1 / 14

Role of Rho-A in Glaucoma

Role of Rho-A in Glaucoma. Jasleen Kaur Narmada Jayasankar Vijetha Vemulapalli. Outline. Open angle Glaucoma RhoA pathway and hypothesis CATPA. Open Angle Glaucoma. It can be defined as damage to the Optic nerve due to Increase in Intra ocular pressure (IOP). Anatomy of the angle.

meghan
Download Presentation

Role of Rho-A in Glaucoma

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Role of Rho-A in Glaucoma Jasleen Kaur Narmada Jayasankar Vijetha Vemulapalli

  2. Outline • Open angle Glaucoma • RhoA pathway and hypothesis • CATPA

  3. Open Angle Glaucoma It can be defined as damage to the Optic nerve due to Increase in Intra ocular pressure (IOP)

  4. Anatomy of the angle

  5. Trabecular meshwork Cornea Retina Shields textbook of glaucoma-2005

  6. Cell cytoskeleton Green: actin Red: mitochondria Blue: nucleus

  7. TM Cell Contractility • Aqueous humor regulation is done by TM cell contractility and re-alignment of pores. • There are two pathways that regulate TM contractility. • Ca dependent pathways • And the Ca independent pathway. • Rho-a protein is involved in the Ca independent pathway.

  8. General Function of Rho-A • Involved in the maintenance of tight junctions. • Tight junctions are found in epithelial cells and all cells where there is a separation or demarcation into different regions. • If the Rho-A pathway does not function properly in the eye, it causes Glaucoma.

  9. pMLC Ca independent pathway MLC Relaxation Contraction Inactive MLCP Active MLCP PP1Cd PP1Cd M20 M20 MYPT1 MYPT1 Plasma membrane P GAP RhoA-GDP RhoA-GTP Rhokinase GEF RhoA-GDP GTP GDP GDI

  10. CATPA

  11. CATPA

  12. Point Mutations

  13. Point Mutations

  14. References • 1. http://biology.kenyon.edu/BMB/Chime2/ 2002/rhoA/FRAMES/captxt.htm • 2. http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=165390 • 3. PDB, CATH, SCOP • 4. http://ajpcell.physiology.org/cgi/content/full/275/3/C798 • 5.http: //www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1220893 • 6. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=14815 • 7. http://147.52.72.117/ijmm/2002/volume9/number6/563-570.pdf • 8. http://apodaca2.dept-med.pitt.edu/PDFs/Rajasesekeran-TJs.pdf • 9. www.ucl.ac.uk/ioo/research/greenwood.htm

More Related