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LETTURA A TEMA Fibrillazione Atriale: Stato dell’Arte Prof. Luigi Padeletti - PowerPoint PPT Presentation


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LETTURA A TEMA Fibrillazione Atriale: Stato dell’Arte Prof. Luigi Padeletti. Presenta: Saverio Iacopino. Sant ’ Anna Hospital Catanzaro. Network for person: Padeletti, Luigi. Network for person: Padeletti, Luigi. HF and AF are “ emerging epidemics ”.

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LETTURA A TEMA

Fibrillazione Atriale: Stato dell’Arte

Prof. Luigi Padeletti

Presenta: Saverio Iacopino

Sant’Anna Hospital Catanzaro




Hf and af are emerging epidemics
HF and AF are “emerging epidemics”


The interaction between AF and HF means thatneither can be treated optimally without treating both

promotes

HF

AF

aggravates


  • Ventricular resynchronization and

  • atrial pacing (algorithms, atrial

  • resynchronization) may be considered

  • a major revolution in treating AF and

  • HF by electrical stimulation


Primary outcome:

device-classified AT/AF frequency

Secondary outcomes:

device-classified AT/AF burden

and PAC frequency

Padeletti et al. JCE. 2003


Long-term Reduction of AT Recurrences in Patients Paced for BT-SND

In a long-term observation on BT-SND patients, a significant decrease of AT related hospitalizations and increase of mean AT cycle length were measured. These data suggest that rhythm control therapies may induce an inversion of AT progression.

Padeletti et al. HR. 2005


MASCOT Trial BT-SND

  • Multicenter, single-blind, randomized, parallel study evaluating

    the safety and efficacy of a specific AOP algorithm (AF

    Suppression™, St Jude Medical, Sylmar, CA) in CRT patients.

  • After successful CRT device implantation, and before hospital

    discharge, the patients were randomly assigned to AOP ON

    versus OFF for the duration of follow-up.

Padeletti et al. AHJ. 2008


MASCOT Trial: Incidence of Permanent AF BT-SND

Padeletti et al. AHJ. 2008


MASCOT Trial: Mortality BT-SND

Padeletti et al. AHJ. 2008


The two options to treat AF are either rhythm control defined as the strategy to restore and maintain sinus rhythm or rate control defined as the strategy to maintain the patient in AF and avoid too fast and too slow ventricular rates…..

Padeletti L. et al. EHJ 2007


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