A Novel Dermoscopic Probe for Determining Elasticity Measurements of the Skin

1. A Novel Dermoscopic Probe for Determining Elasticity Measurements of the Skin Group 7: Erica Bozeman Markesha Cook Stephanie Cruz January 24, 2007

2. Design Objective "Structural alterations within cancerous skin-lesions cause unexpected patterns of anatomical deformation in response to mechanical forces." Dr. Michael Miga Hypothesis: If structural alterations in skin cancer lesions differs from that of normal skin when a mechanical force is applied, then a systematic method of measuring the force response of a skin lesion can be compared to that of normal skin to determine the presence of skin cancer. Conduct phantom experiments Design skin-friendly stretching apparatus Develop systematic method of testing skin forces

3. Skin Cancer Types of skin cancer Basal Cell carcinoma Squamous cell carcinoma Melanoma Facts and Statistics Over 1 million new cases of skin cancer diagnosed in US (2006) 1 American dies of melanoma every 67 minutes Treating melanoma costs about $740 million each year World Health Organization 60,000 deaths worldwide/yr 48,000 melanoma; 12,000 other http://www.aad.org/aad/Newsroom/2005+Skin+Cancer+Fact+Sheet.htm http://images.main.uab.edu/healthsys/ep_0137.jpg

4. Current Methods of Detection Clinical eye Accuracy varies with experience Biopsy Dermoscopy 10X magnification, liquid polarizing lens Only ~75-80% accurate Serial photography Software expensive (~30,000) Slow Specialty clinics In vivo confocal microscopy Experimental http://www.jfponline.com/images/5206/5206JFP_AppliedEvidence-fig4.jpg

5. Dermatologist Recommendations Dr. Darrel Ellis Faster More accurate Less expensive Ideal device Small enough to carry in pocket and use with one hand

6. Our Proposed Device Safe Easy Non-invasive Quick Effective Cost-efficient

7. Initial Design: Sony XCD-X710CR camera Force Sensor Mild Skin adhesive

8. Potential Design

9. 25.4 mm 130 mm Sony XCD-X710CR camera Force Sensor FOV: 32mm SKIN Mild Skin adhesive

10. Design Specifications:Ultra-Low Profile Load Cell - S215 • Strain Gauge Technology • Mechanical motion  electronic signal • Measures up to 8 N (2 lb-force) • Dimensions: • 27.94 x 5.99 mm (1.1 x .236 in) • Rigidly mounted on platform beam • Cost:$155

11. Using the PDE Toolbox: Assessing the Expected Outputs of our Device

12. Step 1:

13. Step 2: Melanoma Е ≈ 52 kPa ν ≈ 0.485 Normal Skin Е ≈ 10 kPa ν ≈ 0.485

14. Colormap of Stress in the X-direction σx= Force/ Area σx ≈ 18 kPa Area=0.01m x .02m Force ≈ 3.6 N

15. Now Let’s Compare the Geometric Shapes: Crescent Cube Rectangular

16. Budget • Force Sensor • $155.00 • Probe Materials • $50 • 3M Micropore Surgical tape • $10.00

17. Important Design Dates • End of January • Finalize Device Design • Mid February • Independent Testing Completed • End of February • Device Built • Mid March • Comparative analysis using Dr. Miga’s model • April • Finalize results; prepare for design presentation

18. References • www.skincancer.org • http://www.eurekalert.org/pub_releases/2006-10/osoa-ltt101606.php • http://www.smdsensors.com/detail_pgs/s100.htm • http://www.omega.com/literature/transactions/volume3/strain.html • M. I. Miga, M. P. Rothney, J. J. Ou, "Modality independent elastography (MIE): Potential applications in dermoscopy", Medical Physics, vol. 32, no. 5, pp. 1308-1320, 2005. • Tsap, Leonid V. et al. Efficient Nonlinear Finite Element Modeling of Nonrigid Objects via Optimization of Mesh Models. Computer Vision and Image Understanding. Vol 69, No. 3 March 1998 pp. 330-350. • Wan Abas, W.A.B and J.C. Barbenal. Uniaxial Tension Test of Human Skin In Vivo. J. Biomed. Engng. Vol 4 January 1982 pp.65-71.

19. Questions