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Thomas Wakley ...all is darkness and confusion, vague theory, and a vain speculation. Is it a fungus, an insect, a miasm, an electrical disturbance, a deficiency of ozone, a morbid off-scouring from the intestinal canal? We know nothing; we are at sea in a whirlpool of conjecture.
Friedrich Henle The material of contagions is not only an organic but a living one and is indeed endowed with a life of its own, which is, in relation to the diseased body, a parasitic organism.
Koch's postulates • the pathogen must be found in every individual who has the disease. • the pathogen must be isolated from a diseased individual and grown separately in a pure culture. • the disease must be induced in an experimental animal by transferring the pathogen from the pure culture. • the same pathogen must be isolated from the experimental animal after it has contracted the disease.