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Pathogenic Enteric Bacteria I. Dr A. Aziz Djamal MSc.DTM&H.SpMK (K). Topics Escherichia . Vibrio Klebsiella Proteus Enterobacter. Escherichia Klebsiella Proteus Enterobacter All are member of Enterobacteriaceae family Rod shape Gram negative Facultative anaerob.

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Pathogenic Enteric Bacteria I

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Pathogenic enteric bacteria i

Pathogenic Enteric Bacteria I

Dr A. Aziz DjamalMSc.DTM&H.SpMK(K)


Topics escherichia vibrio klebsiella proteus enterobacter

Topics

Escherichia .

Vibrio

Klebsiella

Proteus

Enterobacter


Pathogenic enteric bacteria i

Escherichia

Klebsiella

Proteus

Enterobacter

All are member of Enterobacteriaceaefamily

Rod shape

Gram negative

Facultative anaerob


Pathogenic enteric bacteria i

Genus Vibrio belong to the family of Vibrionaceae

Curve rod shape

Gram negative

Facultative anaerob

One single polar flagel


Escherichia coli

Escherichia coli

Found by Theodor Escherich ( Austrian ) 1882

Bacteria coli commune

Normal inhabitant of intestinal human and warm blooded animal

By the time proceed it is also in process of adaptation and change


Pathogenic enteric bacteria i

It is used as standard for fecal contamination.

Water quality for household purpose.

MPN test / Index.

Lactose fermenter


Pathogenic strains

Pathogenic strains

EPEC ( Enteropathogenic )

ETEC ( Enterotoxigenic )

EIEC ( Enteroinvasive )

EHEC( Enterohaemorrhagic )

EAEC ( Enteroadherent )


Enteropathogenic e coli

Enteropathogenic E coli

Infantile diarrhea

Attachment to immature intestinal mucosal cells

Destruction of mucosal villi

Causing diarrhea followed by fever and icteric

Fatal infection especially on neglected labor.


Enterotoxigenic e coli etec

Enterotoxigenic E. coli (ETEC)

Produced Enterotoxin.

Plasmid mediated enterotoxin production.

There are 2 kind of Toxins : Lt ( Labile toxin )

St ( Stable toxin)


Lt labile toxin

Lt ( Labile toxin )

Big Molecule.

Antigenic.

Cross reaction with Cholera toxin.

Activate Adenylatecyclase enzyme -- Cascade reaction-end product cyclic -5--AMP ( Adenosine Mono Phosphate )--Profuse watery diarrhea.

Dehydration--Electrolyte and Acid-Base derangement—metabolic acidosis –renal failure –death.


Stable toxin st

Stable toxin (St)

Smaller molecule

Non Antigenic.

Activate Guadenylatecyclase enzyme system—cascade reaction—end product cyclic –5– GMP (Guadenosin Mono Phosphate ) –Low quality energy resouces– mild diarrhea.


Enteroinvasive escherichia coli eiec

Enteroinvasive Escherichia coli (EIEC)

Site of infection mucosal cells layer of Colon.

Shigella like infection.

Shiga like toxin – toxic to colonic mucosal cells- necrosis—ulcers—bleeding ( Blooded diarrhea), fever – tenesmusani ( TriasBacillar Dysentery)


Enterohemorrrhagic e coli ehec

Enterohemorrrhagic E coliEHEC

Firstly dairy product contamination, meat on refrigerator—Produce toxin ( Shiga like toxin )—strain O157 H7—Fever, diarrhea, abdominal cramp-Hemolytic uremic syndrome.

Newly strain O104 H4, outbreak in German ,May 31 found 470 cases with HUS---9 deaths. Raw lettuce, cucumber and tomatoes.


Enteroadherent e coli

Enteroadherent E coli

Multilayer colonization on intestinal mucose.

Biofilm formation

Inhibit water and nutrition absorbtion.

Malabsorbtion syndrome.


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