Exercise physiology and Exercise testing. Mitochondrial DNA and Maximun Oxygen Consumption. Index. Introduction about this article General information 1º investigation 2º investigation 3º investigation 4º investigation Author’s opinion Final conclusion.
Mitochondrial DNA and
Maximun Oxygen Consumption
DNA: Deoxyribonucleic acid (DNA) is
a nucleic acid that contains the genetic
instructions used in the development
and functioning of all known
living organisms and some viruses.
The main role of DNA molecules
is the long-term storage of information
Different individual have different DNA sequence.
Morphs may account for some of the
differences including VO2 max.
Dna mitochondrial: (mtDNA)
is the DNA located in
organelles called mitochondria.
Authors: Dionne et al.
Aim: Association between mitochondrial
DNA sequences and aerobic performance.
Also they assessed the relationship of baseline
VO2 max and the response to training.
Process: Endurance-training program
during 20 week.
Subject: 46 North Americans who
Results: The subjects had a morph in the gene
encoding Subunit 5 of
Conclusion: Relationship to the training
responses of VO2 max.
Authors: Rivera and colleagues
Aim: Measure the frequency of each of the
three morph identified within
the NADH dehydrogenase and of one morph of the D-loop.
Subject: 125 elite endurance athletes and 65 sedentary.
Results: Don’t found difference in the
frequency of these morph between groups
Authors:Chen et al, Ma et al.
Aim:A researches focused on the D-loop,
which contains factors that the
modulate mithocondrial DNA replications and transcription.
Subject:A sample of 120 Chinese subjects: 67 elite endurance
athletes, 33 general endurance athletes, and 20 sedentary.
Results: There were nine morphs, and their frequencies
were significantly different between three groups.
Conclusions: This apparent association between mithocondrial
DNA D-loop polymorphism and endurance capacity needs
confirmation. The authors suggested that a better relationship
might exist between the mithocondrial DNA morphs
endurance performance rather than VO2max.
Authors: Melton et al.
Aim: Relationship between mitochondrial DNA D-loop
morphs and VO2max.
Subjects: 40 well-trained Australian male endurance cyclists.
Results: There wasn’t association between VO2max and
the D-loop morphs in this population of athletes.
The autors are in agreement with reports of
Dionne et al. (1991) and Rivera et al. (1998),
who found no significant relationship
between D-loop morphs and either sedentary
VO2max or elite endurance athlete status.
The discrepancy between these findings
and those of Chen et al. (2000) and Ma et al. (2000)
may be related to the ethnic differences
between the subjects and the small sample sizes do
not allow firm conclusions about the presence
or absence of small effects.
There is evidence that V02max in athletes is
limited by the ability to deliver oxygen to the
muscles, rather than the ability of muscles.
However, mithocondrial function
could still be closely related to the
trainability of VO2max in previously
sedentary population and sub-VO2maximal
endurance performance in athletes.
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