Case 3. Neuropathology. Please direct any questions regarding this case to Dr. Syed A. Jaffar Kazmi, M.D. History of Present Illness. 68 yr old female presented to ED after having seizure and found to have a new left frontal mass. Hx of Grade IV follicular lymphoma.
Please direct any questions regarding this case to Dr. Syed A. Jaffar Kazmi, M.D.
68 yr old female presented to ED after having seizure and found to have a new left frontal mass.
Hx of Grade IV follicular lymphoma.
MRI shows a left frontal lobe non-enhancing tumor with associated edema and small focus of calcification.
Patient underwent surgery for resection of tumor.
Chicken wire vasculature
Perinuclear halos (fried egg)
Round nuclei and uniform cell density
Nuclei have delicate chromatin, and small nucleoli
Low proliferation index
DiagnosisOligodendrogliomaWHO Grade II
ODG accounts for 10%-15% of all gliomas
Mainly affecting adults
Commonly presented by seizures
Cerebral hemispheres are most common site
MRI: T2 – bright with variable mass effect w or w/o calcification
Perinuclear halos, Minigemistocyte, Microcysts, Calcification,
Prominent vasculature (chicken wire), Secondary structure of
Scher (Perineuronal Satellitosis, Perivascular & Subpial
Uniform cell density with round nuclei with delicate chromatin,
and small nucleoli
Few mitoses, no necrosis or vascular endothelial proliferation
Oligodendroglioma, WHO Grade II
University of Nebraska Medical Center