Pulse analysis stroke volume vascular stiffening and cardiovascular disease
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Pulse analysis: stroke volume, vascular stiffening and cardiovascular disease. Tom Archer, MD, MBA UCSD Anesthesia. Pulse analysis is an ancient practice, now making a comeback. http://www.itmonline.org/image/pulse2.jpg. Pablo Picasso, “Science and Charity”, 1897.

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Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Pulse analysis: stroke volume, vascular stiffening and cardiovascular disease

Tom Archer, MD, MBA

UCSD Anesthesia


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Pulse analysis is an ancient practice, now making a comeback.

http://www.itmonline.org/image/pulse2.jpg


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Pablo Picasso, “Science and Charity”, 1897


Traditional pulse analysis subjective and hard to quantify

Traditional pulse “analysis”: subjective and hard to quantify

  • “Waterhammer pulse”-- AI

  • “Slow upstroke”-- AS

  • “Pulsus paradoxus”– cardiac tamponade

  • Is this silly and obsolete stuff?


Pulse analysis was serious business in the 19 th century

Pulse analysis was serious business in the 19th century

  • Sphygmographs in common use.

  • Insurance companies relied on their results.


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Etienne-Jules Marey (1830-1904) invented the sphygmograph to record the arterial pulse on smoked paper. It was used by Engelmann, Mackenzie and Wenckebach.

Sphygmograph 1876

http://www.mamweb.org/modules.php?name=Content&pa=showpage&pid=32000


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Life insurance examination manual from 1891 discussed pulse analysis by sphygmography.


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Tom Archer, 58 y.o., good general health. Takes Crestor for high cholesterol.

Radial and predicted ascending aortic pressure waveform when subject is cold.


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Scipione Riva-Rocci introduced the mercury sphygmo-manometer in 1896.

Measured systolic BP only.


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Harvey Cushing used it.

Korotkoff introduced auscultation for diastolic pressure in 1905.

history.library.ucsf.edu/.../chapter2_03.html


In the 20th century riva rocci and korotkoff s sphygmomanometer eclipsed pulse analysis

In the 20th century, Riva-Rocci and Korotkoff’s sphygmomanometer eclipsed pulse analysis

  • Two simple numbers: systolic / diastolic.

  • Easy to use.

  • Pulse analysis fell into disuse.

  • 20th century saw tremendous gains from simple sphygmomanometry: dangers of high BP.


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

High diastolic blood pressure is associated with increased risk of coronary disease.

Increased diastolic BP is associated with CAD– multiple large studies.

K Hirata (Circ J 2006; 70: 1231–1239)


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

High systolic pressure and pulse pressure are also associated with coronary disease.

For any given systolic pressure, cardiac risk increases with decreasing diastolic BP!

Both increased brachial SBP and increased brachial pulse pressure are associated with increased coronary disease.

K Hirata (Circ J 2006; 70: 1231–1239)


But simple sphygmomanometry ignores valuable information within the pulse trace

But simple sphygmomanometry ignores valuable information within the pulse trace.

  • Extra information can be extracted from the pulse using transducers and computers.

  • Pulse analysis is becoming reproducible and objective.

  • Pulse analysis is JUST SOFTWARE analyzing the BP signal.


Pulse analysis gives two types of information

Pulse analysis gives two types of information

  • “Central blood pressure”

    • Ascending aortic blood pressure from radial waveform.

    • Specifically, we get “Augmentation Index” (AIx)– a measure of extra heart work.

  • Stroke volume (CO, SVR)


Central blood pressure cbp

Central blood pressure (CBP)

  • Systolic pressure in the ascending aorta is NOT the same as brachial or radial systolic BP.

  • Diastolic and mean pressures are very similar at radial / brachial and central sites.


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

LV “sees” the SBP in the ascending aorta.

With normal aortic valve, LV wall tension depends on pressure in ascending aorta

(and diameter of LV chamber).

health.yahoo.com/topic/heart/overview/article...


Heart sees central aortic systolic pressure not brachial artery pressure

Heart “sees” central aortic systolic pressure, not brachial artery pressure.

  • Obviously, it’s hard to measure ascending aorta pressure directly.

  • Ascending aortic (“central”) BP can be extrapolated from the radial pulse.


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

SphygmoCor system for measuring central blood pressures


What creates central bp

What creates central BP?

  • Stroke volume

  • Aortic stiffness (compliance / Windkessel)

  • Systemic vascular resistance (“runoff”)

  • Reflected pressure wave


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

What creates central BP?

#2 Stiffness of aorta (“windkessel”)

AIR

BLOOD

heart

Central BP

#1 SV

veins

arteries

#4 Wave reflection–

timing and amount

#3 Systemic vascular resistance (resistance arterioles)

Muscular arteries


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Augmentation index– extra cardiac work due to wave reflection

AIx =

Augmentation Pressure /

Pulse Pressure

Kozo Hirata, MD; Masanobu Kawakami, MD; Michael F O’Rourke, MD, DSc*Circ J 2006; 70: 1231–1239


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Augmentation index is a deadly backdraft of pressure which exhausts the heart over time.


Run animation

Run animation

  • Wave reflection animation can be found at:

  • http://atcormedical.com/wave_reflection.html


Augmentation index aix

Augmentation Index (AIx)

  • AIx = unnecessary heart work.

  • High AIx leads to LVH and cardiomyopathy.

  • Lower AIx is better.

  • Treatments that lower AIx help the patient.


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Hypertensive patients treated to identical brachial BP

endpoints with

amlodipine

and

atenolol

show lower

central BPs and AIx

with amlodipine

CAFE / ASCOT study, M. O’Rourke (Circulation. 2006;113:1213-1225.)


A given brachial bp measurement does not say what central bp the heart is actually generating

A given brachial BP measurement does not say what central BP the heart is actually generating.

Antihypertensive drugs may exert

their beneficial effects via effects on

central blood pressure.

These effects may not be appreciated

by just measuring brachial BP


Central bps ascot cafe study

Central BPs– ASCOT / CAFE study

  • Lower central BPs are associated with better CV outcomes.

  • Amlodipine achieved lower central BPs and had better CV outcomes than atenolol, despite achieving the same brachial artery BPs.

CAFE / ASCOT study, M. O’Rourke (Circulation. 2006;113:1213-1225.)


When is aix high chronically

When is AIx high-- chronically?

  • Normal aging

  • Obesity

  • Atherosclerosis

  • Diabetes

  • Pre-eclampsia

  • Inflammatory arthritis

  • Renal failure


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

As healthy individuals age, reflected wave arrives at ascending aorta earlier and increases augmentation index and central pulse pressure.

WW Nichols Curr Opin Cardiol 2002, 17:543–551


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Tom Archer, 58 yo, after work, seated comfortably. Aix = 11%.


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

67 y.o. obese female-- AIx 24%


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

77 y.o. man. Never smoked.

Aix = 29%.


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

42 y.o. obese female, smoker.

Aix = 36%


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

77 yo male, ESRD, AV fistula, CAD, HBP

Takes atenolol, lisinopril, terazosin, finasteride. Aix = 39%


When is aix high acutely

When is Aix high– acutely?

  • Arterial compression in legs (squatting)

  • Cold body temperature.

  • Nicotine ingestion


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Tom Archer, 58 y.o., while squatting.

Aix = 21%


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Tom Archer, seated, very cold from being outside in winter.

Aix = 27%


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Exposure of healthy young adults to cold air for 30 min increases augmentation index.

David G. Edwards,1 Amie L. Gauthier,2 Melissa A. Hayman,2 Jesse T. Lang,2 and Robert W. Kenefick2J Appl Physiol 100: 1210–1214, 2006.


Does cold weather increase mi rate due to increased aix

Does cold weather increase MI rate due to increased AIx?


Perioperative hypothermia increases cardiac event rate

Perioperative hypothermia increases cardiac event rate.

Is this due to increased AIx with hypothermia?


What makes aix go down chronically

What makes AIx go down-- chronically?

  • Exercise

  • Weight loss

  • Red wine

  • Statins

  • Control of blood pressure (ACEI and CCB)

  • NTG


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Ted A, 30 yo, at rest, seated. Subject runs marathons. Aix = -14%.


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

64 yo obese male. HBP on lisinopril. Moderate ETOH consumption.

Aix = 14%.


What makes aix go down acutely

What makes Aix go down-- acutely?

  • Exercise

  • Red wine

  • Lowering blood pressure

  • NTG


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Tom Archer, 58 yo, after exercise and wine.

AIx = 1%


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

NTG reduces wave reflection and AIx by dilating muscular arteries.

Is this its primary mechanism of action?

S. C. MILLASSEAU, R. P. KELLY, J. M. RITTER and P. J. CHOWIENCZYK

Clinical Science (2002) 103, 371–377


What determines augmentation index

What determines augmentation index?

  • Timing of wave reflection– pulse wave velocity. Faster wave return is bad.

  • Amount of wave reflection– muscular artery tone.

    • NTG reduces muscular artery tone and wave reflection

    • Does NTG work by decreasing AIx? Yes, at least in part.


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

PWV (aortic stiffness)

increases with age.

AR Khoshdel Journal of Hypertension 2006, 24:1231–1237


Aix increases in inflammatory states

Obesity

OSA

Hyperglycemia

Sepsis

Pre-eclampsia

Lupus

Cocaine

Hypercholesterolemia

AIx increases in “inflammatory” states:


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

MT, 22 yo, healthy, in labor, epidural in place and she is comfortable.

Aix = -1%.


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

JM, 21 yo, in labor, recent onset lupus, on prednisone and plaquenil

Aix = 6%


Statins and ace inhibitors can lower central bps and aix

Statins and ACE inhibitors can lower central BPs and AIx


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

6 months Rx with atorvastatin decreased central aortic pulse pressure and augmentation index.

WW Nichols Curr Opin Cardiol 2002, 17:543–551


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Four months Rx with lisinopril decreased central aortic pulse pressure and augmentation index.

WW Nichols Curr Opin Cardiol 2002, 17:543–551


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

DO, 56 yo female, hypertensive, diabetic May 31, 2007. Aix = 41%


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

DO, 56 yo female, hypertensive, diabetic January 3, 2008. After weight loss and 3 weeks Lipitor. AIx = 26%


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

ACE inhibitors and aldosterone antagonists can reverse LV hypertrophy—is this due to decreased AIx and strain on the heart?


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

ACE inhibitors and aldosterone antagonists reverse LV hypertrophy– via central BP effects?.

Adams KF, Am J Health-Syst Pharm—Vol 61 May 1, 2004 Suppl 2


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Radial Pulse Analysis II:Pulse analysis to determine stroke volume and cardiac output from the arterial pressure trace.


Pulse contour analysis

Pulse contour analysis

  • We’ll skip the math and validation studies.

  • Intuitively– the bigger the waveform and the longer it lasts, the bigger the stroke volume.

  • Calibration (e.g. with lithium dilution) vs. age / weight / height algorithm to predict probable aortic compliance and then follow trends.


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Big stroke volume

P

R

E

S

S

U

R

E

Small stroke volume


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

PiCCO system of pulse contour analysis

Aortic compliance

(low compliance and stiff aorta means high pulse pressure)

Systemic vascular resistance

(low resistance means rapid fall in diastolic pressure)

Godje O Crit Care Med 2002 Vol. 30, No. 1


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Stroke volume from arterial pressure trace--- PulseCO from LiDCO Ltd. (UK)


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Stroke volume from arterial pressure trace--- Edwards Life Sciences, Irvine California


Stroke volume estimation by pulse contour analysis

Stroke Volume Estimation by Pulse Contour Analysis

  • Complicated

  • Lots of physics and math

  • Computerized

  • Real time

  • Needs a good waveform

  • Has limitations, but it usually works


Stroke volume estimation by pulse contour analysis1

Stroke volume estimation by pulse contour analysis

  • Just software for analyzing pulse contour.

  • No additional patient risk or invasion over that of arterial line alone.


Pulseco hemodynamic examples

PulseCO:Hemodynamic examples


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Dramatic drop in SV, CO and BP with small dose of propofol (40 mg) after loading with fentanyl, lidocaine and esmolol.

CO

SVR

BP

SV HR


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Continuous spinal in morbidly obese parturient at C/S causes fall in SVR, rise in CO. Phenylephrine increases SVR and decreases CO.


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

GA induction with etomidate and sux associated with extreme hypertension in patient with pre-eclampsia and lupus. Hypertension due to both inc CO and inc SVR.


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Repeat CS. Epidural anesthesia. Delivery with inc in HR and CO, oxytocin bolus with decrease SVR and BP, increase in CO and SV.


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Septic woman for CS. SVR does not rise with intubation (A) and incision (B).

Nominal cardiac output L/min

20

10

0

Nominal systemic vascular resistance dyn.sec.cm-5

1000

500

0

Blood pressure mm Hg

200

100

0

Heart rate beats/min and nominal stroke volume mL

150

100

50

0

SV

0A 5 10 B 15 C/D 20

minutes


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Tourniquet inflation on leg increases SVR and MAP and decreases CO. Deflation reverses these changes.


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Phenylephrine and vasopressin both increase SVR and decrease CO (in this patient).


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Repeat CS, CSE. Severe pre-eclampsia. Multiple nicardipine boluses cause decreases in SVR and MAP, increases in SV and CO.


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

CS patient with severe pre-eclampsia superimposed on CRF: Antihypertensive therapy with labetalol 25 mg and hydralazine 5 mg (A) and nicardipine 250 µ total (B). Behind almost “stable” BP is drop in SVR, rise in CO.

Nominal cardiac output L/min

8

4

0

Nominal systemic vascular resistance dyn.sec.cm-5

3000

2000

1000

0

Blood pressure mm Hg

200

100

0

Heart rate beats/min and nominal stroke volume mL

150

100

50

0

0 10 20 30 40

A minutes B V


Pulse analysis stroke volume vascular stiffening and cardiovascular disease

Methylene blue x 2 and indigo carmine x 1 scavenge NO and increase SVR. Cystoscopy after C-hysterectomy, GA, placenta percreta.


In conclusion

In conclusion

  • Radial pulse wave analysis can give us two types of information:

    • Central BPs and augmentation index, a measure of unnecessary heart work

    • Stroke volume (and CO and SVR)


In conclusion1

In conclusion

  • Pulse wave analysis has two distinct techniques:

    • Radial pulse tonometry (CBP and AIx)

      • AtCor Medical (SphygmoCor)

    • Pulse contour analysis (SV, CO and SVR)

      • LiDCO

      • Vigileo (Edwards)

      • PiCCO

      • Others


In conclusion2

In conclusion

  • Radial pulse tonometry gives us central blood pressures and a measure of unnecessary heart work during systole– augmentation index (AIx).

  • Central BPs and AIx may be the “smoking gun” for CV damage.


In conclusion3

In conclusion

  • Helpful therapeutic interventions such as ACE inhibitors, statins, calcium channel blockers and NTG may exert some of their therapeutic effects via their effects on central BP and AIx.

  • Hence, measurement of these parameters may become part of the routine Dx and Rx of CV disorders.


In conclusion4

In conclusion

  • Measurement of CBP and AIx may become useful in acute CV care. This is speculative at this point.

  • It behooves us to put this technology on our “radar screen”.


In conclusion5

In conclusion

  • Pulse contour analysis: several companies are working hard in this field.

  • I am most familiar with LiDCO, but Edwards is pushing hard with Vigileo.


In conclusion6

In conclusion

  • Pulse contour analysis to estimate stroke volume, CO and SVR works well enough to be clinically useful.

  • I find it fascinating and a great teaching and learning tool.

  • Even if the numerical estimates are incorrect, the trends are correct.

  • Both LiDCO and Edwards have “calibration-free” products.


Questions for the future

Questions for the future

  • Will radial pulse tonometry (and AIx) become a routine office evaluation of patients at risk for CV disease?

  • Will it provide an “early warning system” for the development of CV disease?

  • Will it guide drug therapy of CV disease?


Questions for the future1

Questions for the future

  • Will measurement and pharmacological manipulation of AIx in critical care improve patient outcomes?


Questions for the future2

Questions for the future

  • Will pulse contour analysis for CO and SVR be incorporated into standard arterial line monitoring as a routine?


The end questions

The EndQuestions?


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