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Pathogenic Enteric Bacteria I. Dr A. Aziz Djamal MSc.DTM&H.SpMK (K). Topics Escherichia . Vibrio Klebsiella Proteus Enterobacter. Escherichia Klebsiella Proteus Enterobacter All are member of Enterobacteriaceae family Rod shape Gram negative Facultative anaerob.

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Pathogenic enteric bacteria i

Pathogenic Enteric Bacteria I

Dr A. Aziz DjamalMSc.DTM&H.SpMK(K)


Topics escherichia vibrio klebsiella proteus enterobacter

Topics

Escherichia .

Vibrio

Klebsiella

Proteus

Enterobacter


Escherichia

Klebsiella

Proteus

Enterobacter

All are member of Enterobacteriaceaefamily

Rod shape

Gram negative

Facultative anaerob


Genus Vibrio belong to the family of Vibrionaceae

Curve rod shape

Gram negative

Facultative anaerob

One single polar flagel


Escherichia coli

Escherichia coli

Found by Theodor Escherich ( Austrian ) 1882

Bacteria coli commune

Normal inhabitant of intestinal human and warm blooded animal

By the time proceed it is also in process of adaptation and change


It is used as standard for fecal contamination.

Water quality for household purpose.

MPN test / Index.

Lactose fermenter


Pathogenic strains

Pathogenic strains

EPEC ( Enteropathogenic )

ETEC ( Enterotoxigenic )

EIEC ( Enteroinvasive )

EHEC( Enterohaemorrhagic )

EAEC ( Enteroadherent )


Enteropathogenic e coli

Enteropathogenic E coli

Infantile diarrhea

Attachment to immature intestinal mucosal cells

Destruction of mucosal villi

Causing diarrhea followed by fever and icteric

Fatal infection especially on neglected labor.


Enterotoxigenic e coli etec

Enterotoxigenic E. coli (ETEC)

Produced Enterotoxin.

Plasmid mediated enterotoxin production.

There are 2 kind of Toxins : Lt ( Labile toxin )

St ( Stable toxin)


Lt labile toxin

Lt ( Labile toxin )

Big Molecule.

Antigenic.

Cross reaction with Cholera toxin.

Activate Adenylatecyclase enzyme -- Cascade reaction-end product cyclic -5--AMP ( Adenosine Mono Phosphate )--Profuse watery diarrhea.

Dehydration--Electrolyte and Acid-Base derangement—metabolic acidosis –renal failure –death.


Stable toxin st

Stable toxin (St)

Smaller molecule

Non Antigenic.

Activate Guadenylatecyclase enzyme system—cascade reaction—end product cyclic –5– GMP (Guadenosin Mono Phosphate ) –Low quality energy resouces– mild diarrhea.


Enteroinvasive escherichia coli eiec

Enteroinvasive Escherichia coli (EIEC)

Site of infection mucosal cells layer of Colon.

Shigella like infection.

Shiga like toxin – toxic to colonic mucosal cells- necrosis—ulcers—bleeding ( Blooded diarrhea), fever – tenesmusani ( TriasBacillar Dysentery)


Enterohemorrrhagic e coli ehec

Enterohemorrrhagic E coliEHEC

Firstly dairy product contamination, meat on refrigerator—Produce toxin ( Shiga like toxin )—strain O157 H7—Fever, diarrhea, abdominal cramp-Hemolytic uremic syndrome.

Newly strain O104 H4, outbreak in German ,May 31 found 470 cases with HUS---9 deaths. Raw lettuce, cucumber and tomatoes.


Enteroadherent e coli

Enteroadherent E coli

Multilayer colonization on intestinal mucose.

Biofilm formation

Inhibit water and nutrition absorbtion.

Malabsorbtion syndrome.


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