1 / 18

Ebola

Dan- Thanh Nguyen Biology 402 March 20, 2012. Ebola. EBOV is a viral hemorrhagic fever with an incubation period of 2-21 days. Symptoms: Fever Sore throat Weakness Headache Muscle aches Diarrhea Vomiting Severe hemorrhaging. Ebola has a high case fatality ratio of 25-90%.

michi
Download Presentation

Ebola

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Dan-Thanh Nguyen Biology 402 March 20, 2012 Ebola

  2. EBOV is a viral hemorrhagic fever with an incubation period of 2-21 days Symptoms: • Fever • Sore throat • Weakness • Headache • Muscle aches • Diarrhea • Vomiting • Severe hemorrhaging

  3. Ebola has a high case fatality ratio of 25-90% http://www.all-science-fair-projects.com/science_fair_projects_encyclopedia/Ebola

  4. Transmission occurs with close personal contact with infected individuals

  5. Ebola has nonhuman hosts http://www.reviews-technology.com/2010_08_24_archive.html

  6. Candidate reservoir hosts are mammals of small body size, and asymptomatic http://www.mnzoo.org/faces/fruit-bat/

  7. http://www.who.int/csr/disease/ebola/Global_EbolaOutbreakRisk_20090510.pnghttp://www.who.int/csr/disease/ebola/Global_EbolaOutbreakRisk_20090510.png

  8. Ebola is in the family of filoviruses and a cousin of the Marburg Virus http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277274/?tool=pmcentrez

  9. Ebola virus is subdivided into five different species based on where they were discovered • Zaire (Democratic Republic of Congo) • Sudan • Cote d’Ivoire (Ivory Coast) • Reston • Bundibugyo

  10. Ebola is an enveloped, single-stranded RNA virus http://viralzone.expasy.org/all_by_species/23.html

  11. Ebola virus has a negative strand RNA genome Nucleoprotein Virion protein 40 Virion protein 30 polymerase Virion protein 35 Virion protein 24 Glycoprotein Soluble glycoprotein http://viralzone.expasy.org/all_by_species/23.html

  12. During replication, full-length positive-sense copies of the genome are synthesized http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277274/?tool=pmcentrez

  13. Filoviruses have broad tissue tropism but have preferred target cells • Hepatocytes • Endothelial cells • Dendritic cells • Monocytes • Macrophages

  14. EBOV accelerates the release of pro-inflammatory cytokines http://www.nature.com.libproxy.lib.unc.edu/nri/journal/v3/n8/full/nri1154.html#f3

  15. http://www.nature.com.libproxy.lib.unc.edu/nri/journal/v7/n7/full/nri2098.htmlhttp://www.nature.com.libproxy.lib.unc.edu/nri/journal/v7/n7/full/nri2098.html

  16. Hemorrhaging is related to disseminated intravascular coagulation (DIC) and increase in tissue factor in macrophages http://jid.oxfordjournals.org/content/188/11/1618.full

  17. There is currently no definitive vaccine for Ebola virus. http://buquad.com/2011/10/17/bu-biolab/ http://www.nationalpost.com/related/topics/Canadian+scientists+develop+Ebola+treatment/3083100/story.html

  18. Resources • Dolnik, O.; L. Kolesnikova, and S. Becker. “Filoviruses: Interactions with the host cell.” Cellular and Molecular Life Sciences Vol 65. 756-776. 2008. http://www.springerlink.com/content/fk38279221156248/ • “Ebola haemorrhagic fever.” World Health Organization. Dec 2011. http://www.who.int/mediacentre/factsheets/fs103/en/ • “Ebola virus disease.” Wikipedia. http://en.wikipedia.org/wiki/Ebola_virus_disease • Feldmann, Heinz; Steven Jones, Hans-Dieter Klenk; and Hans-Joachim Schnittler. “Ebola virus: from discovery to vaccine.” Nature Reviews Immunology. Vol 3. 677-685 (August 2003). http://www.nature.com.libproxy.lib.unc.edu/nri/journal/v3/n8/full/nri1154.html#f3 • Geisbert, Thomas et al. “Mechanisms Underlying Coagulation Abnormalities in Ebola Hemorrhagic Fever: Overexpression of Tissue Factor in Primate Monocytes/Macrophages is a Key Event.” Journal of Infectious Diseases. Vol 188. 1618-1629. 2003. http://jid.oxfordjournals.org/content/188/11/1618.full.pdf+html • Mohamadzadeh, Mansour; Leiping Chen; and Alan L. Schmaljohn. “How Ebola and Marburg viruses battle the immune system.” Nature Reviews Immunology. Vol 7. 556-567 (July 2007). http://www.nature.com.libproxy.lib.unc.edu/nri/journal/v7/n7/full/nri2098.html • Takada, Ayato. “Filovirus Tropism: Cellular Molecules for Viral Entry.” Frontiers in Microbiology. 06 February 2012. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277274/pdf/fmicb-03-00034.pdf

More Related