Research Misconduct. It ’ s a Matter of Public Trust. Gretchen Brodnicki, J.D. Dean for Faculty and Research Integrity Dennis Brown, Ph.D. Professor of Medicine Director, ORCD March 25, 2014. Faculty Disclosures. Pfizer pays GB ’ s mortgage DB – I wish!. Agenda. Research Misconduct
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It’s a Matter of Public Trust
Gretchen Brodnicki, J.D.
Dean for Faculty and Research Integrity
Dennis Brown, Ph.D.
Professor of Medicine
March 25, 2014
Nature Medicine 11, 464 (2005) doi:10.1038/nm0505-464Profile: Woo-Suk Hwang
suggesting a link between MMR vaccine and autism
Science, “Poehlman Sentenced to 1 Year of Prison,” by Eli Kintisch on 28 June 2006.
Photo from The Telegraph, , March 27, 2008(“MMR-autism link doctor Andrew Wakefield defends conduct at GMC hearing”)
Duke – Anil Potti
Photo by Inside Duke Medicine, February 24, 2010
Fang et al., PNAS, 2012
What\'s in a picture? The temptation of image manipulation
Rossner and Yamada 166 (1): 11Published July 6, 2004 // JCB vol. 166 no. 1 11-15
Rossner M , Yamada K M J Cell Biol 2004;166:11-15
Navigating through the gray (and CMYK) areas of figure manipulation: rules at the J. Clin. Invest.
L. A. Turka. Editor, J. Clin. Invest. October 2007
“You cannot mix and match bands from various gels that were run at different times or exposed for different amounts of time….”
“If you are going to splice lanes together (from the same gel) that are noncontiguous, you MUST insert a thin black or white line between the lanes and explicitly mention this in the figure legend…”
Our original figure - different gels clearly separated
“levels” command was applied to entire image - no data are created or removed
“levels” command was applied to green channel only, and only one portion of the image.