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ENFERMEDADES GENERADAS POR CONTAMINANTES

ENFERMEDADES GENERADAS POR CONTAMINANTES. CONTAMINANTES QUE GENERAN ENFERMEDADES. EL PROBLEMA TAMBIÉN ES LA DOSIS. EL PROBLEMA TAMBIÉN ÉS EL TIEMPO. ORGANOCHLORINE COMPOUNDS ARE TOXIC COMPOUNDS AT HIGH CONCENTRATIONS. PORPHYRIA CUTANEA TARDA. HEXACHLOROBENZENE.

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ENFERMEDADES GENERADAS POR CONTAMINANTES

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  1. ENFERMEDADES GENERADAS POR CONTAMINANTES

  2. CONTAMINANTES QUE GENERAN ENFERMEDADES

  3. EL PROBLEMA TAMBIÉN ES LA DOSIS

  4. EL PROBLEMA TAMBIÉN ÉS EL TIEMPO

  5. ORGANOCHLORINE COMPOUNDS ARE TOXIC COMPOUNDS AT HIGH CONCENTRATIONS

  6. PORPHYRIA CUTANEA TARDA HEXACHLOROBENZENE

  7. CHLORACNE by EXPOSURE TO DIOXINS AUGUST 2004 NOVEMBER 2004 V. Yushchenko

  8. Newborn with in-utero growth delay and skin hyperigmentation due to in-utero exposure to PCBs (Kyushu,Japan, 1968)

  9. ORGANOCHLORINE COMPOUNDS WERE NOT PRESENT IN THE ENVIRONMENT NOR IN HUMAN BODIES SIXTY YEARS AGO THEREFORE OUR METABOLISM IS NOT READY TO HANDLE THEM (which is not the case for PAH)

  10. POLYCYCLIC AROMATIC HYDROCARBONS

  11. PAH metabolites • 1-naphthol • 2-fluorenol • 9-phenanthrol • 1-pyrenol • 3-benzo[a]pyrenol

  12. MEASUREMENTS OF EXPOSURE TO PAH IN WOMEN FROM VALENCIA urine values normalized to creatinine

  13. WHAT IS THE PROBLEM AT LOW CONCENTRATIONS?

  14. WE NEED TO ESTIMATE WHAT ARE THE DELETERIOUS EFFECTS OF EXPOSURE AT LOW AMOUNTS BUT FOR LONG PERIODS ENCOMPASSING ALL LIFE AND ALL GROWTH STAGES (INCLUDING IN UTERO DEVELOPMENT)

  15. Development of neural system in children

  16. Decrease of brain cells with age Small increases of cell losses (0.1 or 0.3% per year) may give rise to clinic emergencies at younger age. Levels of loss of 40% are probable causes of illness

  17. AREA DE ESTUDIO FLIX • Comarca de la Ribera d’Ebre • Ubicada en el curso del río • 4500 habitantes • Industria electroquímica • Agricultura de frutas y hortalizas, almendras, aceite y vino. • FLIX Población rural expuesta a contaminación específica

  18. ACTIVITIES IN THE ELECTROCHEMICAL PLANT Products synthesized Chlorine • Organochlorinated solvents trichloroethylene tetrachloroethylene dichlorometane chloroform... • NaOH, HCl, H2

  19. COMPOUND Flix Barcelona ng/m3 average range average range HCB 35 11-44 0.3 0.25-0.4 PCBs 1 0.1-2 0.7 0.1-1 pp'-DDE 0.2 0.02-0.5 0.1 0.06-0.3 Average 24-hr air concentrations of organochlorine compounds in Flix and the reference community (Barcelona)

  20. 608 Residents from Flix gave biologic samples age: 48.8 years 84.3% lived for more than 20 years in Flix TOTAL 59 51 men 8 women 40 years TOTAL 128 115 men 13 women 62 years TOTAL 421 338 women 83 men 46 years

  21. De l’ordre o inferiors a altres publicadesnferiors o De l’ordre o inferiors a altres publicadesnferiors o In the order or lower than other reported 8 times higher in the population of Flix than in Barcelona 100 times higher than in the USA rural population (Sther-Green y cols, 1988) 23 times higher than in USA general population (Murphy y cols.,1985) 1.4 times higher than Slovakian population (Koçan y cols.1994) b a g

  22. 0.1 - 223 0.3 - 67 0.7 - 38 0.1 - 151 0.4 - 234 2.4 - 953 0.3 - 22 1.1 - 222 5.3 - 1485 b C (ng/ml)

  23. 1.13 mg HCB /dia Estimación de la inhalación de HCB • Criterio OMS (IPCS 1994) adulto 64 Kg --- 22m3 aire 4 horas/día en el exterior • Concentraciones medias Cint = 51 ng/m3 Cext = 26 ng/m3 Referencia: 0.4 10-4 - 2 10-3 mg/día

  24. Descriptionof TSH, total T4, free T4, AST (Aspartate aminotransferase, ALT (Alanine aminotransferase and GGT (Gamma Glutamil Transpeptidase serum levels, by sex and occupational status. Flix, Catalonia • Reference values: • TSH 0.25-5 mIU/ml; Total T4: 4.7-12.4 mg/ml; Free T4: 0.8-2.0 ng/dl; AST: 10-38 UI/l; ALT: 7-33 UI/l; GGT in men: 10-50 UI/l; GGT in women: 5-35 UI/l.

  25. Correlación entre los niveles de HCB y las desviaciones de T4, ALT y GGT

  26. CONCLUSIONES DEL ESTUDIO Los niveles de HCB aumentan: - con el tiempo de residencia, - con el consumo local de pescado. - con la edad de las mujeres - en el grupo de edad media en los hombres Los niveles de HCB en los extrabajadores > 60 años son similares a los no trabajadores. La salud percibida no difiere del resto de Catalunya. Riesgo superior para la totalidad de las enfermedades asociadas al HCB para los que han trabajado alguna vez en la electroquímica. No se ha registrado ningún caso de Porfíria Cutanea Tarda. Seis personas con exceso de porfirinas totales en la orina. Cinco personas con anomalías en el perfil de porfirinas excretadas. Determinación de la ruta metabólica de el HCB: conjugado del glutatión en la orina. Correlación entre el Pentaclorobenzotiol y el HCB en el suero: r2=0.78

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