INHALATION ANESTHETICS. Prof. Ayman Hussein Kahla Prof. of Anesthesia Technology Public Health & Health Informatics Faculty UMM ALQURA UNIVERSITY. Anesthesia.
Prof. Ayman Hussein Kahla
Prof. of Anesthesia Technology
Public Health & Health Informatics Faculty
UMM ALQURA UNIVERSITY
- interfering with release of neurotransmitters from pre-synaptic nerve terminal (enhance or depress excitatory or inhibitory transmission).
- altering re-uptake of neurotransmitters,
- Changing the binding of neurotransmitters to the post-synaptic receptor sites or
- Influencing the ionic conductance change that follows activation of the post-synaptic receptor by neurotransmitters.
F – C – C* – Br
F F F
Cl – C* – C – O – C – H
H F F
F F H H
F C O C F
F C H
F H F
F – C – C* – O – C – H
F F F
F H F
F– C – C* – O – C – H
F Cl F
- Aliflurane - Chloroform
- Cyclopropane - Diethyl ether
- Enflurane - Ethylene
- Halothane - Methoxyflurane
- Methoxypropane - Roflurane
- Teflurane - Trichloroethylene
- Vinyl ether
“Triad of General Anesthesia”
behavior – dangerous state
- Decrease in systemic blood pressure – myocardial depression and direct vasodilatation.
- Blunting of baroreceptor control and decreased central sympathetic tone.
The main target of inhalation anesthetics is the brain. induction of anesthesia.
(blood : gas partition co-efficient)
Agents with low solubility in blood quickly saturate the blood. The additional anesthetic molecules are then readily transferred to the brain.
BLOOD GAS PARTITION COEFFICIENT
OIL GAS PARTITION CO-EFFICIENT and recovery
Higher the Oil: Gas Partition Co-efficient lower the MAC . E.g., Halothane
MV = Respiratory Rate × Tidal volume
Concentration effect states that with higher inspired concentrations of an anesthetic, the rate of rise in arterial tension is greater.
The ability of the large volume uptake of one gas (first gas) to accelerate the rate of rise of the alveolar partial pressure of a concurrently administered companion gas (second gas).
Usually refers to nitrous oxide combined with an inhalational agent. Because nitrous oxide is not soluble in blood, its' rapid absorption from alveoli causes an abrupt rise in the alveolar concentration of the other inhalational anesthetic agent.