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Lipid Profiles & NSW. LCDR Jim Mucciarone NSWG-2 16 July 2008. Study. Reviewed age, height, weight, total cholesterol, LDL, HDL and Triglycerides in 85 SEAL physicals conducted in CY 2007. Compared results with ATP-III standards for Cholesterol and LDL. Target for cholesterol < 200 mg/dl

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Lipid profiles nsw

Lipid Profiles &NSW

LCDR Jim Mucciarone

NSWG-2

16 July 2008


Study
Study

  • Reviewed age, height, weight, total cholesterol, LDL, HDL and Triglycerides in 85 SEAL physicals conducted in CY 2007.

  • Compared results with ATP-III standards for Cholesterol and LDL.

    • Target for cholesterol < 200 mg/dl

    • Target for LDL < 130 mg/dl


Results
Results

  • Avg Age: 32.83 (21-52)

  • Avg Cholesterol: 186.6 (108-312)

  • Avg LDL: 119.9 (70-221)

  • 22/85 (25.9%) Total Chol > 200

  • 23/85 (27.1%) LDL > 130


Biases
Biases

  • Age

    • 5 years AD, Retirement Physicals included

  • Medications

    • Excluded personnel known to be on meds

  • Fasting

    • Assumed patients fasted appropriately


Significance
Significance

  • Increased serum cholesterol significantly associated with increased risk of death before age 50 (Klag, et al, NEJM, 1993)

  • Men < 39 y/o with serum cholesterol > 200 have increased overall mortality

    • > 240 = 2.10 to 3.63 RR of CHD or CVD death

  • Men < 39 y/o with chol < 200 = 3.8 to 8.7 years of life (Stamler, et al, JAMA, 2000)

  • “Grow the Force”


Treatment
Treatment

  • Therapeutic Lifestyle Changes

    • Reduce Sat Fats/Cholesterol

    • Reduce Body Weight

    • Increase stanols/sterols and fiber

    • Increase physical activity

  • Prefer to avoid statins

    • Lifelong medication

    • Assoc with muscle pain


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