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p19

IL-23. IL-12. p35. p19. p40. p40. Interleukin (IL)-12 and IL-23 are heterodimeric cytokines, composed of a common IL-12/23p40 subunit and a unique subunit, IL-12p35 and IL-23p19 respectively. Il-12 and IL-23 are involved in the regulation of T cell immune responses.

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p19

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  1. IL-23 IL-12 p35 p19 p40 p40 Interleukin (IL)-12 and IL-23 are heterodimeric cytokines, composed of a common IL-12/23p40 subunit and a unique subunit, IL-12p35 and IL-23p19 respectively. Il-12 and IL-23 are involved in the regulation of T cell immune responses.

  2. IL-12 and IL-23 signal through heterodimeric receptor complexes. The Il-12 receptor complex is composed of IL-12Rβ1 and IL-12Rβ2 subunits. The IL-23 receptor complex is composed of IL-12Rβ1 and IL-23R subunits. IL-12 and IL-23 receptors are expressed on myeloid cells, such as T cells, as well as endothelial cells p19 p40 p40 p35 IL-23 Receptor Complex IL-12 Receptor Complex IL23R IL12Rβ1 IL12Rβ2 IL12Rβ1 T cells, Natural Killer cells, Dendritic cells T cells, Natural Killer cells, Dendritic cells

  3. When Il-12 and IL-23 bind receptors on naive CD4+ T cells, they cause these cells to differentiate into T helper (Th) cells, Th1 and Th17 respectively, which can then mediate an appropriate immune response by secreting particular pro-inflammatory cytokines. p19 p40 p40 p35 IL23R IL12Rβ1 IL12Rβ2 IL12Rβ1 Th17 Naive T cell Naive T cell Th1

  4. Th17 Th1 IL-17A IFNγ IFNγ IL-17F IL-22 IFNγ Cell-mediated immunity against intracellular bacteria and viruses Cell-mediated immunity against extracellular bacteria and fungi

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