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Chemical Mixture Method (CMM) Health Code Number (HCN) Update. Xiao-Ying Yu, PNNL Rocky Petrocchi, ATL. CMM Rev 25—Status. CMM Workbook “Rev 25” published in October 2009 CMM Rev 25 contains the PAC/TEEL data published in PAC Rev 25 CMM and PAC data sets are “consistent” .

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Chemical Mixture Method (CMM)Health Code Number (HCN)Update

Xiao-Ying Yu, PNNL

Rocky Petrocchi, ATL

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CMM Rev 25—Status

  • CMM Workbook “Rev 25” published in October 2009

  • CMM Rev 25 contains the PAC/TEEL data published in PAC Rev 25

  • CMM and PAC data sets are “consistent”

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CMM Rev 26 — Status

  • CMM Workbook“Rev 26”

    • Will include HCNs for 6 new chemicals

    • Will include updated HCNs for 1040 chemicals

    • Will include new/revised PAC/TEEL data

    • Will be posted on SCAPA website shortly after PAC Rev 26 is published

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HCN Update Status

  • Update HCNs for “Older” Chemicals

    • ~ 2346 chemicals required review and updates

    • The multi-year effort started since June 2009

    • ~1040 (44%) chemicals updated to date

    • 162 (15%) chemicals need QA

    • 28 (18%) chemicals done to date

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2010 HCN Update Project Team

  • New Summer Intern, Hua He (WSU/MS), starts in June 2010

  • Kim Schuette (WSU/graduating senior), starts in June 2010, fully supported by NSF/DOE STAR program

  • Donna Trott (PNNL) will provide training to the interns

  • Xiao-Ying Yu (PNNL) will provide mentorship and supervise their progress

  • Rocky Petrocchi (ATL) will provide technical leadership and manage QA

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2010 HCN Update Goals

  • Update as many of the remainder of chemicals (~1300) as possible by December, 2010

  • Perform detailed QA review of 10% - 15% of updated chemicals

  • Incorporate this round of updates in CMM Rev 27 (May 2011?)

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CMM Research Article

  • Scope

    • Reviews purpose and principle of CMM

    • Presents CMM updates since the publication of Craig et al. in 1999

    • Focuses on advances in HCN development

    • Illustrates CMM real-worldapplication

  • Targeted Journal

    • Journal of Applied Toxicology

  • Status

    • Submitted in April 2010

  • EMI-SIG / SCAPA 2009

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    Surrogate Source Term Article

    • Scope

      • Introduce surrogate source term method as an interim method for real-time application of CMM

    • Candidate Journals

      • Journal of Applied Toxicology

      • Atmospheric Environment

  • Project Status

    • First draft finished in Nov. 2009

    • Revisions being discussed between lead authors John Ciolek and Xiao-Ying Yu

    • Targeted for journal submission by end of FY 2010

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    The CMM Online Wizard

    • Goal: Explore a tool for on-line usage of CMM

    • Features:

      • Breaks free of Excel Workbook constraints

      • Uses an Access database

      • Employs a user-friendly design

      • Accepts any number of chemicals in a mixture

      • Provides same output tables as the Excel workbook

      • Analogous to the on-line PAC data base

    • Currently available on the PNNL server for testing:

    • Check it out later today -- we want feedback!

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    The CMM Wizard Illustration

    Front page, choose how to enter your chemicals

    Let’s try the first option.

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    Select chemicals by CASRN, chemical name or SAX number

    hydrogen chloride


    Hit add to select

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    Results: Summary of HIs

    Choose HIs by Mode or by Target Organ

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    Some CMM Users & Uses

    • Hanford: Tank Farm Emissions Analysis

    • SRS: EPHA, Safety Analysis, Waste Analysis

    • Sandia (NM): ER Modeling

    • INL: EPHA Analysis

    • Y-12: EPHA Analysis

    • Others: LLNL, LANL, Jefferson Lab (DOE), NOAA Hazmat, Univ. of Florida

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    Chemical Mixture Method (CMM)

    Health Code Number (HCN)



    • Xiao-Ying Yu, PNNL

    • Rocky Petrocchi, ATL