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2004-2005 Chemotherapeutics Review

2004-2005 Chemotherapeutics Review. 10 March 2014 12:05 PM. Abacavir. Antiretroviral Nucleoside reverse transcriptase inhibitor (NRTI). Acyclovir. Antiherpes Purine analog Phosphorylated to inhibitor of viral DNA polymerase. Albendazole. Antihelminthic Treatment of intestinal roundworms.

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2004-2005 Chemotherapeutics Review

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  1. 2004-2005Chemotherapeutics Review 10 March 201412:05 PM

  2. Abacavir • Antiretroviral • Nucleoside reverse transcriptase inhibitor (NRTI)

  3. Acyclovir • Antiherpes • Purine analogPhosphorylated to inhibitor of viral DNA polymerase

  4. Albendazole • Antihelminthic • Treatment of intestinal roundworms

  5. Alemtuzumab • Antineoplastic • Anti-CD52 antibody

  6. Amantadine • AntiviralAntiparkinson • Treatment of Influenza A Inhibits replicationat the stage of uncoating

  7. Amikacin • Aminoglycoside antibioticBactericidal protein synthesis inhibitor • 30S ribosomeFreezes initiation

  8. Aminoglutethimide • AntineoplasticImmunosuppressive • Glucocorticoid antagonistAromatase inhibitor(decreases steroid synthesis)

  9. Aminoglycosides • AntibioticsBactericidal protein synthesis inhibitors • 30S ribosomeFreeze initiation

  10. Ampicillin • Penicillin antibioticCell wall synthesis inhibitor • Amino penicillinInhibits peptidoglycan cross-linking

  11. Amphotericin B • AntifungalPolyene antibiotic • Binds to ergosterol and alters permeabilitySystemic

  12. Amsacrine • Antineoplastic • Miscellaneous

  13. Anastrozole • AntineoplasticAntiestrogen • Aromatase inhibitor

  14. Anti-thymocyte globulin • Immunosuppressive • Anti-T cell antibody

  15. Arsenicals Melarsoprol • Tropical antiparasitic • Treatment of African Trypanosomiasis in CNS

  16. L-asparaginase • Antineoplastic • Protein synthesis inhibitor

  17. Atovaquone • Antimalarial • Depolarizes parasitic mitochondria and inhibits electron transport

  18. Azathioprine • ImmunosuppressiveAntineoplastic • Antimetabolite(“pseudofeedback inhibition” of HGPRT and PRP)

  19. Azithromycin • Macrolide antibioticBacteriostatic protein synthesis inhibitor • 50S ribosome Inhibits translocation

  20. Aztreonam • New b lactam antibiotic • Monobactam

  21. Bacitracin • AntibioticCell wall synthesis inhibitor • Topical, not a b lactam, Inhibits dephosphorylation of bactoprenol

  22. Basiliximab • Immunosuppressive • Anti-CD25 (interleukin 2 receptor) Organ transplant (antirejection)

  23. Benzathine penicillin G • Penicillin antibioticCell wall synthesis inhibitor • Inhibits peptidoglycan cross-linking Repository preparation

  24. Bleomycin • Antineoplastic • Natural productAntibiotic

  25. Busulfan • Antineoplastic • Alkylating Agent

  26. Carbenicillin • Penicillin antibioticCell wall synthesis inhibitor • Anti-pseudomonal penicillinInhibits peptidoglycan cross-linking

  27. Carmustine (BCNU) • Antineoplastic • Alkylating Agent

  28. Cefaclor • Cephalosporin antibioticCell wall synthesis inhibitor • 2nd generationOral

  29. Cefadroxil • Cephalosporin antibioticCell wall synthesis inhibitor • 1st generationOral

  30. Cefepime • Cephalosporin antibioticCell wall synthesis inhibitor • 4th generationCSF penetration

  31. Cefotaxime • Cephalosporin antibioticCell wall synthesis inhibitor • 3rd generationCSF penetration

  32. Cefoxitin • Cephalosporin antibioticCell wall synthesis inhibitor • 2nd generation

  33. Ceftazidime • Cephalosporin antibioticCell wall synthesis inhibitor • 3rd generation

  34. Ceftriaxone • Cephalosporin antibioticCell wall synthesis inhibitor • 3rd generationCSF penetration

  35. Cefuroxime • Cephalosporin antibioticCell wall synthesis inhibitor • 2nd generationCSF penetration

  36. Cephalexin • Cephalosporin antibioticCell wall synthesis inhibitor • 1st generationOral

  37. Cephalosporins • Antibioticsb lactam • Cell wall synthesis inhibitorsInhibit cross-linking of peptidoglycan

  38. Cephalothin • Cephalosporin antibioticCell wall synthesis inhibitor • 1st generationOral

  39. Chloramphenicol • AntibioticBacteriostatic protein synthesis inhibitor • 50S ribosomeInhibits peptide bond formation

  40. Chloroquine • Antimalarial • Intercalates in DNABinds to ferriprotoporphyrin

  41. Cidofovir • Antiherpes • Pyrimidine analogPhosphorylated to inhibitor of viral DNA polymerase

  42. Ciprofloxacin • Fluoroquinolone antibioticDNA replication inhibitor • Inhibits bacterial DNA gyrase

  43. Cisplatin • Antineoplastic • MiscellaneousCross-linking agent

  44. Clarithromycin • Macrolide antibioticBacteriostatic protein synthesis inhibitor Antiulcer • 50S ribosomeInhibits translocation

  45. Clavulanic acid • b-lactamase inhibitor • Combined with antibacterials

  46. Clindamycin • AntibioticBacteriostatic protein synthesis inhibitor • 50S ribosomeAnaerobic infections

  47. Clotrimazole • Imidazole antifungal • Inhibits synthesis of ergosterolLanosterol 14a demethylase inhibitor

  48. Cloxacillin • Penicillin antibioticCell wall synthesis inhibitor • Penicillinase resistant penicillinInhibits peptidoglycan cross-linking

  49. Cyclophosphamide • Antineoplastic • Alkylating Agent

  50. Cycloserine • AntibioticCell wall synthesis inhibitor • Secondary TB drugInhibits formation of Park nucleotide

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