Hypoxia
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Hypoxia. The Department of Pathophysiology Guo lirong. Hypoxia. Main points to study. Definition of hypoxia (What is hypoxia?) Parameters of Blood Oxygen. Hypoxia. External respiration. Tissue cells. Blood. Circulation. Oxygen Supply. Oxygen Utilization. Hypoxia. Definition.

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Hypoxia

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Hypoxia

Hypoxia

The Department of Pathophysiology

Guo lirong


Definition of hypoxia what is hypoxia parameters of blood oxygen

Hypoxia

Main points to study

Definition of hypoxia (What is hypoxia?)

Parameters of Blood Oxygen


Hypoxia

Hypoxia

External

respiration

Tissue

cells

Blood

Circulation

Oxygen

Supply

Oxygen

Utilization


Hypoxia

Hypoxia

Definition

Hypoxia is the commonest pathological process,which is defined as that cells can not obtain enough oxygen or can not fully utilize oxygen,thus leading to changes in their metabolism,function,or structure.


Hypoxia

Hypoxia

Parameters of Blood Oxygen

1.Partial pressure of oxygen(PO2)

2.Oxygen binding capacity(CO2 max)

3.Oxygen content(CO2)

4.Oxygen saturation( SO2)


Hypoxia

Hypoxia

Partial pressure of oxygen(PO2)

1.Definition:the tension produced by oxygen molecules physically dissolved in plasma.

2.Normal value:PaO2=13.3kPa(100mmHg)

PvO2=5.33kPa(40mmHg)


Hypoxia

Hypoxia

Oxygen binding capacity (CO2max)

1. Definition:It is the maximum amount of oxygen that can be combined to hemoglobin in 100 ml of blood.

2.Normal value:20ml/dl


Hypoxia

Hypoxia

Oxygen content(CO2)

1.Definition:It is the actualcontent of oxygen in 100ml blood.

2.Normal value:CaO2=19ml/dl

CvO2=14ml/dl


Hypoxia

19ml/dl

14ml/dl

A

V

O2

O2

O2

O2

O2

5ml/dl

Arteriovenous oxygen content (Ca-vO2)

Definition:It is the difference of oxygen content between arterial blood and mixed venous blood.

Normal value: 5ml/dl


Hypoxia

  • CO2-dissolved O2

  • CO2max

SO2

=

100%

Hypoxia

Oxygen saturation (SO2)

Definition:It is the percentage of hemoglobin present as oxyhemoglobin.

Normal value:SaO2=95%; SvO2=70%


Hypoxia

P50

Definition:P50 is a parameter reflecting the affinity of Hb to oxygen; it is the O2 pressure required to sturate 50% of Hb.

Normal value:26~28 mmHg


Hypoxia

100

80

60

40

20

20

40

60

80

100

Dissociation curve of oxyhemoglobin

Hypoxia

Leftward-shifted curve:

Hb Saturation (%)

Rightward-shifted curve

pH↓

2,3-DPG↑

CO2↑

Temperature↑

PaO2 (mmHg)


Hypoxia

Thank you


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