C2 training may 9 10 2011
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C2 Training: May 9 – 10, 2011. Data Evaluation: Initial screening and Coding Adapted from David B. Wilson and Mark W. Lipsey. Overview. Coding protocol: essential feature of systematic review Goal: transparent and replicable description of studies extraction of findings

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C2 Training: May 9 – 10, 2011

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C2 training may 9 10 2011

C2 Training: May 9 – 10, 2011

Data Evaluation: Initial screening and Coding

Adapted from David B. Wilson and Mark W. Lipsey


Overview

Overview

  • Coding protocol: essential feature of systematic review

  • Goal: transparent and replicable

    • description of studies

    • extraction of findings

  • Forms should be part of C2 protocol


Topics

Topics

  • Eligibility criteria and screening form

  • Development of coding protocol

  • Assessing reliability of coding

  • Common mistakes


Study eligibility criteria

Study Eligibility Criteria

  • Flow from research question

  • Identify specifics of:

    • Defining features of the program/policy/intervention

    • Eligible designs; required methods

    • Key sample features

    • Required outcomes

    • Required statistical data

    • Geographical/linguistic restrictions, if any

    • Time frame, if any

  • Also explicitly states what is excluded


Study eligibility screening form

Study Eligibility Screening Form

  • Develop a screening form with criteria

  • Complete form for all studies retrieved as potentially eligible

  • Modify criteria after examining sample of studies (controversial)

  • Double-code eligibility

  • Maintain database on results for each study screened

  • Example from MST review in handouts


Screening form

Screening Form

Effects of Multisystemic Therapy (MST)

Initial Screening Form 1.0


C2 training may 9 10 2011

Effects of Multisystemic Therapy (MST): Eligibility Screening Form 1.2


Screening coding guide for internet based interventions for english language learners

Screening Coding Guide for “Internet-based Interventions for English Language Learners”


Coding practice exercise 1

Coding practice exercise 1

  • For the articles provided, code Levels 1 and 2 from the MST coding sheet

  • Use Brunk and either Bourduin or Henggler & Melton


Development of coding protocol

Development of Coding Protocol

  • Goal of protocol

    • Describe studies

    • Differentiate studies

    • Extract findings (effect sizes if possible)

  • Coding forms and manual

    • Both important

    • Sample coding item from form

    • Sample manual instructions for item


Development of coding protocol1

Development of Coding Protocol

  • Types of Information to Code

    • Setting, study context, authors, publication date and type, etc.

    • Methods and method quality

    • Program/intervention

    • Participants/clients/sample

    • Outcomes

    • Findings, effect sizes


Types of information to code

Types of Information to Code

  • Setting, study context, authors, publications date and type, etc.

    • Multiple publications; “study” vs “report”

    • Geographical/national setting; language

    • Publication type and publication bias issue

    • Publication date vs study date

    • Research, demonstration, practice studies

    • Example from MST review in handouts


Types of information to code1

Types of Information to Code

  • Methods: Basic research design

    • Nature of assignment to conditions

    • Attrition, crossovers, dropouts, other changes to assignment

    • Nature of control condition

    • Multiple intervention and/or control groups

  • Design quality dimensions

    • Initial and final comparability of groups

    • Treatment-control contrast

      • treatment contamination

      • blinding


Types of information to code2

Types of Information to Code

  • Methods: Other aspects

    • Issues depend on specific research area

    • Procedural, e.g.,

      • monitoring of implementation, fidelity

      • credentials, training of data collectors

    • Statistical, e.g.,

      • statistical controls for group differences

      • handling of missing data


Types of information to code3

Types of Information to Code

  • Method quality ratings (or not)

  • More than 200 scales and checklists available, few if any appropriate for systematic reviews (Deeks et al., 2003)

  • Overall study quality scores have questionable reliability/validity (Jüni et al., 2001)

    • Conflate different methodological issues and study design/implementation features, which may have different impacts on reliability/validity

    • Preferable to examine potential influence of key components of methodological quality individually

  • Weighting results by study quality scores is not advised!


Cochrane risk of bias framework

Cochrane risk of bias framework

  • Focus on identifying potential sources of bias in studies:

  • Selection bias - Systematic differences between groups at baseline

  • Performance bias - Something other than the intervention affects groups differently

  • Attrition bias - Participant loss affects initial group comparability

  • Detection bias - Method of outcome assessment affects group comparisons

  • Reporting bias - Selective reporting of outcomes


Grade system for method quality

GRADE system for method quality

  • Quality of evidence across trials

  • Outcome-specific

  • Considers: sparse data, consistency/inconsistency of results across trials, study designs, reporting bias, possible influence of confounding variables

  • Software available at: www.ims.cochrane.org/revman/gradepro

  • Also see: www.gradeworkinggroup.org


Types of information to code4

Types of Information to Code

  • Program/Intervention

    • General program type (mutually exclusive or overlapping?)

    • Specific program elements (present/absent)

    • Any treatment received by the comparison group

    • Treatment implementation issues

      • integrity

      • amount, “dose”

    • Goal is to differentiate across studies

    • Examples


Types of information to code5

Types of Information to Code

  • Participants/clients/sample

    • Data is at aggregate level

    • Mean age, age range

    • Gender mix

    • Racial/ethnic mix

    • Risk, severity

    • Restrictiveness; special groups (e.g., clinical)

    • Examples


Types of information to code6

Types of Information to Code

  • Outcome measures

    • Construct measured

    • Measure or operationalization used

    • Source of information

    • Composite or single indicator (item)

    • Scale: dichotomous, count, discrete ordinal, continuous

    • Reliability and validity

    • Time of measurement (e.g., relative to treatment)

    • Examples


Types of information to code7

Types of Information to Code

  • Findings

    • Compute effect sizes when possible

    • May need to aggregate data or reconfigure findings

      • Add back the “dropouts”

      • Compute weighted means of subgroups (e.g., boys and girls)

    • Code data on which computations based (common situations)

    • We will look at this part of the coding in the next section


Development of coding protocol2

Development of Coding Protocol

  • Iterative nature of development

  • Structuring data

    • Data hierarchical (findings within studies)

    • Coding protocol needs to allow for this complexity

    • Analysis of effect sizes needs to respect this structure

    • Flat-file (example)

    • Relational hierarchical file (example)


Data extraction

Data extraction

Double data extraction

  • Cohen’s kappa

  • Agreement on key decisions

    • Study inclusion/exclusion, key characteristics, risk of bias, coding of results

  • Pilot-test and refine codes!


Example of a flat file

Example of a Flat File

Multiple ESs handled by having multiple

variables, one for each potential ES.

Note that there is only one record (row) per study


Example of a hierarchical structure

Example of a Hierarchical Structure

Study Level Data File

Effect Size Level Data File

Note that a single record in the file above is “related” to five records in the file to the right


Coding exercise 2

Coding exercise 2

  • For either Borduin or Henggler & Melton, please code the Level 3 items (do not do the outcomes and effect sizes)

  • Report back: what was easy/difficult?


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