Hemtology. Lecture 10. Definition. the study of blood, the blood-forming organs, and blood diseases. Hematology includes Etiology Diagnosis Treatment Prognosis Prevention of blood diseases that affect the production of blood Mechanism of coagulation.
unknown origin (PUO),
An SOP needs to include:
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hormones, enzymes, products of digestion, and
waste products for excretion)
Early development of B lymphocytes
takes place in the bone marrow and
lymphoid tissues, and development of T lymphocytes in the thymus.
proliferation and differentiation of progenitor cells, and the maturation and functioning of mature cells.
Adult type hemoglobin contains 4 polypeptide chains.
the oxygen carrying part of the haemoglobin molecule.
synthesis of alpha (α) chains.
synthesis of beta (β) chains.
chains leads to:
of red cell precursors in the bone marrow (ineffective erythropoiesis) and red cell destruction by the spleen.
valinereplaces glutamic acid in the beta globin chain
glutamicacid is replaced by lysine in the beta globin chain