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Reproductive Issues Lynn M. Westphal, MD Associate Professor Director, Women’s Health Obstetrics and Gynecology Stanford University School of Medicine Cycle length Menarche: 12.8 years (9.1-17.7) Anovulatory cycles for 12-18 mo.(25% anovulatory up to 4 yrs after menarche)

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Reproductive issues l.jpg

Reproductive Issues

Lynn M. Westphal, MDAssociate Professor

Director, Women’s Health

Obstetrics and Gynecology

Stanford University School of Medicine


Cycle length l.jpg
Cycle length

  • Menarche: 12.8 years (9.1-17.7)

  • Anovulatory cycles for 12-18 mo.(25% anovulatory up to 4 yrs after menarche)

  • 5-7 years of increasing regularity

  • 28 d cycles most common (12% of women)

  • 24-35d is a normal range (0.5% have <21d and 1% have >35d)

  • Cycles lengthen again in the 40’s

  • Studies differ on cycle irregularity in relation to menopause: 2-4 years or 6-8 years prior

  • Menopause: 50.7 years


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Follicular Numbers

  • Max at 20 weeks of pregnancy: 6-7 million

  • 2 million at birth

  • 300,000 at puberty

  • 400 follicles will ovulate during a lifetime

  • 1000 oocytes undergo atresia each month regardless of stimulation

  • Rapid decline when reach 25,000 oocytes (37-38 years old)








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