Zoonotic pathogens an introduction
Download
1 / 39

Zoonotic Pathogens: An Introduction - PowerPoint PPT Presentation


  • 262 Views
  • Updated On :

Zoonotic Pathogens: An Introduction . Dr. Emilo DeBess Oregon Health Division Dr. McKinley Thomas Augusta State University. Zoonotic Diseases. ...cause infections in animals and can be transmitted to humans …are typically endemic and occur in a natural foci

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'Zoonotic Pathogens: An Introduction' - mio


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
Zoonotic pathogens an introduction l.jpg

Zoonotic Pathogens: An Introduction

Dr. Emilo DeBess

Oregon Health Division

Dr. McKinley Thomas

Augusta State University


Zoonotic diseases l.jpg
Zoonotic Diseases

  • ...cause infections in animals and can be transmitted to humans

  • …are typically endemic and occur in a natural foci

    • However, ecologic changes and meteriologic or climate events can promote epidemic expansion of the host and geographic range.


History l.jpg
History

  • Interactions between animals and humans have occurred since the beginning of time.

  • As animals became domesticated and a close bonds developed between animals and humans, the occurrence of zoonotic diseases increased.


Significant zoonitic pandemics l.jpg
Significant Zoonitic Pandemics

  • 1700s, Mongols invaded Europe

  • Mongols carried plague with them

  • This lead to “black death” or plague pandemic

  • Killed 1/3 of European population


Significant zoonitic pandemics5 l.jpg
Significant Zoonitic Pandemics

  • Early 1900’s

  • “Spanish flu” transmitted from pigs to humans

  • Decimated 20 million people worldwide

  • Continues to pose a threat to humans


Contemporary threats l.jpg
Contemporary Threats

  • Potential Human Pathogens

    • E. coli 0157H7

    • Caliciviruses (evolved from the sea)

    • Bovine Spongiform Encephalopathy (BSE) also known as “mad cow disease”


Etiology l.jpg
Etiology

  • Today’s threat involving zoonotic diseases is considered to be partly due to human involvement in which the artificial multiplication of these pathogens can be used as biological terrorism.


Prevalence l.jpg
Prevalence

  • Largely Unknown

  • Both serological studies and anecdotal discussion have been used to generate estimates

    • 1997 a study trying to asses the prevalence of antibodies against Bartonella henselae and B. quintana was done at a veterinary conference. The results indicated that 7.1% of the veterinary population had antibodies which was no different from the general population studies at an earlier time.


Believed more common l.jpg
Believed More Common

  • Ringworm caused by Trychophitum species. believed to be heavily under diagnosed / not reported

  • More prevalent among children


Common zoonotic diseases l.jpg
Common Zoonotic Diseases

  • Bacterial

    • Plague

    • Cat Scratch Fever

    • Salmonellosis

  • Parasitic

    • Toxoplasmosis

    • Ring Worm

  • Viral

    • Hantavirus

    • Prion

      • BSE



Slide14 l.jpg

Plague in History

  • Pandemics in history involving Europe, Asia, Africa

  • “The Black Death,” thought to be caused by displeasure of the gods or other supernatural powers, heavenly disturbances

  • The etiologic agent, Yersinia pestis, first isolated in 1894 (Yersin and Kitasato)


Cat scratch disease l.jpg
Cat Scratch Disease

  • One estimate by the Centers for Disease Control found that there were 2.5 cases of CSD per 100,000 people per year in the United States.

  • In recent years, many studies have implicated the gram negative bacterium Bartonella henselae as the primary (but not the sole) cause of CSD

  • Typically, a small skin lesion (resembling an insect bite) develops at the site of a cat scratch or (less commonly) a bite, followed within two weeks by swollen lymph nodes and sometimes a fever.


Cat scratch disease16 l.jpg
Cat Scratch Disease

  • Cats are the main reservoir for B. henselae. Surveys for B. henselae antibodies in cats in the United States have found average infection rates to be from 25% to 41% in clinically healthy cats.

  • The lowest rates were in the Midwest and great plains regions (4-7%) and the highest were in the southeast (60%). Warmer, more humid climates are most supportive of fleas, which have been shown to transmit B. henselae from cat to cat.

  • It appears that the majority of cats do not become ill when they are infected with this bacterium and kittens are more commonly infected than adults.


Cat scratch disease17 l.jpg
Cat Scratch Disease

  • CSD is primarily a concern in homes with immunosuppressed people.

  • Since kittens are more likely to carry B. henselae than adult cats, it is recommended that people with compromised immune systems adopt cats older than 1 year of age to reduce the risk of contracting CSD.


Cat scratch disease18 l.jpg
Cat Scratch Disease

  • Since carrier cats are always healthy and multiple

  • cases of CSD within a household are rare, euthanasia of a suspected carrier is not warranted.

  • Onychectomy (declawing) is also not recommended, since infection can occur without a cat scratch.

  • As is always the case, any cut or scratch should be promptly washed with soap and water.


Reptile associated salmonellosis l.jpg
Reptile-Associated Salmonellosis


Slide20 l.jpg

Reptile-associated Human Salmonella

History

1944 First Salmonella sp. isolate from snakes.

1946 First Salmonella sp. isolate from turtles and lizards.

1963 Turtle-associated salmonellosis first described.

1972 FDA regulation requiring certification of turtles for sale as

"Salmonella-free."

1974 Study shows 300,000 turtle-associated human

salmonellosis cases per year in U.S.

1975 FDA bans sale of viable turtle eggs or live turtles with

carapace length < 10.2 cm.

1977 CA State regulations ban sale, as above.


Reptile associated salmonellosis21 l.jpg
Reptile-Associated Salmonellosis

  • In the United States, pet turtles were an important source of salmonellosis until commercial distribution of pet turtles less than 4 inches long was banned in 1975.

  • This ban led to a 77% reduction in the frequency of turtle-associated Salmonella serotypes isolated from humans during 1970-1976.


Reptile associated salmonellosis22 l.jpg
Reptile-Associated Salmonellosis

  • Approximately 93,000 (7%) cases per year of Salmonella infections are attributable to pet reptile or amphibian contact.

  • An estimated 3% of households in the United States have a reptile (CDC, unpublished data, 1999)


Reptile associated salmonellosis23 l.jpg
Reptile-Associated Salmonellosis

  • Kansas. During April 1997, a 6-year-old boy had bloody diarrhea of 10 days' duration, abdominal cramps,vomiting, and fever (104.9 F [41 C]). Stool culture yielded Salmonella serotype Typhimurium. The child was treated with ceftriaxone and amoxicillin / clavulanate.

  • Nine days after the boy started therapy, his 3-year-old brother also developed diarrhea, and a stool sample yielded S. Typhimurium..


Reptile associated salmonellosis24 l.jpg
Reptile-Associated Salmonellosis

  • No other family members became ill. The two boys shared a room with two corn snakes that they handled regularly. Stool cultures from the corn snakes yielded S. Typhimurium.

  • The parents reported to health department staff that they were unaware that snakes are a source of salmonellosis


Slide25 l.jpg

Salmonella Infection in Reptiles

  • Numerous serotypes reported (5 or more may be isolated from a single reptile specimen).

  • Latent infections with reactivation resulting in intermittent shedding

  • Usually asymptomatic (wound infections, septic arthritis, endocarditis reported after inoculation via bites/scratches).

DIFFICULT TO IDENTIFY OR ELIMINATE CARRIERS.

Chiodini RJ, Am J Epidemiol 1981.



Slide27 l.jpg

Recommendations to Prevent Human

Reptile-associated Salmonellosis

  • Do not keep reptiles as pets where high risk individuals may be exposed such as infants, the elderly, and people with compromised immune systems.

  • Thoroughly wash hands after any contact with reptiles, including handling of the animal or its cage.

  • Confine reptiles to prevent environmental contamination. For example, keep reptiles off of floors and rugs where infants crawl and out of tubs and sinks where infants are bathed.


Toxoplasmosis l.jpg
Toxoplasmosis

  • Toxoplasmosis is a disease caused by microscopic parasite called Toxoplasma gondii.

  • It is not a new disease, having first been discovered in 1908. Since its discovery, toxoplasmosis has been found in virtually all warm-blooded animals including most pets, livestock, and human beings.

  • Nearly one-third of all adults in the U.S. and in Europe have antibodies to Toxoplasma, which means they have been exposed to this parasite.


Toxoplasmosis29 l.jpg
Toxoplasmosis

  • There are 3 principal ways Toxoplasmosis is transmitted:

  • 1.Directly from pregnant mother to unborn child when the mother becomes infected with Toxoplasmosis during pregnancy.

  • 2.Consumption and handling of undercooked or raw meat from infected animals.

  • 3.Ingestion of food or water or inhalation of dust contaminated with a very resistant form of Toxoplasmosis called the oocyst.


Toxoplasmosis30 l.jpg
Toxoplasmosis

  • Toxoplasma in meat can be killed by cooking at 152ºF (66ºC) or higher or freezing for a day in a household freezer.

  • Of all the infected animals tested, only cats are the perfect hosts for the production of the infectious and resistant Toxoplasma oocysts.


Toxoplasmosis31 l.jpg
Toxoplasmosis

  • There are two populations at high risk for infection with Toxoplasma; pregnant women and immunosuppressed individuals. In the United States it is estimated that approximately 3,000 children are born infected with toxoplasmosis every year.

  • Although the majority of infected infants show no symptoms of toxoplasmosis at birth, many are likely to develop signs of infection later in life.

    Loss of vision, mental retardation, loss of hearing, and death in severe cases, are the symptoms of toxoplasmosis in congenitally infected children.




Slide34 l.jpg

Hantavirus Pulmonary Syndrome Cases

by State of Residence

22

14

7

1

2

2

5

6

1

14

2

3

1

5

1

12

1

2

1

14

24

1

14

33

1

1

31

41

1 - 5 cases

6 - 10 cases

1

11 -15 cases

13

1

>15 cases

277 cases in 31 states

10/4/2000


Slide35 l.jpg

Transmission of Hantaviruses

Chronically infected rodent

Horizontal transmission of infection by intraspecific aggressive behavior

Virus also present in throat swab and feces

Virus is present in aerosolized excreta, particularly urine

Secondary aerosols, mucous membrane contact, and skin breaches are also a consideration



Slide37 l.jpg
BSE

  • Since 1996, evidence has been increasing for a causal relationship between ongoing outbreaks in Europe of a disease in cattle, called Bovine Spongiform Encephalopathy (BSE, or "mad cow disease"), and a disease in humans, called new variant Creutzfeldt-Jakob disease (nvCJD).

  • Both disorders are invariably fatal brain diseases with unusually long incubation periods measured in years, and are caused by an unconventional transmissible agent.


Ringworm l.jpg
Ringworm

  • Ringworm is a fungus infection of the scalp or skin. Symptoms include a rash that is often itchy and flaky

  • Ringworm is spread by direct contact with a person or animal infected with the fungus.

  • The same fungi that infect humans can also infect animals such as dogs, and cats, and infections may be acquired from pets as well as from infected children.


Bibliography l.jpg
Bibliography

  • Swedish Institute of Infectious Disease Control. (2001). Available: http://www.smittskyddsinstitutet.se/

  • Control of Communicable Diseases Manual James Chin, MD 17th edition

    Centers for Disease Control and Prevention www.cdc.gov

    We would like to acknowledge Michelle Jay, DVM,MPVM for providing materials for this presentation.


ad