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第二章 蛋白质与非蛋白含氮 化合物的代谢紊乱 PowerPoint PPT Presentation


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第二章 蛋白质与非蛋白含氮 化合物的代谢紊乱. 临床生物化学教研室 罗洁讲师. 主要内容. 一、体液蛋白质及其代谢紊乱. 二、氨基酸代谢紊乱. 三、嘌呤核苷酸代谢紊乱. 四、蛋白质和氨基酸检测. 第一节 体液蛋白质及其代谢紊乱. 一、血浆蛋白质的功能和分类. 二、血清蛋白质电泳组分的临床分析. 三、血浆蛋白质及其异常. 四、其他体液蛋白质. 一、血浆蛋白质的功能和分类. ( 一)血浆蛋白质的功能. 营养作用 维持血浆胶体渗透压 作为运载蛋白 组成血液 pH 缓冲系统 抑制组织蛋白酶 在血浆中起催化作用的酶

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第二章 蛋白质与非蛋白含氮 化合物的代谢紊乱

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5795121


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(

pH

Ig


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1.

1

2

12

2

30


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2.

  • 1

    • CMVLDLLDLHDL


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2

3

13

4

5

1-1-2-6


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6

LCAT

7


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1.APP

1-1-C4C3 C-APP

APR

25%APP25%APP .


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  • APR

  • APP

  • APPHb

  • APPAPP


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  • APR

  • C-

  • 121-

  • 1-C4

  • C3

  • 25APP


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APP


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2.


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5768

11.05.7

24.911.2

713

9.818.2


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(-) (-)


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  • 1

  • C-


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M

M: M


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M

IgG52 IgA21IgM12IgD2IgE0.01

111

0.5

M

MIgAIgGr

M


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IgG IgA


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1. 2.

3.1- 4.1-

5. 6.2-

7. 8.

9.C-


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(PA

RBP

TTR


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1.

  • RBP

  • TTRT4T41075

  • RBPTTR1:1RBPRBP


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2.

  • PA


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200

ALB5768

60ALB


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1.

  • 1114.7g

  • 300

  • 1519

  • 80


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2.

  • 1

  • 2

  • 3

  • 4


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3.

  • ALB

    1

    2

    3

    4

    5


1 1 at aat

1-(1-ATAAT)


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1.

90AAT

AAT

75MZSPiMM95%

PiMMPiMSPiMZPiSSPiSZPiZZ

100%8060603515


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2.

1AATZZSSMS

AAT

2AATZZZZ

ZZ1020

ZZ

3AAT


1 1 ag aag 1

1- (1-AGAAG)1.

AAGAAG


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2.

134

2

3AAG


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22

1211F

1s


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1.

HpHpHbHpHbHbHpHp


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2.

1 HpHpHp

2HpHp

3Hp Hp


2 2 m amg

2 (2-M AMG)

1.

D


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2.

2-MG

2-MG


2 6 8 95 cp 5 cp

26895%Cp5%Cp


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1.

Fe2+Fe3+Fe3+


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2.

1Wilson

Cp

CpCp80%Cp100mg/L20%Cp 300mg/L

2APP


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Fe2+Fe3+TRF TRFTRF-Fe3+TRFTRF-Fe3+TRF-Fe3+Fe3+Hb

1.


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2.

1

TRFTRF

30% 38%

TRFTRF50%90%


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2

3


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TRFTIBCTIBCTRFTRFTRFmg/L=TIBC(g/L)0.70/TIBC TRFTRF1620TRF TRFTIBCTIBC(g/L) = TRFmg/L1.43

TIBC


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C-

C-

CRP


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1.

  • CRP

  • CRP


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2.

CRPCRP2000

CRP


A saa

ASAA)

  • 12KD104

    1.


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2.

SAA2000SAA


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20150mg, ALB3010mg Tamm-Horsfall21

ALBIgGIgMAMG

2-1- RBP

Ig


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0.150.45g/L

ALBTRFTTRIgG


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1

2

3

4


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CSF

PA

ALB

IgG


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70


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I


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PKU


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I

-


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-CH2


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-


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  • 1.

    AAA)(BCAA).

    BCAA/ AAA3.0~3.521

    2.


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NH3CO2H2O


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1.

80%


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1-HGPRT

2PRPP

3-6-G6pase-6-PRPP

4APRT28-


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2.

20%

3.


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gout

  • 1020


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pH7.40.42mmol/L>0.42mmol/L

>0.48mmol/L

12

pH


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pH

IgG


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1

16

2


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188316


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1.

[H+]

[H+]

-6.25=


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  • -CONH-Cu2+2-CONH-Cu2+


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Lowry-100

0.2%2%3%-SH


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  • 280nm

  • 280nm

  • 260nm280nmg/L1.45A2800.74A260nm


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-NH3+


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  • /


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Bcg bcp

BCG BCP

  • BCGBCPBCG BCP

  • BCGBCG1030

  • BCP


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CAM SDS-PAGE


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SPECAMpH8.6pIpH


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1.

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  • ALB12122


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C.

A.

B.

F.

D.

E.


2 sds

2.SDS

SDS-AGESDS-PAGE


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SDS-PAGE


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  • PAALB12612

  • IgG

  • IgGIgGIgG


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  • 11615IgGIgAIgM


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RID RIAEIA


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14

ALBPAAATAAGHAPAMGCER

TRFCRPIgGIgMIgAC3C4

AFP

2


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  • DNA

  • Guthrie


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Thank you!


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