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The Institute of Human Virology Growing the IHV to Impact the World. •. Dave Wilkins RAC Sept 09, 2004. I. The Basis for the Need to Act. With 42 million infected worldwide, HIV/AIDS is the worst epidemic in the history of the world – and it is going to get much worse

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The Institute of Human Virology

Growing the IHV to

Impact the World

Dave Wilkins

RAC Sept 09, 2004


I the basis for the need to act
I. The Basis for the Need to Act

  • With 42 million infected worldwide, HIV/AIDS is the worst epidemic in the history of the world – and it is going to get much worse

  • 29 million Africans are infected with HIV, and that number will rise significantly in the near future

  • In many locations in Africa, one third of babies are infected before their 1st birthday through mother to child transmission

  • HIV / AIDS crises are developing in countries such as China & India – the pandemic has become a massive global issue

  • Inner city dwellers in many US cities also suffer major ratios of infection, especially in African-American populations.

40-50 million infected, 20-30 million dead, 0 cured


I the basis for the need to act1
I. The Basis for the Need to Act

In Baltimore

  • AIDS is the 2nd largest killer of African Americans between the ages of 25 & 50

  • Baltimore has the 2nd highest sero-prevalence rate in America

  • In our 9 clinic sites, the IHV is serving over 4000 patients


I the basis for the need to act2
I. The Basis for the Need to Act

From an American’s Perspective

Africa’s 29M infected are the equivalent of the entire populations of Ohio, Maryland and Florida

If current projections hold, in 10 years, Africa’s newly infected will include the equivalent the entire populations of Nebraska, North Carolina, Maine, Minnesota, Vermont, Nevada, Montana, Oregon, New Mexico, Mississippi, Kansas and Missouri


Ii uniquely positioned to impact the disease
II. Uniquely Positioned to Impact the Disease

The IHV: Our Team

  • Founded anddirected by Robert C. Gallo, M.D:

    • Co-discoverer of the HIV virus that is the cause of AIDS

    • Most referenced scientist in the world for the decade of the 1980’s

    • 6th most referenced scientist in the world currently

    • World Expert on basic research of the HIV virus and its mechanisms

    • Recently inducted into the National Inventors’ Hall of Fame (notable inductees below; )

George Washington Carver Thomas Edison Alexander Graham Bell Robert Gallo

  • Dr. Robert Redfield:

  • Largest Health Care Grant in UM History: $65M

  • UMB School of Medicine’s Researcher of the Year

  • Dr. William Blattner:

  • Leading largest HIV/AIDS program in the largest country (Nigeria) on the most affected Continent (Africa)

  • Recently won $54M grant to continue this work


Ii uniquely positioned to impact the disease1
II. Uniquely Positioned to Impact the Disease

The IHV: Our Work

Basic

Research

Vaccine

Development

Animal

Models

Clinical

Research

Epidemiology

& Prevention

Vaccine

Development

Global Impact

Local Presence

  • Leading global HIV/AIDS Basic Research under Dr. Gallo’s scientific leadership

  • Developing one of the world’s most promising HIV vaccine candidate

  • Received $130M (largest healthcare grants in UM history) in Pres. Bush’s PEPFAR Initiative

  • Operating Maryland’s largest African American AIDS clinic

  • Received 8 patents on IHV developed technologies in the past year

  • Established a spinoff company to commercialize technologies and support MD’s economy


Ii uniquely positioned to impact the disease2
II. Uniquely Positioned to Impact the Disease

8 Years of Dramatic Growth in Sponsored Research Funding


II. Uniquely Positioned to Impact the Disease

International Programs

Programs in 108 sites in 36 countries


Ii uniquely positioned to impact the disease3
II. Uniquely Positioned to Impact the Disease

China

  • 8 months of development work

  • Lecture in April in Xian by George Lewis

  • 3 Day retreat with key members of China CDC

  • Tangible Program defined

  • June trip by Dr.’s Redfield and Gilliam to train all of China’s AIDS doctors,

  • August, September and November Trips for Dr. Gallo to sign broad MOU’s

  • Funding Sources: NIH, China CDC, Gates & Clinton Foundations, WHO


Corporate development cca gbc
Corporate Development: CCA, GBC

  • Corporate Council on Africa

  • 100+ Member Companies making up 85 % of investment in Africa

  • Economic Summit Meeting: Baltimore, June 2005

  • Shell Oil: DC, Nigeria, Hospitals, Programs

  • Next: IHV programs with Exxon/Mobile, Chevron/Texaco, 3M

  • Global Business Coalition on AIDS

  • Led by Richard Holbrooke, former UN Ambassador

  • 100+ member companies

  • Worldwide focus (China)

  • Upcoming Meeting w/ Dr. Gallo


Iii the vision what would it take
III. The Vision: What Would It Take?

  • As demonstrated by recent scientific progress and grant wins, the IHV has given the System and the State stellar investment returns.

    • The IHV received $4.4M in State funding in FY 04, and won $130M in grants. This represents a 29:1 return on investment (ROI).

    • Since IHV’s inception, our ROI on state funds is 10:1.

    • The IHV is impacting Baltimore and the world uniquely

  • However, we are just scratching the surface of what can be accomplished. IHV can impact the world on an even greater basis in the future.


Iii the vision what could be achieved
III. The Vision: What Could be Achieved

Example

The IHV has consistently demonstrated a 10+:1 return on investment on state dollars.

What would happen if the state invested an additional $2-3M in IHV vaccine research, towards obtaining some of the $533M of 2005 Vaccine Research funding?

If our ROI holds, these funds could result in a significant return to the state, and system.


Vi summary
VI. Summary

Additional Perspective

The IHV is uniquely positioned towards

solving mankind’s greatest problem…

…while serving patients and doing cutting edge

science within the University of Maryland.


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