Pharmacometrics
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PHARMACOMETRICS. Systems Pharmacology Quantitative Pharmacology Pharmacokinetics on Steroids. Noncompartmental Analyses. WinNonlin Area-under-the-curves (AUCs) Cmax Tmax Half-life Bioavailability fraction. Compartmental Modeling. Assume model

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PHARMACOMETRICS

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Pharmacometrics
PHARMACOMETRICS

Systems Pharmacology

Quantitative Pharmacology

Pharmacokinetics on Steroids


Noncompartmental analyses
Noncompartmental Analyses

  • WinNonlin

  • Area-under-the-curves (AUCs)

  • Cmax

  • Tmax

  • Half-life

  • Bioavailability fraction


Compartmental modeling
Compartmental Modeling

  • Assume model

  • Nonlinear regression to get CL, Vd, Ka, K12, K21, half-life, Vmax, Km, Emax, EC50


Pharmacometrics

Line of Best Fit


Population modeling
Population Modeling

  • Sometime data are sparse and one cannot estimate PK parameters with much certainty in any individual

  • An alternative approach is nonlinear mixed-effects modeling in which the experimental unit of interest is the population, NOT the individual

  • Average CL, average Volume, etc., and importantly, their associated variabilities


Pharmacometrics

Gtn: gastrin

SS: somatostatin

Hist: histamine

ECL cell: enterochromaffin-like cells

PC: parietal cells





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