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手足口病医源性感染 预防与控制 - PowerPoint PPT Presentation


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手足口病医源性感染 预防与控制. 福建医科大学附属漳州市医院儿科 福建医科大学附属漳州市医院院感科 叶 小 玲 2009.04.21. 手足口病( hand-foot-mouth disease , HFMD ). 为全球性传染病,世界大部分地区均有流行的报道。 1957 年在加拿大首次报告,新西兰 Seddon 于 1957 年最早加以描述, 1958 年加拿大 Robinson 从患者粪便和咽拭中分离出 CoxA16 ,同时患者血清抗体有四倍增长 , 初步查明 CoxA16 为本病病原;

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手足口病医源性感染 预防与控制

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2009.04.21


hand-foot-mouth diseaseHFMD

  • 1957Seddon19571958RobinsonCoxA16,CoxA16

  • 1959HFMDHFMD

  • EV 71

  • 1


38

  • 2008.05.02

5

1

2

3

4

1. ; 2.

3. 4. 5.







HFMD

  • 1981HFMD

  • 1987CVA16

  • 1995HFMDEV71

  • 2007HFMD3960614EV71HFMDEcho3 / CVA16

  • 2008HFMD,HEV71,CVA16EV


2008

  • 48907337.01/100,000

    • 1165 0.24 %

    • 1260.0095/100,000 0.26


RNA

71EV71

(Coxasckie virus) A

16457910

(Coxasckie virus) B

2513

ECHO viruses

A16Cox A16

71EV 71



/


  • 560C

  • 20%418h

  • PH3.5

  • 75%5%



  • -


  • =1100

  • 3

  • 21035


    • 496~7





    • 2004292


    • .

    • ;



    • 1


    (

    1


    ethanol

    75%5%

    -





    • ICU

    • EV71


    -


    WHO

    1

    2

    3

    4

    5

    6




    2

    • 50C



    • 50C


    • 120.


    • 11120

    • 201000mg/L30


    • 81





    • .





    --



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