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Antibody-Based Therapeutics for Treating Alzheimer’s and Parkinson’s Diseases

Antibody-Based Therapeutics for Treating Alzheimer’s and Parkinson’s Diseases. Taylor Brownlee Dr. Michael Sierks Chemical Engineering 2012 Arizona/NASA Space Grant Symposium University of Arizona. April 21, 2012. 2. What Causes Alzheimer’s and Parkinson’s D iseases?.

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Antibody-Based Therapeutics for Treating Alzheimer’s and Parkinson’s Diseases

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  1. Antibody-Based Therapeuticsfor Treating Alzheimer’s and Parkinson’s Diseases Taylor Brownlee Dr. Michael Sierks Chemical Engineering 2012 Arizona/NASA Space Grant Symposium University of Arizona April 21, 2012

  2. 2 What Causes Alzheimer’s and Parkinson’s Diseases? • Alzheimer’s disease (AD) and Parkinson’s disease (PD) are devastating neurodegenerative diseases • Plaques and tangles (AD) or Lewy bodies (PD) • Accumulate in different areas of the brain • Block nerve cell communication and cause cell death • Presence of plaques and tangles or Lewy bodies is not a definitive diagnosis for AD or PD http://www.ahaf.org/alzheimers/

  3. Research Objectives • Process of protein misfolding and accumulation causes disease • β-amyloid and α-synuclein are two biomarkers (proteins) linked to AD and PD • Oligomeric forms of β-amyloid and α-synuclein are the key toxic species • Identify antibodies to detect β-amyloid and α-synuclein • Can be used for therapeutics and diagnostics

  4. Sandwich ELISA

  5. Results for PD Antibody

  6. Conclusions • Process of protein misfolding and accumulation causes Alzheimer’s and Parkinson’s diseases • Antibodies detect toxic biomarker species that cause AD and PD • Sandwich ELISA detects the biomarker concentration • 1E-07 M13 bacteriophage concentration yielded the largest biomarker signal • Further study must be done to perfect ELISA protocol

  7. Thank you!Questions?

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