Pathogenic Enteric Bacteria I. Dr A. Aziz Djamal MSc.DTM&H.SpMK (K). Topics Escherichia . Vibrio Klebsiella Proteus Enterobacter. Escherichia Klebsiella Proteus Enterobacter All are member of Enterobacteriaceae family Rod shape Gram negative Facultative anaerob.
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Pathogenic Enteric Bacteria I
Dr A. Aziz DjamalMSc.DTM&H.SpMK(K)
All are member of Enterobacteriaceaefamily
Genus Vibrio belong to the family of Vibrionaceae
Curve rod shape
One single polar flagel
Found by Theodor Escherich ( Austrian ) 1882
Bacteria coli commune
Normal inhabitant of intestinal human and warm blooded animal
By the time proceed it is also in process of adaptation and change
It is used as standard for fecal contamination.
Water quality for household purpose.
MPN test / Index.
EPEC ( Enteropathogenic )
ETEC ( Enterotoxigenic )
EIEC ( Enteroinvasive )
EHEC( Enterohaemorrhagic )
EAEC ( Enteroadherent )
Enteropathogenic E coli
Attachment to immature intestinal mucosal cells
Destruction of mucosal villi
Causing diarrhea followed by fever and icteric
Fatal infection especially on neglected labor.
Enterotoxigenic E. coli (ETEC)
Plasmid mediated enterotoxin production.
There are 2 kind of Toxins : Lt ( Labile toxin )
St ( Stable toxin)
Lt ( Labile toxin )
Cross reaction with Cholera toxin.
Activate Adenylatecyclase enzyme -- Cascade reaction-end product cyclic -5--AMP ( Adenosine Mono Phosphate )--Profuse watery diarrhea.
Dehydration--Electrolyte and Acid-Base derangement—metabolic acidosis –renal failure –death.
Stable toxin (St)
Activate Guadenylatecyclase enzyme system—cascade reaction—end product cyclic –5– GMP (Guadenosin Mono Phosphate ) –Low quality energy resouces– mild diarrhea.
Enteroinvasive Escherichia coli (EIEC)
Site of infection mucosal cells layer of Colon.
Shigella like infection.
Shiga like toxin – toxic to colonic mucosal cells- necrosis—ulcers—bleeding ( Blooded diarrhea), fever – tenesmusani ( TriasBacillar Dysentery)
Enterohemorrrhagic E coliEHEC
Firstly dairy product contamination, meat on refrigerator—Produce toxin ( Shiga like toxin )—strain O157 H7—Fever, diarrhea, abdominal cramp-Hemolytic uremic syndrome.
Newly strain O104 H4, outbreak in German ,May 31 found 470 cases with HUS---9 deaths. Raw lettuce, cucumber and tomatoes.
Enteroadherent E coli
Multilayer colonization on intestinal mucose.
Inhibit water and nutrition absorbtion.