ABERRANT FUNCTIONAL CONNECTIVITY OF DL PFC AND CINGULATE NETWORKS IN PATIENTS WITH MDD DURING WORKIN...
Download
1 / 30

By Sharleen Yuan Special Topics-Affective Disorders 10.2.09 - PowerPoint PPT Presentation


  • 77 Views
  • Uploaded on

ABERRANT FUNCTIONAL CONNECTIVITY OF DL PFC AND CINGULATE NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING. By Sharleen Yuan Special Topics-Affective Disorders 10.2.09. Depression affects 5% of the total population. www.cdc.gov/nchs. Depression Symptoms (more than 2 weeks).

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about ' By Sharleen Yuan Special Topics-Affective Disorders 10.2.09' - nardo


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript

ABERRANT FUNCTIONAL CONNECTIVITY OF DL PFC AND CINGULATE NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING

By Sharleen Yuan

Special Topics-Affective Disorders

10.2.09


Depression affects 5 of the total population
Depression affects 5% of the total population NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING

www.cdc.gov/nchs


Depression symptoms more than 2 weeks
Depression Symptoms (more than 2 weeks) NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING

  • Agitation, restlessness, and irritability

  • Dramatic change in appetite, often with weight gain or loss

  • Extreme difficulty concentrating

  • Fatigue and lack of energy

  • Feelings of hopelessness and helplessness

  • Feelings of worthlessness, self-hate, and inappropriate guilt

  • Inactivity and withdrawal from usual activities, a loss of interest or pleasure in activities that were once enjoyed (such as sex)

  • Thoughts of death or suicide

  • Trouble sleeping or excessive sleeping


The hours
“THE HOURS” NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING


Depression research has focused on monoamine transmission
Depression research has focused on monoamine transmission NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING


Different mechanisms and systems are now being examined
Different mechanisms and systems are now being examined NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING

  • Genetics

  • BDNF

  • HPA axis

    • Stress

  • Structural changes

  • Abnormal brain activation

    • DLPFC activation (main focus)


Pfc anatomy and orientation
PFC anatomy and orientation NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING

Image: Caltech/Todd Hare


Acc anatomy and orientation
ACC anatomy and orientation NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING


Pfc what does it do
PFC: What does it do? NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING

  • Weighs consequences of future actions

    • Plans and organizes those action

    • Integration of motor and sensory information

  • Executive functions

    • Planning and regulating behavior

    • Problem solver!


Pfc what else does it do
PFC: What else does it do? NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING

  • Concerned with sequencing of behavior over time

    • ST “working” memory

  • DLPFC: Densely interconnected association regions

    • Projects to numerous cortical and subcortical regions


People with mdd had an increase in left dlpfc activation
People with MDD had an increase in left DLPFC activation NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING

Matsuo, K. et al. (2007). Molecular Psychiatry, Vol 12.


Depression and dlpfc
Depression and DLPFC NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING

  • DLPFC-striatum-thalamus circuit and frontolimbic-subcoritcal circuit

    • Involved in control of cognitive and executive function (DLPFC primary center)

    • Debate b/twn hypoactivity and hyperactivity (more now showing hyperactivity)


Depression and dlpfc1
Depression and DLPFC NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING

  • Hyperactivity of the DLPFC

    • Seen also in schizophrenia

    • Could be due to DA abnormalities

      • DA important in modulating prefrontal activation dur working memory

      • Underlie issue of abnormal function of frontolimbic network in frontolimbic circuit


Depression and dlpfc2
Depression and DLPFC NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING

  • Why is there hyperactivity?

    • Could be a compensatory mechanism  increase WM-related activation is needed

    • But also found abnormalities in the ACC


Depression and acc
Depression and ACC NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING

  • Anterior cingulate cortex

    • Contributes to executive functions

      • Attention, inhibition, cognitive conflicts

    • Key role in emotional expression, affect regulation, and cognitive processing

    • Significant activation in MDD


Depression and acc1
Depression and ACC NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING

  • Activated during low cognitive demand or neutral baseline

  • Is activation due to the cognitive task or reflect an aberrant TID?

  • Functional connectivity and relationship of lateral PFC and ACC not determined


Hypothesis
Hypothesis NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING

  • In MDD patients:

    • Abberant functional connectivity pattern in DLPFC  increased TIA

    • Aberrant functional connectivity pattern in the ACC  decreased TID


Methods
Methods NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING

  • 8 males, 6 females with MDD

    • DSM-IV diagnosed w/o any other Axis I disorder

    • Pts treated w/ AD (different types)

  • Psychopathology rated through the BPRS, the HAMD-21, and the CGI

  • 7 males, 7 females in Control grp


Methods1
Methods NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING


H s g
H S G NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING


H s g1
H NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSINGS G


r NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING


Results
Results NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING


Results1
Results NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING


Results2
Results NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING


Discussion
Discussion NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING

  • Two main findings:

    • 1. connectivity abnormalities in the DLPF/parietal network ( + correlation w the delay period of WM task)

    • 2. connectivity abnormalities in the VLPF/cingulate network


Discussion1
Discussion NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING

  • Increased DLPFC suggests a compensatory recruitment

  • Increasing cognitive demand requires greater recruitment to maintain task performance


Discussion2
Discussion NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING

  • Increased ACC contributes to a failure of deactivation in MDD patients

  • MDD patients with more deactivation of ACC showed greater clinical improvement increased activation cld represent a neg prognostic regarding clinical recovery


EPIC NETWORKS IN PATIENTS WITH MDD DURING WORKING MEMORY PROCESSING


ad