temperature in the normal range
  • Alarm if abnormal temperature readings (too high or too low)
  • Automatic shut off if temperature is too high to prevent overheating
slide10

Design Ideas

Space Heater

  • Feedback System
  • Monitor and display temperature of either mat or environmental temperature
  • Monitor and display temperature of infant
  • Automatically adjust heat setting to maintain infant’s temperature in the normal range
  • Alarm if abnormal temperature readings (too high or too low)
  • Automatic shut off if temperature is too high to prevent overheating
slide11

Design Ideas

Warm Water Pump

  • Feedback System
  • Monitor and display temperature of either mat or environmental temperature
  • Monitor and display temperature of infant
  • Automatically adjust heat setting to maintain infant’s temperature in the normal range
  • Alarm if abnormal temperature readings (too high or too low)
  • Automatic shut off if temperature is too high to prevent overheating
slide12

Decision Matrix

Methods of Heating

slide13

Use phase change material (PCM) between the neonate and the heating unit to prevent burns

  • Maintain the baby at a temperature of about 37 °C while heating unit is off
    • Methods
  • A bag of saline with a thermometer inserted was heated to 37 °C in a water bath. The saline was placed on an inactive mat and allowed to cool down.
  • The temperature of the saline was recorded every minute with a calibrated thermistor inserted into the saline until the temperature dropped to 34 °C

PoC- Saline Bag Control

slide14

Results

  • Methods
  • The PCM was activated in a microwave, then placed on the inactive mat with thermistors placed at specific locations.
  • Meanwhile a bag of saline was heated to 35 °C in a water bath and placed on the PCM.
  • The experiment was repeated with thermistors.

PoC- Phase Change Material (PCM)

slide15

Saline on PCM

Conclusion

Saline on PCM with Heating Mat

  • The PCM cannot raise the saline’s temperature to 37 °C
  • The PCM can only maintain the saline’s temperature above 35 °C for about one hour with no external heat supply
  • Other insulating materials
slide16

Most viable for

  • Water: LM34
  • Skin: Digital*
  • Ambient: NTC

Temperature Sensors

Red spirit

slide17

Long Range Plan

Apply for funding and grants and

start manufacturing

Develop extensive rapport with NGOs, WHO, UNICEF

Design and build 1st and 2nd prototype

Continue development of new products

Continue R&D

Build final prototype

Initiate first assembly

station in Uganda

Product Selection

Proof of Concept testing

slide20

Estimated Usage of Our Modular Incubation System

Estimated MIS Usage projection based on a conservative 10% outreach to all neonatal deaths from hypothermia. A more in-depth explanation is in DS2: Basic summary of problem. As you can see, the curve is sigmoidal and saturated at roughly 72,000 neonates per year.

Estimated MIS Usage projection based on a conservative 10% outreach to all neonatal deaths from hypothermia. A more in-depth explanation is in DS2: Basic summary of problem. As you can see, the curve is sigmoidal and saturated at roughly 72,000 neonates per year.

slide21

Future Plans

  • Further testing of the ability of the space heater and warm water pump to raise and maintain the temperature of a saline bag.
  • Investigate and compare the functionality of other insulating materials.
  • Begin fabrication of feedback mechanism
  • Explore alarm system
  • Finalize what products we will implement
  • in our Modular Incubation System
    • Method of Heating
    • Temperature Sensors
    • Insulating Material (if necessary)
slide22
Acknowledgments
  • Instructors
    • Dr. Elizabeth Hillman, Ph.D. , Biomedical Engineering Dept., Columbia University
    • Dr. Aaron Kyle, Ph.D. , Biomedical Engineering Dept., Columbia University
    • Mr. Keith Yeager
    • Sarah De Leo (TA)
  • Advisers and Consultants
    • Dr. Lance Kam, Ph.D., Biomedical Engineering Dept., Columbia University
    • Dr. Margaret Nakakeeto-Kijjambu, MD, Mulago Hospital
    • Dr. Richard Polin, MD, CUMC Pediatrics
    • Dr. Rakesh Sahni, MD, CUMC Pediatrics
    • Dr. Helen Towers, MD, CUMC Pediatrics
    • Dr. Yvonne Vaucher, MD, UCSD
    • Dr. David Vallancourt, Ph.D., Electrical Engineering Dept., Columbia University

IncuVive.weebly.com

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