Fast geometric consensus approach for protein model quality assessment
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Fast Geometric Consensus Approach for Protein Model Quality Assessment. Jaroslaw Meller, University of Cincinnati College of Medicine Published at Journal of Computational Biology, 2011. Presented by Chao Wang. Motivation & Background. Template selection and Model selection for CASP

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Fast geometric consensus approach for protein model quality assessment

Fast Geometric Consensus Approach for Protein Model Quality Assessment

Jaroslaw Meller, University of Cincinnati College of Medicine

Published at Journal of Computational Biology, 2011

Presented by Chao Wang


Motivation background
Motivation & Background Assessment

  • Template selection and Model selection for CASP

  • True (individual) MQA and Consensus MQA

  • F=U-TS

    • F: Free Energy

    • U: Internal Energy

    • T: Temprature

    • S: Entropy

  • All happy families are alike but unfortunate families each are not identical. --Leo Tolstoy ``Anna Karenina''


Introduction
Introduction Assessment


Methods
Methods Assessment

  • How to define

  • How to calculate

  • Data sets


Methods1
Methods Assessment


Data sets
Data sets Assessment


Results
Results Assessment


Conclusion
Conclusion Assessment

  • ……


Chao s comments
Chao's comments Assessment

  • Chao's perspective:

    • All methods which not distinguishing templates are not efficient.

  • CLE rather than SS

  • D-score is higher complexible on the length of structure

  • Merge true QA and consensus QA in our SVM

  • Effect from templates


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