Epigenetica e cancro
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Epigenetica e Cancro. Pier Mario Biava Istituto di Ricovero e Cura a Carattere Scientifico Multimedica Milano. MOLECULAR WEIGHT OF DIFFERENT PROTEINS PRESENT IN ZEBRAFISH EMBRYO DURING GASTRULATION PERIOD. 1) 37% molecular weight of about 97KDa 2) 14.6% molecular weight of about 45 KDa

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Epigenetica e Cancro

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Epigenetica e cancro

Epigenetica e Cancro

Pier Mario Biava

Istituto di Ricovero e Cura a Carattere Scientifico Multimedica Milano


Epigenetica e cancro

MOLECULAR WEIGHT OF DIFFERENT PROTEINS PRESENT IN ZEBRAFISH EMBRYO

DURING GASTRULATION PERIOD

1) 37% molecular weight of about 97KDa

2) 14.6% molecular weight of about 45 KDa

3+4) 27.4% molecular weight of about 30-25 KDa

5) 4% molecular weight of about 20 KDa

6+7) 14% molecular weight of about 14 KDa


Epigenetica e cancro

Continues


Epigenetica e cancro

Spiral CT during the arterial phase prior to treatment withstem cell differentiation stage factors(SCDSF) shows an advanced HCC of the right lobe. Neoplastic hypervascularized areas are present in segment 7, and a hypervascularized thrombus (arrow) occupies the right portal branch and reaches the main trunk.


In the same patient power doppler confirms the thrombosis inside the main portal vein asterisk

In the same patient, power doppler confirms the thrombosis inside the main portal vein (asterisk)


Epigenetica e cancro

Spiral CT performed 6 months after treatment with SCDSF shows the shrinkage of portal thrombus and disappearance of HCC in the right lobe


Power doppler confirms the shrinkage of the thrombosis and the patency of the main portal vein

Power doppler confirms the shrinkage of the thrombosis and the patency of the main portal vein


In another case ct during arterial phase prior to treatment with scdsf shows several nodules of hcc

In another case, CT during arterial phase prior to treatment with SCDSF shows several nodules of HCC


Epigenetica e cancro

CT performed 6 months after treatment with SCDSF shows the disappearance of neoplastic hypervascularization inside the nodules


Epigenetica e cancro

Treatment with stem cell differentiation stage factors of

intermediate-advanced HCC: an open randomized clinical trial.

100

80

60

Survival (%)

40

20

Objective response & stable disease

Progression

0

0

6

12

18

24

30

36

Months

Livraghi T, Meloni F, Frosi A et al. Oncol Res 2005


Epigenetica e cancro

Analisi delle proteine degli estratti di zebrafish:

5 fasi di sviluppo (ZF1-ZF5) e una mix delle 5 fasi (ZF6)

SDS Page degli estratti embrionali di Zebrafish


Saggio di proliferazione

Saggio di proliferazione:

estratti di zebrafish: 6 fasi (ZF1-ZF6) a 4 concentrazioni,

dopo 24 ore di trattamento

Saggio di proliferazione


Saggio di proliferazione1

Saggio di proliferazione:

estratti di zebrafish: 6 fasi (ZF1-ZF6) a 4 concentrazioni,

dopo 72 ore di trattamento

Saggio di proliferazione

p < 0,05

p < 0,01


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