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班級 : 幼三乙 組員 : 王文欣 4a0i0034 吳珮瑜 4a0i0070 指導老師 : 陳韻如 PowerPoint PPT Presentation


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化學治療中 不可或缺的角色 — 止吐劑. 班級 : 幼三乙 組員 : 王文欣 4a0i0034 吳珮瑜 4a0i0070 指導老師 : 陳韻如. 摘要. 化學治療的過程中最常出現的副作用首推噁心、嘔吐,不但影響癌症病人對於治療的順從性,也干擾病人日常生活作息。止吐劑的給予在化學治療中扮演了一個很重要的角色,它對支持癌症病人完成化學治療的周期有其舉足輕重的必要性。. 前言.

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班級 : 幼三乙 組員 : 王文欣 4a0i0034 吳珮瑜 4a0i0070 指導老師 : 陳韻如

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: 4a0i0034

4a0i0070

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() (CINV)



1953(serotonin)DopamineHistamineAcetylcholineP substance PChemoreceptor trigger zoneCTZArea Postrema


(Serotonin)5-Hydroxy tryptamine5HT5-HT3CTZNucleus TractusSolitariussubstance PNeurokinin-1NK-1CTZ


  • CTZ(neurotransmitters) (vomiting center)


serotonin (5-hydroxy tryptamine 5-HT) 5-HT3 CTZ


(serotonin receptors) substance P neurokinin-1 (NK-1) CTZ substance P NK-1


  • (

    )

  • (Vestibular mechanisms) ()


CINV

(Acute emesis)

1~21~6 24

(Delayed emesis)

24

(Anticipatory emesis)


3 (corticosteroids) (type three 5-hydroxytryptamine, 5-HT3 receptor antagonists) (neurokinin-1, NK-1 receptor antagonists)


Corticosteroids

Corticosteroids Corticosteroids 5-HT3 receptor antagonists (aprepitant) corticosteroids dexamethasone


Corticosteroids

  • Corticosteroids


dexamethasone

  • dexamethasone


NK-1 receptor antagonists

NK-1 receptor antagonists

aprepitant5-HT3receptorantagonists corticosteroids aprepitant5-HT3 receptor antagonists corticosteroids


5-HT3 receptor antagonists

serotonin serotonin 5-HT3

5-HT3 receptor antagonists palonosetron30~100 (40)


ASCO (American Society of Clinical Oncology)


()


(cisplatin)

30-60(Emend)([Novaben][Kytril])([dexamethasone])


(doxorubicin)

30-60([Novaben][Kytril][Aloxi)([dexamethasone])


(paclitaxel)

30-60(vincristine)


Primperan

: MetoclopramideHCl( 5mg)

:

:P5

:

Bropin

Prochlorperazine(5mg)

:

:


Novamin

Prochlorperazine(5mg)

:

:095

Nidolium

Domperidone (10mg) /tab

:

:SP1



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