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Receptors. Anatomic Locations for Nausea. Anti-Emetic Medications. 5-HT 3. D 2. M 1 , H 1. GABA. Dimenhydrinate. Receptor types. Receptor types. Receptor types. Scopolamine. Vestibulum. Promethazine. CNS. Prochlorperazine. Area Postrema. Metoclopramide. Click an anatomic location.

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slide1

Receptors

Anatomic Locations for Nausea

Anti-Emetic Medications

5-HT3

D2

M1, H1

GABA

Dimenhydrinate

Receptor types

Receptor types

Receptor types

Scopolamine

Vestibulum

Promethazine

CNS

Prochlorperazine

Area Postrema

Metoclopramide

Click an anatomic location

GI Tract

Ondansetron

Benzodiazepines

Corticosteroids

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X

slide2

Receptors

Anatomic Locations for Nausea

Anti-Emetic Medications

M1, H1

Dimenhydrinate

Scopolamine

Vestibulum

Promethazine

Dimenhydrinate (Dramamine) is available OTC. The three medications are anticholinergic.

X

slide3

Receptors

Anatomic Locations for Nausea

Anti-Emetic Medications

5-HT3

D2

M1, H1

GABA

Dimenhydrinate

Scopolamine

Promethazine

CNS

Prochlorperazine

Metoclopramide

Ondansetron

↑ intracranial pressure may require corticosteroid tx. Benzodiazepines may be used for psychiatric causes.

Benzodiazepines

Corticosteroids

X

slide4

Receptors

Anatomic Locations for Nausea

Anti-Emetic Medications

5-HT3

D2

Prochlorperazine

Area Postrema

Metoclopramide

Ondansetron

Opioid receptors are present in the area postrema, which is located at the base of the 4th ventricle

X

slide5

Receptors

Anatomic Locations for Nausea

Anti-Emetic Medications

D2

Promethazine

Prochlorperazine

Metoclopramide

GI Tract

Metoclopramide (Reglan) is prokinetic). Promethazine (Phenergan) has more M1/H1-receptor action than D2. Rule out impactions.

X

anti emetics

Anti-Emetics

From Juan Palacios, MD

Created by Dan Cushman

2010

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