Absorptive Kinetics of Transdermal Fentanyl. Robert Leonard, PharmD candidate University of Florida College of Pharmacy. Overview. Rationale Barriers TTS-fentanyl Pharmacokinetics Studies of pharmacokinetic variability. Rationale. Continuous infusion Noninvasive nature
Robert Leonard, PharmD candidate
University of Florida
College of Pharmacy
Ashburn MA, Ogden LL, Zhang J, et al. “The pharmacokinetics of transdermal fentanyl delivered with and without controlled heat.” The Journal of Pain 4: 291-297, 2003.
Grond S, Radbruch L, Lehmann K. “Clinical pharmacokinetics of transdermal opioids: Focus on transdermal fentanyl.” Clinical Pharmacokinetics 38: 59-89, 2000.
Muijsers RB, Wagstaff AJ. “Transdermal fentanyl: An updated review of its pharmacological properties and therapeutic efficacy in chronic cancer pain control.” Drugs 61:2289-2307, 2001.
Solassol I, Caumette L, Bressolle F, et al. “Inter- and intra-individual variation in transdermal fentanyl absorption in cancer pain patients.” Oncology Reports 14:1029-1036, 2005.