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Carlos Montalvo Foy H. Moody High School; Corpus Christi ISD Faculty Mentor: Dr. Zhengdong Cheng

What is Research?. Cheng Group Research. Carlos Montalvo Foy H. Moody High School; Corpus Christi ISD Faculty Mentor: Dr. Zhengdong Cheng Artie McFerrin Dept. of Chemical Engineering. Dr. Zhengdong Cheng. B.S., University of Science and Technology of China, Hefei, China, 1990

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Carlos Montalvo Foy H. Moody High School; Corpus Christi ISD Faculty Mentor: Dr. Zhengdong Cheng

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  1. What is Research? Cheng Group Research Carlos Montalvo Foy H. Moody High School; Corpus Christi ISD Faculty Mentor: Dr. Zhengdong Cheng Artie McFerrin Dept. of Chemical Engineering

  2. Dr. Zhengdong Cheng • B.S., University of Science and Technology of China, Hefei, China, 1990 • M.S., Institute of High Energy Physics, Beijing, China, 1993 • Ph.D., Princeton University, 1999 • Postdoc, ExxonMobil, 1999-2000 • DiCon Fiberoptics Inc., 2001-2002 • Postdoc, Harvard Universtiy, 2002-2004

  3. Main Focus • Colloid Chemistry • Colloid—type of mechanical mixture where one substance is dispersed evenly throughout another.

  4. Aspects of Research • Colloidal Crystal Growth • Engineering and ordering large crystals to create photonic band gaps for optical computers • Discotic Colloids • Study the flow and movement of disk like molecules such as red blood cells • Cell Encapsulation • Using microreactors to create a protective “bubble” over a cell for possible drug delivery

  5. Crystal Structure Review

  6. 0 min 4 min 11 min 25 min 89 min 152 min How are Colloids and Crystal structures related? • Colloidal Crystals!!

  7. Reason for Understanding Colloidal Crystals • Optical Computers

  8. Optical Computer

  9. Wax with 1% STADIS-450 • Flow Rate : 4ml/h • Voltage: 2.8 kV Discotic Colloids • Emulsification—process by which one liquid is dispersed into another in the form of small droplets (http://www.pwsrcac.org/resources/glossary.html)

  10. Electrospray • Electrospray • Ionization technique where droplets are created in an electric field • An electric force is applied to a liquid surface

  11. Wax Emulsion • Eicosene (wax) • Formation of droplets • Lower temperature to form disks

  12. Disk Forming • Electrospray cooling forms disks similar to shape of Red Blood Cell

  13. Cell Encapsulation • Placing a cell into a protective membrane that is not immunosuppressed.

  14. Advantages • Immunoisolation • Natural therapeutic response • Applications • Diabetes (type I) • Hemophilia • Cancer • Renal failure Cell Encapsulation: concept • Encapsulate cells of interest in semi-permeable membrane • Implant cell capsules • Cells release therapeutic substances Dr. Dawei Luo

  15. Cell Encapsulation • Confocal microscope imaging shows the uniform shape of alginate disks. • Fluorescence shows successful encapsulation of colloidal particles.

  16. water oil oil oil oil water Microfluidics • Microfluidics

  17. Microfluidics • Microreactors using microfluidics

  18. Experiments to be Conducted • Formation of microdisks using Electrospray technique

  19. Droplet Formation Using Electrospray

  20. Experiments to be Conducted • Study the size and variation of the wax disks as electrospray settings are changed • Study how the disks flow through various substances (ie.—red blood cell flow) • Observe and study encapsulation techniques • Attempt to add protective coating to encapsulations

  21. In Summary.... • Aspects of Research • Colloidal crystal growth • Disk formation using Electrospray • Cell encapsulation using Electrospray and microfluidics • Classroom Activities???

  22. Acknowledgements • Dr. Zhengdong Cheng • Andres Mejia • Lucas Kinard • National Science Foundation

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