Question. Scenario 1. Scenario 2. Make a scenario of an MCQ. Outline the signs and symptoms that you would expect in a patient with hypersecretion of adrenocortical hormones. Give 4 options for the MCQ question.
Make a scenario of an MCQ. Outline the signs and symptoms that you would expect in a patient with hypersecretion of adrenocortical hormones. Give 4 options for the MCQ question.
An obese 50-year old man presents with high blood glucose levels. He shows buffalo torso and moon face and is complaining of purple striae after injury.
The laboratory blood tests show high blood RBC’s and relative polycythemia, hypokalemia and hyponatremia.
He is most probably suffering from:
A 40-year old woman presents to the physician with symptoms of:
The lab results show:
The most appropriate diagnosis is:
Scenario 3 ( M. Halim)
Scenario 4 (Mahnoor)
A woman comes into the clinic and complains to the doctor about her lethargicness. The doctor observes blotches on her face along with hypertrichosis. She complains about being sick more than usual and irregular menstrual cycles. Her blood report showed ↑ glucose levels and hypokalemia was also observed. What do you think this patient is suffering from:
Hyposecretion of ACTH
Hypersecretion of ACTH
A patient was presented to the hospital having high blood pressure. His lab tests show:
Which of the following disorder is he most probably suffering from:
Scenario 5 (Wadia Imtiaz)
Scenario 6 (Khizra)
A person reported to the physician with high blood pressure, muscle weakness, nervousness, lightheadedness, numbness and hair on the face. His lab reports show decrease in K levels, decreased eosinophils and basophils, increased RBC’s and platelet count.
What can be the most likely diagnosis?
Hyposecretion of adrenocortical hormones
Hypersecretion of adrenocortical hormones
A female of about 45 years presents to the hospital with polyuria, dehrdration, sluggishness, muscle wasting and skin pigmentation in blotches. Clinical examination reveals:
What is the appropriate diagnosis:
A patient reports to the doctor of lethargic condition with polyphagia. Upon his vital examination his/her pulse and blood pressure were low. Sexually, he/she has slow/ decreased libido and hyposecretion of sex hormones. Upon his urinary and blood glucose test, following are the values:
which hormone deficiency is possible:
A patient reports to the doctor with edematous appearance of his face apparently moon face with excessive deposition of fats in thoracic and upper abdominal region. His blood pressure is also high. On examination doctor comes to know that the patient has excessive growth of facial hair and acne problems.
Lab reports show that his plasma ACTH & cortisol levels are high. He also has:
What would you suspect that patient will be suffering from:
Dr. Ayisha Qureshi
Conn’s Syndrome is the disorder caused by the hypersecretion of Aldosterone due to primary cause or defect in the zona glomerulosa itself.Primary aldosteronism(conn’s syndrome)
It may occur due to:
It is a disorder caused by the inability of the adrenal cortex to produce the cortical hormones. This is frequently caused by the primary atrophy of the adrenal cortex. The patient presents with mineralocorticoid and glucocorticoid deficiency.Hypoadrenalism- ADDISON’S DISEASE
The causes can be:
Patient cannot maintain normal blood glucose levels as no gluconeogenesis b/w meals. Patient cannot Fast.
Nausea, vomiting, fever, diorrheoaand anemia.
All metabolisms effected leading to fatigue and sluggishness.
Patient highly susceptible to the deteriorating effects of stress.
Even mild infections can lead to death.
Pigmentation of the skin in the form of blotches b/c of increased secretion of ACTH as feedback. These brownish-black areas appear in axilla, genital areas, lips, buccal mucosa.
Hypersecretion by the adrenal cortex causes a complex cascade of hormone effects called Cushing's syndrome. Many of the abnormalities are due to abnormal amounts of cortisol but increased amounts of aldosterone and androgens are also responsible.Hyperadrenalism- Cushing’s Syndrome
- Pituitary adenoma
- Ectopic ACTH syndrome
- Adrenal adenoma
- Adrenal carcinoma
When Cushing’s syndrome is secondary to excess secretion of ACTH by the anterior pituitary, it is called CUSHING’S DISEASE.
The treatment is followed by administration of adrenal steroids to make up for any insufficiency that may arise.
It is a disorder caused by an occasional adrenocortical tumor secreting excessive quantities of androgens that cause intense masculinizing effects throughout the body.Adrenogenital syndrome
Precocious development in boys.
In prepubertal male, a virilizing adrenal tumour causes same characteristics as in the female plus rapid development of the male sex organs.
In adult male, the virilising characteristics are often masked by the virilising effects of Testosterone.
Diagnosis is made by the presence of excess 17-ketosteroids in the urine.