Institutional Animal Care and Use Committee (IACUC)

1. Institutional Animal Care and Use Committee (IACUC) The IACUC provides internal oversight of animal: - husbandry - facilities - use in teaching & research The ASU IACUC consists of 11 voting members plus other supporting participants who include: - faculty representing the various departments and uses of animals - representatives of relevant ASU service departments - DACT (including the Attending Veterinarian) - EH&S - Campus Health - VPREA Office - Risk Management - non-affiliated member

2. Institutional Animal Care and Use Committee (IACUC) • Web site includes: • Policy and Procedure Manual • forms • training instructions and exams • Occupational Health & Safety Program documents • Standard Institutional Guidelines • protocol due dates & meeting dates • Animal Welfare Assurance & USDA certificate numbers • society non-traditional species guidelines • AVMA euthanasia guidelines • federal regulations • etc. http://researchintegrity.asu.edu/ animals iacuc

3. October 28-29, 2009 March 5-6, 2009 Institutional Animal Care and Use Committee (IACUC) • Last year’s 2 aims as the new Chair: • To assure that ASU meets all regulatory requirements • - USDA – enforces the Animal Welfare Act. Definition of “animal”? • - OLAW (Office of Laboratory Animal Welfare) – oversees the use of non-human vertebrates in PHS-supported research (PHS Policy on Humane Care and Use of Laboratory Animals, 2002) • - AAALACi (Association for the Assessment & Accreditation of Laboratory Animal Care International) – voluntary, covers all non-human vertebrates at the institution • - U.S. Fish & Wildlife Service – oversees federally protected species and international transport of all vertebrate animals and their parts • - Arizona Game & Fish Department – oversees the capture & holding of native wildlife, as well as the holding of restricted non-native wildlife • - Arizona Department of Health Services – covers species where there is a concern for zoonotic disease All mammals except laboratory mice & rats

4. ASU-BNI agreement Institutional Animal Care and Use Committee (IACUC) • Last year’s 2 aims as the new Chair: • To minimize the burden on investigators (provided it does not interfere with Aim 1) • - Require IACUC training and certification specific to the investigator, not the protocol. • - Eliminate the need for duplicative protocols in situations where a PI conducts work at multiple local institutions. • - ??

5. Institutional Animal Care and Use Committee (IACUC) • The review process (details in the Policy & Procedure Manual): • Protocols: • - pre-reviewed by the Attending Veterinarian, then one other IACUC member (assigned by the Chair as the Primary Reviewer) • - reviewed by the full committee at a convened meeting in the presence of the PI or designee • Amendments: • - Minor – administratively approved by the Chair • - Significant – with the approval of the full committee, reviewed by a Designated Reviewer (assigned by the Chair) and the Attending Veterinarian • - Major – reviewed by full committee at a convened meeting - a change that does not in any way effect the animals • the rationale for the new procedure is consistent with the research goals in the approved protocol • involves no increased risk of pain, distress, or discomfort to animals • does not markedly increase, by absolute or relative terms, the number of animals involved in the project

6. Changes to the Protocol Form Why were there changes? • - section for Additional Contact information • - split the literature search into two separate searches • - duplicative research • - alternatives to animal use and painful procedures • includes section to summarize results • pay close attention to the search words used • - method of animal identification, if any • Regulatory oversight is very dynamic, expect more changes! • - qualifications and training of all participants • (in protocols and added in an amendment) MAKE SURE TO USE THE MOST CURRENT FORM! (available on the web site)