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ARTHRITIS. Rheumatoid Arthritis Presented By: Ali Raza Ansar Qudsia Sehar Hafsa Kabir. Introduction. Joint disorder that cause inflammation Over 100 types of Arthritis Most Common is Rheumatoid Arthritis and osteoarthritis, both are autoimmune diseases. Symptoms

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ARTHRITIS

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ARTHRITIS

Rheumatoid Arthritis

Presented By:

Ali RazaAnsar

QudsiaSehar

HafsaKabir


Introduction

  • Joint disorder that cause inflammation

  • Over 100 types of Arthritis

  • Most Common is Rheumatoid Arthritis and osteoarthritis, both are autoimmune diseases.

  • Symptoms

    • Inability to use the hand or walk

    • Malaise and a feeling of tiredness

    • Weight loss

    • Poor sleep

    • Muscle aches and pains

    • Tenderness

    • Difficulty moving the joint


Biology Of Rheumatoid Arthritis

  • Genetic Basis of RA:

    • HLA genes: HLA-DR1 and DR4 are associated with disease

    • PDAI: Peptidyl arginine deaminase gene

    • PTN22 gene: Regulates kinases

  • Autoantibodies:

    • Rh factor: Antibody, binds to the Fc region of IgG.


    • ACPA: Anti-citrullinated protein antibody, MHC class-II, specially bearing “shared epitope” bind efficiently with citrullinated proteins. An immune response is triggered producing ACPA.

  • Inflammation and bone deformity:

    • Different cytokines are involved

    • IL-1, IL-6 and TNFα are important

    • Normal bone remodeling

      • Osteoblasts

      • Osteoclasts

  • NF-κB plays significant role in RA pathogenesi

  • Role of estrogen


  • Diagnosis of ArthritisDiagnostic Tools

    • Physical Examination

    • Laboratory Tests

    • Medical Imaging


    Laboratory Tests

    • Rheumatoid factor

    • Erythrocyte sedimentation Rate

    • C-reactive protein

    • Anti-cyliccitullinatedPeptide Antibody Test

    • Antinuclear Antibodies

    • Compete blood count


    Treatment

    • Drug treatment

    • Occupational/physical therapy

    • Surgery

    • Biologics


    Drug Treatment

    • Pain killers

    • NSAID’S (non-steroidal anti inflammatory drug)

    • Cox-2 inhibitors

    • Gold injections


    • Physical therapy

    • Surgery

      Performed when patients are non-responsive for treatment


    Biotechnological Applications in Treatment

    • Biologics

      • Use specifically for rheumatoid arthritis

      • Target specific

        • Act only on immune system

      • Anti- t.f is an example


    Current Research Projects

    • DEVELOPMENT OF ANTISENSE THERAPY OF ARTHRITIS

    • DEVELOPMENT OF A BIOMARKER FOR RA


    Development of Antisense Therapy of Arthritis

    • Developed by BGN technologies

    • Target cPLA-2

    • Inhibits the synthesis of c-PLA 2 ENZYME


    Development of a Biomarker For RA

    • RA biomarker based on 14-3-3η protein

    • It is an intracellular protein

    • Suffering from RA it is involved in joints deformation and is released inside joints


    QUESTIONS


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