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Synaptic Plasticity II

Synaptic Plasticity II. 30 March 2012. Things you can watch. http://www.youtube.com/watch?v=JB7jSFeVz1U http://symphonyofscience.com/ http://www.youtube.com/watch?v=UyyjU8fzEYU. Things you can go to. TODAY: Dr . Amy Kochiek 3:15-4:15 OWS275

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Synaptic Plasticity II

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  1. Synaptic Plasticity II 30 March 2012

  2. Things you can watch • http://www.youtube.com/watch?v=JB7jSFeVz1U • http://symphonyofscience.com/ • http://www.youtube.com/watch?v=UyyjU8fzEYU

  3. Things you can go to TODAY: Dr. Amy Kochiek 3:15-4:15 OWS275 Agriculture and Climate Change: Can Agriculture Help? Monday April 2: Dr. Kerri Carlson 3:15-4:15 OWS275 Fishing for Answers: Using the Zebrafish as a Model for Understanding Human Development and Disease" Wednesday April 4: Dr. Dana Hubert-Lima 3:45-4:45 OWS257 Chromatin Regulation of Gene Expression: Examples from the Yeast Environmental Stress Response Thursday April 5: Dr. Jeanette McGuire 12:00-1:00 OWS275 Mating systems and Male Reproductive Success in Freshwater Turtles

  4. AMPA vs NMDA Current Whole current APV Blocks NMDA receptors

  5. NMDA and Long-Term Potentiation Tetanic stimulation epochs

  6. Is LTP NMDA-dependent? • How would you find out? Christie LA et al., PNAS (2010) 107:9412-9417

  7. Is LTP Ca2+-dependent? Mutant Wild-Type Lamsaet al. (2007) J Physiol.584: 885–894

  8. Why Tetanic Stimulation?

  9. Which of these gets your vote? • Presynaptic increase in NT release • Postsynaptic increase in NT receptor • A combination of 1 and 2 • Something else

  10. Dynamic Regulation of Synapses • Strong EPSP • AMPA + NMDA activation • Ca2+ influx • Intracellular signaling • CaMKII • PKC • AMPA receptors inserted in the postsynaptic membrane • Why is LTP thought to be important for learning and memory? 3 1 2 5 4

  11. Synaptic Regulation: Silent Synapses

  12. Synaptic Regulation: Silent Synapses

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