BIOCHEMISTRY
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BIOCHEMISTRY 生物化学. 2011.08.30. PLEASE TURN OFF OR SILENCE YOUR PHONE. Lecturers: Wang, Fei ( 王菲 ) Ph.D College of Biotechonology Institute of Sericulture & Systems Biology Li, Guanrong ( 李关荣 ) Ph.D College of Agronomy and Biotechnology Office Hours: Tuesday, 4:00-5:30PM

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BIOCHEMISTRY 生物化学

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Biochemistry

BIOCHEMISTRY

2011.08.30

PLEASE TURN OFF OR SILENCE YOUR PHONE


Biochemistry

Lecturers: Wang, Fei () Ph.D

College of Biotechonology

Institute of Sericulture & Systems Biology

Li, Guanrong () Ph.D

College of Agronomy and Biotechnology

Office Hours: Tuesday, 4:00-5:30PM

Facultys Office (1)

Email: [email protected]

[email protected]


Biochemistry

Textbooks & References

  • (

  • Lehninger Principles of BiochemistryFourth Edition

    David L. Nelson Michael M. Cox

    W.H. Freeman and Company


Biochemistry

Grading Method

  • : 20% (-7/; 3= 0)

  • : 15%X2

    1

    20-25

    2

    ,(6~8/)

  • : 50%


Biochemistry

What is Biochemistry?

Biochemistry describes in molecular terms the structures,mechanisms, and chemical processes shared byall organisms and provides organizing principles thatunderlie life in all its diverse forms, principles we referto collectively as the molecular logic of life.

()


Major aspects

Major aspects

  • various types of biomolecules

  • biochemical reactions, enzymes

  • bioenergetics

  • Metabolism, biodegradation & biosynthesis of biomolecules

  • information pathway and regulation


Why we study biochemistry

Why We Study Biochemistry

  • Because it is the mandatory course, we need its credits for graduation

  • Because it is the foundation of other bio-courses (cell biology, molecular biology, genetics, immunology, etc), we need to have a solid background for further studies

  • Because it is required in most graduate school entrance exams (bio-related majors), we need a high score

  • Because it is the routine questions on job interviews (bio-related), we need to answer them correctly and smartly


Why we study biochemistry1

Why We Study Biochemistry

  • Why blood type A cant be transfused into the person with type B?

  • Why our muscle feels sore after an exhausting sport game?

  • Why penicillin only kills bacteria not hosts?

  • Why some silkworm larvae are transparent?

  • How silk protein changes from liquid state to solid state?

  • What other applications does silkworm have?

Because it is all about life!


How to study biochemistry

How to study Biochemistry

  • Prepare yourself with the upcoming classes

  • Come to the class and take notes

  • Understand the classical experiments and thoughts that led to the foundation of principles

  • Keep in mind certain formula, structures, conventions and reactions

  • Be aware with the degree of speculativeness on certain models

  • Find out the aspects that need further studies (your interest)


Biochemistry

Biomolecules Are Constructed by a Variety of carbon bonding


Biochemistry

Biomolecules Are Compounds of Carbon with a Variety of Functional Groups


Biochemistry

(A)


Biochemistry

Macromolecules Are Polymers of block-building molecules

Proteins: polymers of amino acids

Poly-saccharides: polymers of sugars

Lipids: composed by fatty acids, glycerol, choline,.

Nucleic acids: polymers of nucleotides


Organization of biomolecules

Organization of Biomolecules


Biochemistry

http://multimedia.mcb.harvard.edu/

http://cyberbridge.mcb.harvard.edu/

http://www.openculture.com/biology_free_courses


Biochemistry

Configuration and Conformation

Configuration: the fixed spatial arrangement of atoms

Stereoisomers: molecules with the same chemical bonds but different stereochemistry-different configuration


Biochemistry

Geometric isomerism/cis-trans isomerism:/

()

()


Biochemistry

Optical isomerism:

Chiral center : A carbon atom with four different substituents asymmetric arranged 4


Biochemistry

A molecule with only one chiral carbon can have two stereoisomers; when two or more (n) chiral carbons are present, there can be 2nstereoisomers.

n2n


Biochemistry

atl=[a]tlcl

c: l:

[a]tl


Mirror image

mirror image


Biochemistry

Enantiomers (): stereoisomers are mirror images of each other

Diastereomers (): pairs ofstereoisomers that are not mirror images of each other


Biochemistry

  • DL


Biochemistry

  • RS

  • 4

  • RrightSleft


Racemate d l stereo specificity

racemateDLstereo-specificity


Biochemistry

Conformation: the spatial arrangement of substituent groups that, without breaking any bonds, are free to assume different positions in space because of the freedom of rotation about single bonds


Biochemistry


Biochemistry

  • Electrostatic interaction ()

  • Hydrogen bond ()

  • van der Waals force ()


Biochemistry

  • Hydrophobic interaction ()

23kJ/mol

470kJ/mol


Biochemistry


Biochemistry

Water forms hydrogen bonds with polar solutes


Biochemistry

  • hydrophilic)


Biochemistry

  • hydrophobic)

Hydrophobic interaction:

The forces that hold the nonpolar regions of the molecules together


Biochemistry

  • amphipathic


Biochemistry

Molecular Weight, Molecular Mass, and Their Correct Units

Mr: molecular weight (relative molecular mass)

is defined as the ratio of the mass of a molecule of that substance to one-twelfth the mass of carbon-12 (12C)

12C1/12

Molecular mass (m):mass of one molecule, or the mo-

lar mass divided by Avogadros number

daltondDa

1 d= 12C1/12 1.6602x10-27kg

1nm=10=10-3mm=10-6mm=10-9m

1pg=10-3ng=10-6mg=10-9mg=10-12g


Chemical evolution of biomolecules

Chemical Evolution of Biomolecules


Biochemistry

  • 20

  • 5

  • 2

  • 1

  • 1

  • 1


Wish we all have a good journey in biochemistry

Wish we all have a good journey in Biochemistry


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