Tumor formation in nude mice injected by oncogenic
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PARP-1+/+ p53-/- PowerPoint PPT Presentation


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Tumor formation in nude mice injected by oncogenic ras -transduced primary (PARP-1-/-; p53-/-) MEFs is considerably delayed. + Matrigel. 6. 0. 0. PARP-1-/- p53-/-. 5. 0. 0. PARP-1+/+ p53-/-. PARP-1+/+ p53-/-. 4. 0. 0. Tumour volume (mm 3 ). 3. 0. 0. PARP-1-/- p53-/-. 2.

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PARP-1+/+ p53-/-

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Parp 1 p53

Tumor formation in nude mice injected by oncogenic ras-transduced

primary(PARP-1-/-; p53-/-)MEFs is considerably delayed

+ Matrigel

6

0

0

PARP-1-/-

p53-/-

5

0

0

PARP-1+/+

p53-/-

PARP-1+/+

p53-/-

4

0

0

Tumour volume (mm3)

3

0

0

PARP-1-/-

p53-/-

2

0

0

1

0

0

0

0

5

1

0

1

5

2

0

2

5

Time (days)

Conde, C. et al. (2001) EMBO J. 20, 3535-43


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