Cat # PKI-SB202-010

1. SB 202190 Size: 10 mg M.W.=335.85 Batch No.: 1A/2006125 15875 Gaither Drive Gaithersburg, MD 20877 FAX. 301-560-4919 TEL. 301-330-5966 Toll Free. 1-866-918-6812 Email: info@signagenlabs.com Web: www.signagenlabs.com Cat # PKI-SB202-010 This product is for laboratory research ONLY and not for diagnostic use Description:A highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. Binds within the ATP pocket of the active kinase (K d = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38 α and β isoforms (IC 50 = 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38 β2 respectively). PHYSICAL AND CHEMICAL PROPERTIES Batch Molecular Formula: C20H14N3OF.¼H2O Batch Molecular Weight: 335.85 CAS Number: [152121-30-7] Physical Appearance: Off-white crystalline solid Solubility: DMSO to 100 mM Batch Molecular Structure: References:1. Jiang et al (1996) Characterization of the structure and function of a new mitogen-activated protein kinase (p38 β ). J.Biol.Chem. 271 17920. 2. Frantz et al (1998) The activation of p38 mitogen-activated protein kinase determines the efficiency of ATP competition for pyridinylimidazole inhibitor binding. Biochemistry 37 13846. 3. Nemoto et al (1998) Induction of apoptosis by SB 202190 through inhibition of p38 β mitogen-activated protein kinase. J.Biol.Chem. 273 16415. 4. Davies et al (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J. 351 95. Storage:Desiccate at -20 C . Product shipped at ambient temperature. 2006 SignaGen Laboratories