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IL-23. IL-12. p35. p19. p40. p40. Interleukin (IL)-12 and IL-23 are heterodimeric cytokines, composed of a common IL-12/23p40 subunit and a unique subunit, IL-12p35 and IL-23p19 respectively. Il-12 and IL-23 are involved in the regulation of T cell immune responses.

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p19

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P19

IL-23

IL-12

p35

p19

p40

p40

Interleukin (IL)-12 and IL-23 are heterodimeric cytokines,

composed of a common IL-12/23p40 subunit and a unique subunit, IL-12p35 and IL-23p19 respectively.

Il-12 and IL-23 are involved in the regulation of T cell immune responses.


P19

IL-12 and IL-23 signal through heterodimeric receptor complexes.

The Il-12 receptor complex is composed of IL-12Rβ1 and IL-12Rβ2 subunits.

The IL-23 receptor complex is composed of IL-12Rβ1 and IL-23R subunits.

IL-12 and IL-23 receptors are expressed on myeloid cells, such as T cells,

as well as endothelial cells

p19

p40

p40

p35

IL-23 Receptor

Complex

IL-12 Receptor

Complex

IL23R

IL12Rβ1

IL12Rβ2

IL12Rβ1

T cells, Natural Killer cells,

Dendritic cells

T cells, Natural Killer cells,

Dendritic cells


P19

When Il-12 and IL-23 bind receptors on naive CD4+ T cells, they cause

these cells to differentiate into T helper (Th) cells, Th1 and Th17 respectively,

which can then mediate an appropriate immune response by secreting

particular pro-inflammatory cytokines.

p19

p40

p40

p35

IL23R

IL12Rβ1

IL12Rβ2

IL12Rβ1

Th17

Naive T cell

Naive T cell

Th1


P19

Th17

Th1

IL-17A

IFNγ

IFNγ

IL-17F

IL-22

IFNγ

Cell-mediated immunity against

intracellular bacteria and viruses

Cell-mediated immunity against

extracellular bacteria and fungi


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