MSc Medical Biochemistry,
They differ form each other in a number of the following properties.
Amino sugar – D-Glucosamine or D-Galactosamine.
Uronic acid – D-Glucuronic acid or L-Iduronic acid.
1. Chondroitin sulfate
Widely distributed in bone, cartilage & tendons.
In cartilage, it binds collagen & hold fibers in a tight strong network.
Role in Compressibility of cartilage in weight bearing along with Hyaluronic acid.
2 types of chondroitin sulfate :
Sulphated at C 4 or C 6 group.
Same as heparin except some amino groups carry acetyl group & % of Sulphate groups are smaller.
It is extracellular GAG .
Present in basement membrane & as a ubiquitous component of cell surface.