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Case 3. Neuropathology. Please direct any questions regarding this case to Dr. Syed A. Jaffar Kazmi, M.D. History of Present Illness. 68 yr old female presented to ED after having seizure and found to have a new left frontal mass. Hx of Grade IV follicular lymphoma.

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Case 3

Case 3

Neuropathology

Please direct any questions regarding this case to Dr. Syed A. Jaffar Kazmi, M.D.


History of present illness

University of Nebraska Medical Center

History of Present Illness

68 yr old female presented to ED after having seizure and found to have a new left frontal mass.

Hx of Grade IV follicular lymphoma.

MRI shows a left frontal lobe non-enhancing tumor with associated edema and small focus of calcification.

Patient underwent surgery for resection of tumor.


Histology

University of Nebraska Medical Center

Histology

Perineuronal Satellitosis

Microcysts

Microcalcifications

Chicken wire vasculature

Perinuclear halos (fried egg)

Round nuclei and uniform cell density

Nuclei have delicate chromatin, and small nucleoli

Low proliferation index


Oligodendroglioma who grade ii

University of Nebraska Medical Center

Diagnosis

OligodendrogliomaWHO Grade II


Oligodendroglioma who grade ii1

University of Nebraska Medical Center

Oligodendroglioma, WHO Grade II

ODG accounts for 10%-15% of all gliomas

Mainly affecting adults

Commonly presented by seizures

Cerebral hemispheres are most common site

Radiology

MRI: T2 – bright with variable mass effect w or w/o calcification

Histology

Perinuclear halos, Minigemistocyte, Microcysts, Calcification,

Prominent vasculature (chicken wire), Secondary structure of

Scher (Perineuronal Satellitosis, Perivascular & Subpial

accumulation)

Uniform cell density with round nuclei with delicate chromatin,

and small nucleoli

Few mitoses, no necrosis or vascular endothelial proliferation


University of Nebraska Medical Center

Oligodendroglioma, WHO Grade II

  • Mol

  • 1p36 and 19q13 co-deletions, IDH1 mutation

  • Treatment

  • Surgical resection with observation, radiation,

  • and chemotherapy, depending upon clinical

  • status


University of Nebraska Medical Center

University of Nebraska Medical Center


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