Pharming Overview
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Pharming Overview. May 2006.

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Pharming Overview

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Pharming overview

Pharming Overview

May 2006

This presentation contains forward looking statements that involve known and unknown risks, uncertainties and other factors, which may cause the actual results, performance or achievements of the Company to be materially different from the results, performance or achievements expressed or implied by these forward looking statements.

Powered by Bioscience, Focused on Products


Overview

Overview

  • Based in Leiden, Netherlands and USA

  • Euronext listing;1989 - 2001 ‘Research Era’

  • Production of recombinant proteins for restoration and repair

  • Role of protein cascades (Complement, Clotting)

  • 2002 - 2005 ‘Turnaround & Refocus’

  • 240 40 60 employees

  • Lead product rhC1INH being filed for HAE

  • Clinical work on major new indications

  • rhLactoferrin filed for GRAS indication in USA

  • rhFibrinogen and rhCollagen development

  • Novel protein manufacturing system validated

History

Technology

Organisation

Products


Pharming overview

Strategic Evolution

Survival

Focus

Innovation

Collaboration

  • Financing

  • Research

  • Organisation

  • rhC1 INH

  • rh LF

  • Cash Flow

  • Restructuring

  • Compassionate Use

  • Manufacturing

  • Marketing

  • Diosynth

  • Paul Capital

  • Novathera

  • DNage

2001A2002A2004A2005A2006 - 07

Equity€ (1) M € 11 M€ 36 M€ 29 M€ 50 M +

Debt € (24) M€ (5) MNear Zero Near ZeroNear Zero

Annual Loss€ (54) M€ (1) M € (14) M € (18) MZCB

Employees25040 48 6060+

Products11 4 4+6+

Mkt Cap€ 4 M€ 16 M€ 150 M€ 325 M


Pharming overview

Product Pipeline

Accelerate Product Flow to the Market

Status

Product

Application

Market Size

rhC1INH

rhFibrinogen

rhFib Sealant

rhLactoferrin

rhCollagen

Novathera Combos

Technology

> € 500 million

> € 1 billion

> € 1 billion

€ 100 million

> € 1 billion

> € 1 billion

> € 1 billion

> € 1 billion

Phase III

Filing in first market

In the clinic

Intermediate

Device

Food (GRAS)

Device

Intermediate

Device

Under

Development

Licensing

  • HAE

  • New Indications

  • Intermediate

  • Control bleeding

  • Nutraceutical

  • Anti-infective

  • Intermediate

  • Cosmetic / Other

  • Tissue Repair

  • Catheters, Stents

  • Protein Production


Protein production technology

Protein ProductionTechnology

Select

protein

Generate

genetic

constructs

Develop

founder/

mini-herd

Expand

herd

Purify

protein

from milk

Formulate

Protein

therapeutic


Hae patient centric approach

HAE - Patient Centric Approach

A congenital deficiency of functional C1 inhibitor (C1INH) characterised by recurrent

localised angioedema due to uncontrolled activation of complement and contact systems

22,000 patients, 160,000 attacks per year

relationship with patient organizations

facilitating

patient care

Patient

Register

share information with regulatory authorities

relationships with key opinion leaders


Rec human c1 inhibitor phase iii for hae

Rec. Human C1 inhibitor Phase III for HAE

  • Rapid relief

  • (usually 15 minutes)

  • Complete resolution

  • (12 - 24 hours)

  • No ADRs reported

  • Report published

  • April 2005


Rec human lactoferrin filed with us fda for gras

Rec. Human LactoferrinFiled with US FDA for GRAS

  • For functional and

  • sport foods

  • Doses of upto 2g/kg in

  • toxicity studies

  • Safe for oral use

  • Report published

  • Jan 2006


Future outlook 2006 08 capitalize on solid financial position

Future Outlook 2006 – 08Capitalize on solid financial position

  • Strong news flow from filings, partnerships and launches for rhC1INH and rhLF

  • Partnerships for Pharming technology platforms and product pipeline

  • Generate sustainable revenues via rhC1INH and rhLF launches

  • Establish critical mass to build a biotechnology company with world class R&D and commercial capabilities


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