Folate Augmentation of Treatment – Evaluation for Depression: a randomised controlled trial . NWORTH open day, May 2012 Yvonne Sylvestre & Richard Tranter. HTA Project 04/35/08 ISRCTN37558856. Background . Depression
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Folate Augmentation of Treatment – Evaluation for Depression: a randomised controlled trial
NWORTH open day, May 2012
Yvonne Sylvestre& Richard Tranter
HTA Project 04/35/08 ISRCTN37558856
Folate status in patients with depression
Folate & antidepressant response
To evaluate whether:
and is supported by …
Screening Interview (Visit 1 week -2)
Randomisation (Visit 2 week 0)
Randomisation (Folic acid/placebo)
First follow up (Visit 3 week 4)
Second follow up (Visit 4 week 12)
Third follow up (Visit 5 month 6)
Metabolism of folate and homocysteine
Carr DF, et al. 2009. Pharmacogenomics J. Oct;9(5):291-305.
Aged between 19 and 81 years (mean 45)
Bangor (51%), Wrexham (25%), Swansea (24%)
28% in full time work
28% part time work, students or retired
43% unemployed, at home or sick
23% single, 21% previously had partner,
55% currently had a partner or spouse
Watch this space …………………………….
The Folated team thanks you for listening.