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SITOKIN. Sekresi protein yang menjembatani dan mengatur sistem imun, inflamasi dan hematopoiesis Sitokin diproduksi sebagai respon stimulus dari proses imunitas Sitokin biasanya bekerja dalam waktu yang singkat, jarak antar sel yg dekat, dan dalam jumlah (konsentrasi) yang sangat kecil

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Sitokin

SITOKIN

Sekresi protein yang menjembatani dan mengatur sistem imun, inflamasi dan hematopoiesis

Sitokin diproduksi sebagai respon stimulus dari proses imunitas

Sitokin biasanya bekerja dalam waktu yang singkat, jarak antar sel yg dekat, dan dalam jumlah (konsentrasi) yang sangat kecil

Sitokin bekerja dengan melekat pada membran reseptor yg spesifik, kemudian memberi signal pd sel melalui messenger kedua (sering terjadi enzim tyrosinkinase merusak kejadian tersebut)


Sekresi sitokin oleh
Sekresi sitokin oleh:

  • Limfosit limfokin

  • Monosit monokin

  • Sitosin yg aktif dlm khemotaktik khemokin

  • Sebagai media antar leukosit interleukin(IL)

Reseptor sitokin


Sitokin1
Sitokin

  • Tidak seperti hormon yg tersimpan dalam kelenjar(dlm btk molekul), sitokin cepat disintesis dan disekresikan oleh sel yg berbeda setelah ada stimulus

Sitokin


Aktivitas sitokin
Aktivitas sitokin

  • Berefek thdp sel yg mensekresinya sendiri autokrin

  • Berefek thdp sel didekatnya parakrin

  • Berefek pada sel yg sama tp berjauhan endokrin

  • Produser sitokin paling banyak adalah: sel –Th dan makrofag


Efek sitokin
Efek sitokin

  • Pleiotropism

  • Redunden

  • Sinergik

  • Antagonis

  • Membentuk network sitokin


Pleiotropism
Pleiotropism

  • Kemampuan satu sitokin untuk dapat menyebabkan multiplikasi dari tipe sel target


Redunden
Redunden

  • Multipel sitokin mempunyai efek yg sama atau overlaping


Sinergik
Sinergik

  • Dua atau lebih sitokin mempunyai efek saling menguatkan


Antagonisme
Antagonisme

  • Kemampuan satu sitokin untuk menghambat aksi sitokin lainnya


Klasifikasi sitokin
Klasifikasi sitokin

  • Interleukin, IL

  • Interferon , IFN

  • Tumor necrosis factor, TNF

  • Colony stimulating factor, CSF

  • Chemokine

  • Transforming growth factor


Interleukin il
. Interleukin (IL)

  • Sitokin yg disekresi oleh leukosit yg mampu memberi tanda /menjembatani aktivitas leukosit lainnya

  • IL-1~IL-29


Interferon ifn
. Interferon (IFN)

A group of glycoproteins that produced by human or animal cells following the infection of virus and exposure to various inducing agents


Comparison of ifn ifn ifn
Comparison of IFN-, IFN-, IFN-

_____________________________________

Types Produced cells Main functions

____________________________________

IFN- leukocyte anti-virus,immune regulation

IFN- fibroblast anti-tumor

IFN---Type II Th1,NK ------- weaker anti-virus effect

stronger immune regulation effect

anti-tumor

_____________________________________

Type I


Tumor necrosis factor tnf
.Tumor necrosis factor (TNF)

TNFs were originally thought of as selective antitumour agents, but are now known to have a multiplicity of actions.

  • TNF- is produced mainly by LPS activated monocytes and macrophages.

  • TNF-(lymphotoxin, LT) is produced mainly by activated Th0 and Th1.


Colony stimulating factors csf
. Colony-stimulating factors (CSF)

Cytokines that stimulate proliferation or differentiation of pluripotent hematopoietic stem cell and different progenitors.

  • Multi-CSF (IL-3)

  • Granulocyte macrophage-CSF(GM-CSF)

  • Monocyte-CSF(M-CSF)

  • Granulocyte-CSF(G-CSF)

  • Stem cell factor(SCF)

  • Erythropoietin(EPO)


Chemokine
. Chemokine

Chemokines are cytokines which recruiting monocytes,granulocytes and lymphocytes in blood to the sites of inflammation.

  • CXC chemokines(α subgroup):IL-8

  • CC chemokines(β subgroup):MCP-1

  • C chemokines(γ subgroup)

  • CX3C chemokines(δ subgroup)

    *C: cysteine; X: any amino acid


Transforming growth factor
. Transforming growth factor

Growth-factor are cytokines which stimulate the growth of their target cells.

  • Transforming growth factor-(TGF- )

  • Epithelia growth factor(EGF)

  • Vascular endothelia cell growth factor(VEGF)

  • Fibroblastic growth factor(FGF)


Part ck receptor
PartⅢ CK receptor

1. Membrane-binding cytokine receptors:

The receptor consists of extra-cellular region, trans-membrane region and cytoplastic region.


CK receptors can be grouped into five families according to structure and function:

(1) Ig receptor superfamily:IL-1R,PDGFR,FGFR

(2) Type Ⅰ CK receptor superfamily: CSFR

(3) Type Ⅱ CK receptor superfamily: IFNR

(4) Type Ⅲ CK receptor superfamily: TNFR

(5) G-protein linked receptor superfamily: CCR5


Low affinity IL-2R to structure and function:

Moderate affinity IL-2R

High affinity IL-2R

IL-2

g

g

a

a

b

b

IL-2 receptor


Three f to structure and function:orms of the IL-2 Receptor

(CD25)



2.soluble cytokine receptor to structure and function:


Part biological functions of cytokines
Part to structure and function:Ⅳ Biological functions of cytokines

1.Take part in nonspecific immunity ------anti-bacteria, anti-virus

2. Take part in specific immunity

3. Stimulate hematopoiesis

4. Take part in inflammatory reaction


Part cytokine and disease
PartⅤ Cytokine and disease to structure and function:

  • Cytokines and diagnosis: IL-3, CSF

  • Cytokines and treatment: Th1 and Th2

  • Cytokines and disease prevention: CSF, IL-2

  • Cytokine assay


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