Pharmacometrics
This presentation is the property of its rightful owner.
Sponsored Links
1 / 16

PHARMACOMETRICS PowerPoint PPT Presentation


  • 125 Views
  • Uploaded on
  • Presentation posted in: General

PHARMACOMETRICS. Systems Pharmacology Quantitative Pharmacology Pharmacokinetics on Steroids. Noncompartmental Analyses. WinNonlin Area-under-the-curves (AUCs) Cmax Tmax Half-life Bioavailability fraction. Compartmental Modeling. Assume model

Download Presentation

PHARMACOMETRICS

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


Pharmacometrics

PHARMACOMETRICS

Systems Pharmacology

Quantitative Pharmacology

Pharmacokinetics on Steroids


Noncompartmental analyses

Noncompartmental Analyses

  • WinNonlin

  • Area-under-the-curves (AUCs)

  • Cmax

  • Tmax

  • Half-life

  • Bioavailability fraction


Compartmental modeling

Compartmental Modeling

  • Assume model

  • Nonlinear regression to get CL, Vd, Ka, K12, K21, half-life, Vmax, Km, Emax, EC50


Pharmacometrics

Line of Best Fit


Population modeling

Population Modeling

  • Sometime data are sparse and one cannot estimate PK parameters with much certainty in any individual

  • An alternative approach is nonlinear mixed-effects modeling in which the experimental unit of interest is the population, NOT the individual

  • Average CL, average Volume, etc., and importantly, their associated variabilities


Pharmacometrics

Gtn: gastrin

SS: somatostatin

Hist: histamine

ECL cell: enterochromaffin-like cells

PC: parietal cells


Pharmacometrics

Gastrin


Pharmacometrics

Ranitidine in the model


Pharmacometrics

Ranitidine Bolus


  • Login