PICO Question. Would early education, by nurses on MRSA prevention and transmission reduce the number of patients under 18 years of age from contracting Community Acquired MRSA?. Define MRSA. MRSA stands for methicillin-resistant Staphylococcus aureus. It is a strain of Staph aureus distinguished from most otherbacteria by its resistance to beta-lactam, which include methicillin and other more common antibiotics such as oxacillin,penicillin and amoxicillin..