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8636 bp

Supplemental Fig. 1. TG (10 nM ). TG (100 nM ). 8636 bp. 18s. 0 1 3 6 12 24. 0 1 3 6 12 24 (hr). Supplemental Fig. 2. CHOP. CHOP. CHOP. GRP78. GRP78. GRP78. GRP94. GRP94. GRP94.

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8636 bp

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  1. Supplemental Fig. 1 TG (10 nM) TG (100 nM) 8636 bp 18s 0 1 3 6 12 24 0 1 3 6 12 24 (hr) Supplemental Fig. 2 CHOP CHOP CHOP GRP78 GRP78 GRP78 GRP94 GRP94 GRP94 0 5 50 500 0 0.1 1 0 0.1 0.2 0.5 homocysteine (mM) palmitate (mM) TM (ng/ml) Supplemental Fig. 3 * * * mtDNA/nDNA (arbitrary unit) mtDNA/nDNA (arbitrary unit) mtDNA/nDNA (arbitrary unit) 8636 bp 8636 bp 8636 bp 18s 18s 18s palmitate(mM) 0 0.1 0.2 0.5 TM (ng/ml) 0 5 50 500 homocysteine (mM) 0 0.1 1

  2. Supplemental Fig. 4 HepG2 cell U937 cells A HO-1 HO-1 PGC1α PGC1α NRF-1 NRF-1 TFAM TFAM 18s 18s TG ( nM) - 10 100 TG (10nM ) 0 3 6 12 18 24 B XBP-1 XBP-1 CHOP CHOP GRP78 GRP78 18s 18s TG (10nM ) 0 3 6 12 18 24 TG ( nM) - 10 100

  3. A 8636 bp 18s TG (100 nM) - + + + + - Hb (mg) - - 5 10 20 20 Supplemental Fig. 6 8636 bp 18s Supplemental Fig. 5 TG (100 nM) - + + + + ZnPP (mM) - - 5 10 20 A PERK-/- WT 8636 bp 18s TG (nM) - 10 100 - 10 100 B

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