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NIAID W orkshop on Grantsmanship , Funding, and Peer Review. NIH Structure and Grantsmanship. Alison Deckhut Augustine, Ph.D. Basic Immunology Branch Division of Allergy, Immunology and Transplantation National Institute of Allergy and Infectious Diseases. Presentation Outline.

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Niaid w orkshop on grantsmanship funding and peer review

NIAID Workshop on Grantsmanship, Funding, and Peer Review


Nih structure and grantsmanship

NIH Structure and Grantsmanship

Alison Deckhut Augustine, Ph.D.

Basic Immunology Branch

Division of Allergy, Immunology and Transplantation

National Institute of Allergy and Infectious Diseases


Presentation outline

Presentation Outline

  • NIH Structure and Grantsmanship(Alison)

  • Funding Opportunities (Lawrence Prograis, MD)

  • Grant Application Process/Peer Review (B. Duane Price, PhD)


Nih 27 institutes and centers

NIH – 27 Institutes and Centers

Office of the Director

National Institute

on Aging

National Institute

on Alcohol Abuse

and Alcoholism

National Institute

of Allergy and

Infectious Diseases

National Institute

of Arthritis and

Musculoskeletal

and Skin Diseases

National Cancer

Institute

National Institute

of Child Health

and Human

Development

National Institute on

Deafness and Other

Communication

Disorders

National Institute

of Dental and

Craniofacial

Research

National Institute

of Diabetes and

Digestive and

Kidney Diseases

National Institute

on Drug Abuse

National Institute

of Environmental

Health Sciences

National Eye

Institute

National Institute

of General

Medical Sciences

National Heart,

Lung, and Blood

Institute

National Human

Genome Research

Institute

National Institute

of Mental Health

National Institute

of Neurological

Disorders and

Stroke

National Institute

of Nursing Research

National Institute

on Minority Health

and Health

Disparities

National Center

for Complementary

and Alternative

Medicine

National Center on

Minority Health and

Health Disparities

Fogarty

International

Center

National Center

for Research

Resources

National Library

of Medicine

National Institute of

Biomedical Imaging

and Bioengineering

Clinical Center

Center for

Information

Technology

Center for

Scientific Review

no funding

authority

Different Missions, Responsibilities and Constituencies


A typical nih institute center

A Typical NIH Institute/Center

National

Advisory

Council

Board of

Scientific

Counselors

Office of the IC

Director

Extramural

Intramural

Biomedical Research Contracts

Biomedical Research Grants

Basic & Clinical Research

Clinical Trials


Understanding navigating the nih

Understanding/Navigating the NIH

NIH Extramural

Programs


Nih extramural staff

NIH Extramural Staff

  • Program Officer (PO)

  • Scientific Review Officer (SRO)

  • Grants Management Specialist (GMS)


Program officer

Program Officer

A science professional, usually Ph.D./M.D. level,

who:

Serves as an advocate for investigators

Provides scientific stewardship and administration of grants & contracts awarded by NIH

Identifies areas of scientific priority and develops funding opportunities for extramural researchers

Provides guidance on NIH extramural policy/procedures, research resources, and funding opportunities to extramural investigators


Scientific review officer

Scientific Review Officer

A science professional, usually M.D. or Ph.D. level, who:

Is based at an NIH Institute or Center (IC), or at the Center for Scientific Review (CSR)

Manages Study Sections and review panels for grants and contracts

Selects review panel members

Assigns reviewers to applications

Compiles application summary statements


Grants management specialist

Grants Management Specialist

Business/finance professional who:

Negotiates and awards all grants

Provides fiscal administration of grants

Is the government official on fiscal and policy issues and approvals


Types of nih funding opportunity announcements foas

Types of NIH Funding Opportunity Announcements (FOAs)

FOA: Call for applications in a particular research area of interest to one or multiple NIH Institutes.

Contracts

  • RFP

  • BAA

    Grants

  • Request for Application (RFA)

  • Program Announcement (PA)


Types of nih funding opportunity announcements foas1

Types of NIH Funding Opportunity Announcements (FOAs)

Request for Application (RFA)

  • One application receipt date

  • Set-aside funds

  • Areas of scientific interest indicated, also includes areas not supported by the RFA

  • Awards may have a budget cap

  • Programmatic, Review, and Grants Management contacts


Types of nih funding opportunity announcements foas2

Types of NIH Funding Opportunity Announcements (FOAs)

Program Announcement (PA) – 3 types

  • PA – general type. No set-aside funds or special review. Reviewed in standing study sections, paid with IC “payline” funds

  • PAR – Special review (Special Emphasis Panel) convened, no set-aside funds (paid with IC “payline” funds)

  • PAS – Set-aside funds, may include review by a Special Emphasis Panel


Niaid w orkshop on grantsmanship funding and peer review

When will I get my grant funded?

(well, sometimes it just feels that way…)


Grant writing 101 the big three

Grant Writing 101: The Big Three

  • Can your research move your field forward?

  • Is the field important – will progress make a difference in human health?

  • Can you and your team conduct the work (expertise, resources)?


Niaid w orkshop on grantsmanship funding and peer review

Grant Writing 101

  • Read FOA instructions thoroughly

  • Never assume the reviewers will “know what you mean”

  • Refer to literature thoroughly

  • State rationale of proposed studies

  • Include well-designed tables and figures

  • Present an organized, clear story


Niaid w orkshop on grantsmanship funding and peer review

Common Grant Writing Mistakes

  • Lack of new or original ideas; incremental advances

  • Absence of a solid scientific rationale

  • Insufficient knowledge of relevant published work

  • Diffuse, superficial or unfocused research plan or

  • experimental approach

  • Proposed studies are too broad or too narrow

  • Limited/no experience in essential techniques, no collaborators with required expertise

  • Lack of discussion of possible pitfalls and alternative approaches

  • Uncertainty concerning future directions


A little help from your friends

A Little Help From Your Friends

  • NIH extramural staff:

    • SRO – advice about appropriate study sections; submission requirements

    • PO - advice about research focus (before review), appropriate study sections, discussion of review results and applicant responses

  • Colleagues: read your application, well in advance of the application due date

  • GRIP: Grant Review for Immunologists Program

    • Matches new PIs with established PIs in same area

    • Obtain expert advice on grant application

      http://www.aai.org/Education/GRIP/index.html


Niaid w orkshop on grantsmanship funding and peer review

Mechanisms (Funding Opportunities)

Lawrence Prograis, M.D.

Division of Allergy, Immunology and Transplantation


Phd career track and niaid funding mechanisms

PhD Career Track and NIAID Funding Mechanisms

  • T32 - Institutional training grant (NRSA)-has pre- & postdoc slots

  • F31 - Individual (diversity) predoc fellowship (NRSA)

  • F31 – Individual Predoctoral Fellowship (NRSA) [FY2015 available]

  • F32 - Individual postdoc fellowship (NRSA)

  • K01- Mentored Research Scientist Award

  • K22 - Research Scholar Development Award

  • K99/R00 - Pathway to Independence Award

T32

F31

T32

F32

K01

K99

R00

K22

Award

Types

or

High

School

Student

Graduate

Student

Ph.D.

Faculty

Position

Independent

Investigator

Postdoc Phase

Career

Stage

Diversity Supplements


Md career track and niaid funding mechanisms

MD Career Track and NIAID Funding Mechanisms

  • T35 - NRSA Short Term Institutional Research Training Grant

  • F30 - Individual predoctoralMD/PhD and Other Dual Doctoral Degree Fellows (NRSA)

  • T32 - Institutional training grant (NRSA)-has pre-& postdoc slots

  • F32 - Individual postdoc fellowship (NRSA)

  • K01 - Mentored Research Scientist Award

  • K08 - Mentored Clinical Scientist Research Career Development Award

  • K23 - Mentored Patient-Oriented Research Career Development Award

  • K24 - Mid-Career Investigator Award in Patient-Oriented Research

  • K22- Research Scholar Development Award

K01

K08

K23

Award

Types

T35

T32

F32

K24

F30

Medical

Student

M.D.

Clinical

Training

Phase

Research

Training

Phase

Faculty

Position

Independent

Investigator

Diversity Supplements


Niaid fellowship awards fs

NIAID Fellowship Awards (Fs)

F30: started FY14

  • Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral MD/PhD and Other Dual Doctoral Degree Fellows (Parent F30)

    F31 (Div):

  • Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellowships to Promote Diversity in Health-Related Research (Parent F31 - Diversity)

    F32:

  • Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Postdoctoral Fellows (Parent F32)

    FY15: Sign on to F31:

  • Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellows


Individual fellowship awards fs

Individual Fellowship Awards (Fs)

  • Individual awards

  • Cannot change the scope, move fellowship, or change mentor without prior NIH approval

  • NIH determines stipend levels and limited tuition reimbursement, training related expenses; F&As 8%

    • Review at CSR (currently 24 SS)

    • http://public.csr.nih.gov/StudySections/Fellowship/Pages/default.aspx

    • Success rate < 20%


Niaid career development awards ks

NIAID Career Development Awards (Ks)

K08:

Mentored Clinical Scientist Research Career Development Award (Parent K08)

K23:

Mentored Patient-Oriented Research Career Development Award (Parent K23)

K24:

Midcareer Investigator Award in Patient-Oriented Research (Parent K24)

K22 (PAR):

NIAID Career Transition Award (K22)

K99/R00:

NIH Pathway to Independence Award (Parent K99/R00)

NIAID supports only 1 year of a mentored phase (K99) and 2 years of the independent (R00) phase. This is a deviation from the support from all the other ICs.

K01:

Mentored Research Scientist Development Award (Parent K01)

NIAID Career Development (K01) Awards in Epidemiology, Modeling, and Outcomes Research

http://grants1.nih.gov/grants/guide/notice-files/NOT-AI-08-040.html

K25:

Mentored Quantitative Research Development Award (Parent K25)


Career development awards ks

Career Development Awards (Ks)

  • Individual awards

  • MDs (K08 and K23) to support development to become independent investigators

  • K24 (associate professor)**supports mentoring of young clinical investigators

  • Salary for K08/23 awards: $90K/$50K research support; F&A 8%

  • Most are mentored, others are not

  • PhDs (MDs): Mostly K22 and K99/R00: transition awards; also K01 and K25

  • Review at NIAID SRP by 4 chartered committees (AIDS, AITC, MID and MID-B)

    • Candidate, Career Dev. Plan, Research Plan, Mentor(s), Env./Inst. Com.

  • Success rates about 30+%


Postdoc phd md should i apply for a k22 or a k99 r00

Postdoc (PhD/MD) – Should I apply for a K22 or a K99/R00?

  • NIAID Research Scholar Development Award (K22)

  • Transition award (postdoc-to-assistant professor)

  • 2 year award

  • No mentored phase. Fundable score, s/he has one year to find a position as assistant professor

    Phase 2:

    • Assistant Professor position

    • Own lab space

    • Significant start-up funds

    • Little teaching/ no administrative responsibilities

  • $150K (Year 1) + $100K (Year 2)

  • Success rate: >25%

  • NIAID’s Pathway to Independence

    Award (K99/R00)

  • Transition award (postdoc-to asst. professor)

  • 3 year award (other ICs 5yrs)

  • 1 yr mentored phase ($90K/yr)

  • Awardee becomes assistant professor (internal approval similar to K22 phase 2)

  • 2 yr independent R00 phase ($249K/yr TC)

  • No US citizenship required

  • Success rate: ca. 7-18%


Niaid transition awards k22 or k99 r00

NIAID Transition Awards (K22 or K99/R00)

Postdoc with less than 4 years of

postdoc experience

Assistant Professor

+/- 1 year

Secures a faculty

Position

&

Submits the K22 phase II

or R00 application

NIAID makes the award to the new

institution/candidate.

Submits a K22 or

K99 application

and receives a

fundable score


Success rates for niaid training and career grants fy2012

Success Rates for NIAID Training and Career Grants, FY2012


Niaid training pay lines

NIAID Training Pay lines


Loan repayment programs lrp

Loan Repayment programs (LRP)

  • NIH wants to encourage outstanding health professionals to pursue careers in biomedical, behavioral, social, and clinical research. If you commit at least two years to conducting qualified research funded by a domestic nonprofit organization or U.S. federal, state, or local government entity, NIH may repay up to $35,000 of your qualified student loan debt per year. Loan repayment benefits are in addition to the institutional salary you receive for your research.

  • Clinical Research

  • Pediatric Research

  • Health Disparities Research

  • Contraception and Infertility Research

  • Clinical Research LRP for Individuals from Disadvantaged Backgrounds

  • General LRP site:

    • http://www.lrp.nih.gov/index.aspx

    • A recorded overview webinar from the LRP Office: http://go.usa.gov/aHx


Nih websites

NIH WEBSITES

  • Training at NIH

    • http://www.training.nih.gov

  • NIH Research Training Opportunities

    • http://grants1.nih.gov/training/extramural.htm

  • NIH Guidelines and Forms

    • http://www.nih.gov/grants/documentindex.htm

  • NIAID Advice on Training

    • http://www.niaid.nih.gov/ncn/training/default.htm

  • How to Write a Grant

    • http://www.niaid.nih.gov/ncn/grants/write/index.htm


Non nih research funding websites

Non-NIH Research Funding Websites

  • Fogarty International Center: http://www.fic.nih.gov/funding/index.htm

  • National Science Foundation (NSF): http://www.nsf.gov/

  • FastLane: http://www.fastlane.nsf.gov/fastlane.jsp

  • Defense Advanced Research Projects Agency (DARPA) http://www.darpa.mil/

  • The Congressionally Directed Medical Research Programs (CDMRP) http://cdmrp.army.mil/


Research support funding websites

Research Support Funding Websites

  • Bill and Melinda Gates Foundation: http://www.fgatesfoundation.org/default

  • The Wellcome Trust: http://www.wellcomefund.ac.uk/

  • The Global Fund to Fight AIDS, Tuberculosis and Malaria: http://www.theglobalfund.org/en/

  • amfAR, the American Foundation for AIDS Research:http://www.amfar.org/

  • The International AIDS Vaccine Initiative: http://www.iavi.org/

  • The Alfred P. Sloan Foundation: http://www.sloan.org/

  • Centers for Research Libraries (includes dissertations):

  • http://www.crl.edu/catalog/index.htm


Private funding sources national and international

Private Funding Sources:(National and International)

A short list of NIAID's List of Foundations and Other Funding sources at:

  • http://www.niaid.nih.gov/researchfunding/ann/Pages/found.aspx


Niaid w orkshop on grantsmanship funding and peer review

NIH Peer ReviewB. Duane Price, PhDSenior Scientific Review OfficerImmunology Review Branch,Division of Extramural Activities, NIAID


Application processing

Application Processing

*

CSR assigns applications to study section (review) & NIH Institute (funding)

Researcher writes and

Institution submits application to NIH

Summary Statement and Priority Score transmitted to applicant (Commons) and NIH extramural staff

Study section composed of 20-30 reviewers – review/discuss applications

3- 4 reviewers assigned to read and write critiques for each application


Mock peer review

Mock Peer Review

  • Sample R01 Applications and Summary Statements http://www.niaid.nih.gov/researchfunding/grant/pages/appsamples.aspx

  • NIH Grant Review Process YouTube Videos http://cms.csr.nih.gov/ResourcesforApplicants/InsidetheNIHGrantReviewProcessVideo.htm


Nih scoring range

NIH Scoring Range


Understanding the summary statement

Understanding the Summary Statement

  • Impact/Priority Score: 1-9 scale

  • Percentile: Approximate percentage of applications receiving an impact/priority score from the study section during one year (3 review cycles), NOT all types of grants receive a percentile

  • Resume: Official summary of review meeting discussion, for scored applications only

  • Critiques: Reviewers written comments


What to do after review

What to Do After Review

  • Talk to your NIH Program Officer

    • Attends the Study Section (most cases)

    • Provide insights to discussion (unofficial) and possible funding options

  • Read the Summary Statement

    • Official document providing scientific merit score and summarizing reviewers comments

    • First paragraph (Resume) is the official summary of the meeting discussion

  • Strategize Next Steps

    • Talk to your NIH program officer again,

      after both of you have read the summary statement

    • Discuss with colleagues, mentors


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