SPEX SamplePrep Equipment Lineup

1. SPEX SamplePrepEquipment Lineup

2. Product Lines • Freezer/Mill • Geno/Grinder • Presses • Mixer/Mill • Shatterbox • XRF accessories

3. Freezer/Mills ® 67706870

4. What is Cryogenic Grinding? • The Ultimate Sample Preparation Technique for Pulverizing “ Difficult ” Samples • Grinding materials at low temperatures. • Liquid Nitrogen –196°C

5. Why Cryogenic Grinding? Have difficult samples to prepare? You tried every technique in your laboratory and nothing works? Feel that nothing in this world will grind your samples?

6. Advantages: • “Ungrindable” samples can be pulverized • Leaves, roots, stems, seeds (cotton, sunflower, corn) • Polymers, rubber, silicones • Fibers, hair, textiles • Skin, bone, muscle, cartilage, etc • Food products, paint chips, pharmaceuticals • Gums, resins, waxes • Electronic components • Tough food, feed materials (dog chews)

7. Before & After… Leather Corn A Collection of our Before & After Samples Bone

8. 6770/6870Freezer/Mill® (Biotechnology) & Numerous other applications • Spex SamplePrep freezer mills are the only true “Cryogenic Mills” on the market for over 40 years. • Utilized for grinding fresh plant and animal tissue for nucleic acids (RNA/DNA), forensics, GMO analysis and genetic research • Useful tool for pharmaceutical analysis, drug testing,medical research, polymers and plastics. • RoHs/WEEE testing

9. 6770/6870 Freezer/Mill® : Features & Benefits • Cryogenic mills which chill samples to liquid nitrogen temperatures (-196C) • Magnetically driven impactor is the only moving part • No mechanical linkages or bearings to fail • Grinding vials are sealed so sample integrity is maintained during grinding cycle • Equip with speed control, programmable timer, and safety interlock. • Sample sizes from 0.1g to 50g

10. 6770/6870 Freezer/Mill® : Features & Benefits • Integral LN reservoir maintains cryogenic temperatures • Programmable LCD Touch Screen Controls • Multiple User Memory Settings • The only mill to grind samples in LN. This ensures optimum sample brittleness for best results • Has integral pre-cooling positions (reduced LN consumption, safe storage of ground samples, no external chilling equipment needed) • Auto-fill option (6870 only)- time saving and increased safety • Low cost vials with easy sample extraction-important for forensic and pharma customers who need disposable vials • Several vial options, micro vials, regular, mid size and large

11. Applications/where to sell • Forensic Labs –DNA identification • Medical Laboratories –genetic research, disease prevention • Hospital Labs – For genetic screening (oncology, etc) • Agricultural Labs – For crop development and GM testing • Agricultural Veterinary Labs – For livestock breeding and health • Archaeology Labs – Ancient DNA Extraction • Public Health and Environmental Monitoring Laboratories • Contract/commercial testing labs QC of manufactured goods • Electronics Companies – grinding electronic components

12. Freezer mills 6770 & 6870Applications and Markets Other new markets and opportunities • Electronics companies - grinding soft metals (Aluminium, Zinc) • Pharmaceutical companies – grinding capsules and whole tablets • Dentistry - grinding amalgams, resins • Food safety– toxicity testing • Phthalates in plastics - new regulations

13. New CPSC Guidelines for Determination of Phthalates in Plastics • Consumer Product Safety Commission (CPSC) standard operating procedure for determining phthalates in plastics in children’s toys • Operating procedure recommends the use of cryogenic grinding to prepare samples • Cryogenic grinding can pulverize samples down to a fine powder of less than 500 microns • Creates homogenous sample with a larger surface area improving the extraction process.

14. Freezer/Mill in Action 6770 in CSI Miami (Season 7 Ep. 2) Used in studies of Moon Rock

15. Geno/Grinder ® 2010

16. 2010 Geno/Grinder® (Biotechnology) • The 2010 Geno Grinder was specifically designed for Pioneer Hybrid International • “A World Leader in genetic crop science”. • The Geno/Grinder provides a mechanism for efficient cell disruption of plant and animal tissue for the isolation of nucleic acids (RNA/DNA), enzymes, yeast and proteins. • The versatile sample clamping mechanism can also hold micro-tubes, racked tubes, specially designed 5 ml vials, 15ml and 50 ml standard conical tubes using the optional large capacity clamp adapter.

17. 2010 Geno/Grinder®:Features & Benefits • NEW FEATURES • Modern, streamlined look • Smaller footprint • Lighter • LCD Display • Improved reliability of wear parts • Unique true vertical action – ensures complete sample processing. • Sample clamp accepts multiple micro titer-plates, various vials from 0.6ml to 50ml vials - wide application range. • Adjustable speed control and timer (with countdown display) for optimum results. • Wide range of cryogenic accessories • Wide range of grinding media

18. 2010 Geno/Grinder®: Accessories • Cryo-Station • – A holding station for temperature sensitive samples such as proteins and pesticides • Cryo-Adapter • – A single piece of extruded aluminium to be chilled and then inserted into a 2210 96-well Titer Plate • CryoBlocks • Aluminium blocks designed to hold samples for chilling in the Cryo-station. Cryo-Blocks come in a variety of holding sizes including 0.6 mL & 2.0 mL PCR tube capacity. • Cryovials • PC and PE centrifuge tubes specifically designed to resist breaking at low temperatures. Ideal for grinding temperature sensitive samples. • Kryo-Tech® accessories

19. 2000 Geno/Grinder Applications 2010 Geno/Grinder® • Rapid preparation of multiple samples for PCR sampling • Fast disruption to allow extraction of Nucleic acids • High-throughput in a 96-well format and various other formats up to twelve 50mL centrifuge tubes • Lysing of bacterial cells • DNA screening for disease control • Pesticide analysis

20. Where to Sell Markets • Basically – any institution using high throughput DNA sample processing • Plant and Animal development companies • Agricultural and public health labs (disease screening). • Pesticide residues • Micro toxins Look for synergy! - DNA sequencing equipment, Cell washing equipment, Microplate sealing equipment.

21. 2010 Geno/Grinder® QuEChERS Method • Plant tissue from Fruits and Vegetables are homogenized and mixed with QuEChERS reagents using Geno/Grinder & ceramic grinding media • Can be homogenized at room temperature or with Kryo-Tech® accessories • Up to 16 x 50ml vials can be processed simultaneously • Increases pesticide yields • Improves reproducibility • Used by FDA QuickEasyCheapEffectiveRuggedSafe

22. Geno/Grinder – Sales Focus • Primarily high-throughput users • Capital costs are easily countered by time savings • Multiple sample format flexibility • Appeals to a broad spectrum of users and applications • Pedigree of existing users • Name drop – use the reference list to its full benefit • Profile of existing users • Look for similarities between current and potential users Example Customers: Danish Institute of Agricultural Science | Planta, Germany Pioneer, France | Monsanto, UK | Syngenta, UK Rijk Zwaan, Netherlands | Enza Zaden, Netherlands Pioneer Hybrid, USA | Du Pont, USA | Promega, USA US Dept. of Agriculture | Aventis Crop Science, USA| Merck, USA

23. X-Press ® & Bench-Press ® 3635/3628

24. Presses

25. 3635 X-Press® • New anodized look with the same rugged reliability • The X-Press is a 35 ton fully automated hydraulic press used for spectroscopic techniques requiring samples in the form of round, flat-surfaced discs, most commonly XRF • SPEX SamplePrep presses and dies are sophisticated in design, but functionally simple and provide years of maintenance-free operation. New!

26. 3635 X-Press® • Now featuring a programmable LCD touch screen • Fully Programmable - Final pressure desired, time to hold at final pressure, and intervals to return back to zero pressure • Typical pressing cycle is less than two minutes • A safety interlock and automatic pump shut-off safety valve ensure safe operation • Compact, bench top operation • Accepts all competitors die sets • CE marked Features and Benefits

27. The 3628 Bench-Press is an air-actuated, manually controlled 25-ton laboratory press. This Bench-Press is compact Very simple controls It includes a safety door with interlock, CE-marked Accepts most other “ stand-alone” pellet dies. Good for spark free environments 3628 Bench-Press ®

28. X-Press ® & 3628 Where to Sell • Users of XRF instruments • Universities – notably Geology Depts. • Cement manufacturing • Any industrial facility requiring analysis or processing pelletized samples • Markets and customers similar to Shatterbox and Mixer mills Look for Synergy ! (work with XRF supplier offices / sales reps in your regions)

29. Mixer/Mill 51008000M8000D

30. Pulverizing & Blending Can hold up to 3 small vials 20 g sample using two vials

31. 8000M Mixer/Mill • Efficient laboratory mill for pulverizing hard, brittle samples • Often described as a shaker mill or high-energy ball mill • Capable of rapidly reducing solids to analytical fineness or blending a wide range of powders • Effective for mechanical alloying, well documented in literature “SPEX Mill” • Extended run times • Membrane control panel • Built in Fan for cooling

32. Mixer/Mills Features & Benefits • Mixer/Mill is only ball mill that can be used for efficient Mechanical alloying. • Figure of Eight motion has been proven to be more efficient than side-to-side or planetary motion found in other mills • Extremely robust • Large range of grinding vial materials and size • Competitively priced

33. Mixer/Mills • Universities, geology ,materials science, engineering departments • Industrial laboratories - cement, slag, ceramics, catalysts • Pharmaceutical companies (Blending, polymers) • Rock Labs • Electronics (mechanical alloying) • Petroleum companies • Corn milling method G-11 Hexane extraction method • http://corn.org/methods/G-11.pdf Where to Sell

34. Shatterbox ® 8530

35. Shatterbox ® 8530 • The Shatterbox is the most popular “swing mill” in America • It is the most efficient way to grind brittle samples to analytical fineness • The Shatterbox swings a dish-shaped grinding container with a puck and ring, in a tight high-speed circle • Fast grinding times

36. Shatterbox ® 8530 Features & Benefits • Resultant particle size well below 200 mesh; with proper grinding aid, less then 10 microns • Wide choice of grinding container material and size • Clamp requires only moderate hand pressure to secure grinding dish and is adjustable to secure containers of different heights • Vial transporter available • Soundproof enclosure, variable-range electronic timer, lockable casters & safety interlock system • Membrane control panel resistant to airborne particles

37. Shatterbox ® 8530 • Same markets as mixer/mills • Notably mining operations (prefer larger samples sizes) • Pharmaceuticals, dried marsh grass, and many other materials Where to Sell

38. XRF Accessories • Spec-Caps ® • Shallow, thin-walled aluminum cups routinely used to produce pressed-powder sample discs for XRF. Sizes available for all die sets. • X-Cells for XRF Liquid Samples • Patented closed X-Cell design prevents spillage in inverted XRF spectrometers. Sizes to fit most instruments. • Thin Film Windows for XRF • Necessity for X-Cell liquid sample cell, serving as a the sample window. Different types available based on sample characteristics. Eg Mylar ®

39. Provide a high profit margin and continuous revenue stream Let users have samples – we can provide sample packs for trial with key potential users Look for synergy with XRF instrument manufacturers & suppliers Bulk quantities available for lower price XRF Accessories Features & Benefits

40. Thanks for your attention